# Hpo Phenotype Matcher

> Human Phenotype Ontology skill for phenotype-driven gene prioritization

- Skill: `a5c-ai/hpo-phenotype-matcher` (Agent Skill)
- Install (CLI): `npx skillmds@latest add a5c-ai/hpo-phenotype-matcher`
- Raw SKILL.md: https://api.skillmd.com/api/skills/a5c-ai/hpo-phenotype-matcher/raw
- Safety review: pending (external: skill-scanner PASS, skillspector PASS)
- Works with: Claude Code, Claude.ai, OpenAI Codex
- Category: Coding & Dev Tools
- Author: a5c-ai (https://skillmd.com/u/a5c-ai)
- Updated: 2026-09-09
- Page: https://skillmd.com/skills/a5c-ai/hpo-phenotype-matcher

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# HPO Phenotype Matcher Skill

## Purpose
Provide Human Phenotype Ontology capabilities for phenotype-driven gene prioritization.

## Capabilities
- HPO term matching
- Gene-phenotype association scoring
- Semantic similarity analysis
- Phenotype-variant correlation
- Exomiser integration
- Prioritization reporting

## Usage Guidelines
- Map clinical phenotypes to HPO terms
- Calculate gene-phenotype associations
- Use semantic similarity for ranking
- Integrate with variant prioritization
- Generate prioritization reports
- Document phenotype encoding

## Dependencies
- HPO
- Exomiser
- Phen2Gene

## Process Integration
- Rare Disease Diagnostic Pipeline (rare-disease-diagnostics)
- Clinical Variant Interpretation (clinical-variant-interpretation)