# Biomni Research Agent

> Bio-Research Generalist

- Skill: `fridrichmethod/biomni-research-agent` (Agent Skill)
- Install (CLI): `npx skillmds@latest add fridrichmethod/biomni-research-agent`
- Raw SKILL.md: https://api.skillmd.com/api/skills/fridrichmethod/biomni-research-agent/raw
- Safety review: pending
- Works with: Claude Code, Claude.ai, OpenAI Codex
- Category: AI & ML
- License: MIT
- Author: FridrichMethod (https://skillmd.com/u/fridrichmethod)
- Updated: 2026-09-17
- Page: https://skillmd.com/skills/fridrichmethod/biomni-research-agent

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# Biomni (General Biomedical Agent)

A general-purpose biomedical AI agent capable of executing complex research workflows using over 150 tools and databases.

Biomni is a "General-Purpose" biomedical agent. Unlike specialized skills (e.g., just for folding proteins), Biomni acts as a high-level orchestrator that can break down complex open-ended research questions into solvable sub-tasks using a vast library of tools.

## When to Use This Skill

*   **Complex Questions**: "What are the potential drug targets for Alzheimer's related to mitochondrial dysfunction?"
*   **Multi-Step Research**: Tasks requiring literature search, data retrieval, and analysis in sequence.
*   **Exploratory Analysis**: When the exact path to the answer isn't known and requires "reasoning."

## Core Capabilities

1.  **Tool Use**: Access to 150+ tools, 105 software packages, and 59 databases.
2.  **Hypothesis Generation**: Can formulate scientific hypotheses and plan experiments to test them.
3.  **Plan & Execute**: Breaks down queries into a dependency graph of tasks.
4.  **Database QA**: High accuracy (74.4%) in querying biomedical databases.

## Workflow

1.  **Query Parsing**: The agent analyzes the user's natural language request.
2.  **Tool Selection**: It selects relevant tools (e.g., "Search GWAS Catalog", "Run GO Enrichment", "Fetch Uniprot Data").
3.  **Execution Loop**:
    *   Step 1: Get data.
    *   Step 2: Analyze data.
    *   Step 3: Refine plan based on intermediate results.
4.  **Synthesis**: Combines all findings into a comprehensive answer.

## Example Usage

**User**: "Identify genes associated with Type 2 Diabetes that are also expressed in the pancreas and have approved drugs."

**Agent Action**:
1.  Tool: `OpenTargets` -> Get T2D associated genes.
2.  Tool: `GTEx` -> Filter for high expression in Pancreas.
3.  Tool: `DrugBank` -> Intersect with drug targets.
4.  Result: Returns a list of genes (e.g., *GLP1R*, *DPP4*) and their drugs.

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