# Blast Sequence Search

> BLAST skill for sequence similarity searching, homology detection, and database querying

- Skill: `a5c-ai/blast-sequence-search` (Agent Skill)
- Install (CLI): `npx skillmds@latest add a5c-ai/blast-sequence-search`
- Raw SKILL.md: https://api.skillmd.com/api/skills/a5c-ai/blast-sequence-search/raw
- Safety review: pending (external: skill-scanner PASS, skillspector PASS)
- Works with: Claude Code, Claude.ai, OpenAI Codex
- Category: Coding & Dev Tools
- Author: a5c-ai (https://skillmd.com/u/a5c-ai)
- Updated: 2026-09-09
- Page: https://skillmd.com/skills/a5c-ai/blast-sequence-search

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# BLAST Sequence Search Skill

## Purpose
Provide BLAST capabilities for sequence similarity searching, homology detection, and database querying across nucleotide and protein sequences.

## Capabilities
- BLASTn/BLASTp/BLASTx execution
- Custom database creation and management
- E-value and alignment filtering
- Output parsing and result annotation
- Batch query processing
- Remote NCBI database queries

## Usage Guidelines
- Select appropriate BLAST program for query/database type
- Set E-value thresholds based on search sensitivity needs
- Create custom databases for project-specific searches
- Parse and filter results for downstream analysis
- Consider computational resources for large searches
- Document database versions for reproducibility

## Dependencies
- NCBI BLAST+
- DIAMOND
- MMseqs2

## Process Integration
- Whole Genome Sequencing Pipeline (wgs-analysis-pipeline)
- Protein Structure Prediction (protein-structure-prediction)
- Shotgun Metagenomics Pipeline (shotgun-metagenomics)