# Enda Preliminary Cortisol Acth Test

> Suggests using morning cortisol ≤140 nmol/L (5 µg/dL) in combination with ACTH as a preliminary test suggestive of primary adrenal insufficiency when a corticotropin stimulation test is not feasible. Use when patients present with indicative symptoms such as hypotension, hyponatremia, hyperkalemia, or fatigue and corticotropin stimulation testing cannot be performed.

- Skill: `dromlakhani/enda-preliminary-cortisol-acth-test` (Agent Skill)
- Install (CLI): `npx skillmds@latest add dromlakhani/enda-preliminary-cortisol-acth-test`
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- Author: dromlakhani (https://skillmd.com/u/dromlakhani)
- Updated: 2026-09-08
- Page: https://skillmd.com/skills/dromlakhani/enda-preliminary-cortisol-acth-test

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# Use Morning Cortisol and ACTH as Preliminary Test for PAI

## STEP 1 — Gather Information
Collect morning plasma cortisol (drawn 6–10 AM) and plasma ACTH; assess clinical signs suggestive of PAI (e.g., hypotension, hyponatremia, hyperkalemia, fatigue, weight loss, hyperpigmentation). If corticotropin stimulation test is not feasible, proceed.

## STEP 2 — Rule In / Rule Out
Apply cutoff: morning cortisol ≤140 nmol/L (5 µg/dL) AND ACTH >2× upper limit of reference range (or elevated per assay). If both criteria met, rule in possible PAI; if cortisol >140 nmol/L or ACTH not elevated, rule out PAI for now and consider alternative diagnoses.

## STEP 3 — Classify or Stratify
If ruled in, classify as preliminary suggestive of primary adrenal insufficiency; note that confirmatory corticotropin stimulation test should be performed when feasible. If ruled out, consider other causes of adrenal insufficiency or non-adrenal etiologies.

## STEP 4 — Decide
If preliminary test suggestive, initiate stress-dose glucocorticoid therapy if patient is acutely ill or adrenal crisis suspected, and arrange for corticotropin stimulation test as soon as possible; otherwise, schedule confirmatory test and educate patient on adrenal crisis prevention.

## Clinical Guardrails / Mimics / Pitfalls
Do not rely solely on this preliminary test for definitive diagnosis; avoid using in community-based screening; beware of estrogen-containing medications that raise CBG and cortisol, which may falsely normalize cortisol; remember that ACTH assays vary and a single elevated ACTH may be spurious; do not delay definitive testing when corticotropin stimulation becomes available.

## Concrete Clinical Example
A 58‑year‑old woman presents with fatigue, postural hypotension, and serum sodium 128 mmol/L. Morning cortisol is 110 nmol/L (4 µg/dL) and ACTH is 85 pmol/L (reference <45 pmol/L). Corticotropin stimulation test is delayed due to equipment unavailability. Preliminary test meets criteria (cortisol ≤140 nmol/L, ACTH >2× ULN), so she is started on hydrocortisone 15 mg morning, 10 mg afternoon and referred for prompt stim test.

**Source:** Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline, Endocrine Society, 2016, https://doi.org/10.1210/jc.2015-1710

> **TODO:** consider adding scripts/calc.py for the enda-preliminary-cortisol-acth-test calculator