# Acmg Variant Classifier

> ACMG/AMP variant classification skill for systematic pathogenicity assessment

- Skill: `a5c-ai/acmg-variant-classifier` (Agent Skill)
- Install (CLI): `npx skillmds@latest add a5c-ai/acmg-variant-classifier`
- Raw SKILL.md: https://api.skillmd.com/api/skills/a5c-ai/acmg-variant-classifier/raw
- Safety review: pending (external: skill-scanner PASS, skillspector PASS)
- Works with: Claude Code, Claude.ai, OpenAI Codex
- Category: Coding & Dev Tools
- Author: a5c-ai (https://skillmd.com/u/a5c-ai)
- Updated: 2026-09-09
- Page: https://skillmd.com/skills/a5c-ai/acmg-variant-classifier

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# ACMG Variant Classifier Skill

## Purpose
Enable ACMG/AMP variant classification for systematic pathogenicity assessment following clinical guidelines.

## Capabilities
- Automated evidence criteria application
- Population frequency filtering
- In silico prediction integration
- Literature evidence curation
- Inheritance pattern analysis
- Classification report generation

## Usage Guidelines
- Apply ACMG criteria systematically
- Document evidence for each criterion
- Consider inheritance patterns in assessment
- Review literature for supporting evidence
- Generate clear classification reports
- Track classification changes over time

## Dependencies
- InterVar
- VarSome API
- ClinVar

## Process Integration
- Clinical Variant Interpretation (clinical-variant-interpretation)
- Rare Disease Diagnostic Pipeline (rare-disease-diagnostics)
- Newborn Screening Genomics (newborn-screening-genomics)