# Mutation Generator

> Generate conservative vs aggressive peptide mutation variants given a reference sequence and optional protected/hotspot positions.

- Skill: `lamm-mit/mutation-generator` (Agent Skill, multi-file: 3 files)
- Install (CLI): `npx skillmds@latest add lamm-mit/mutation-generator`
- Raw SKILL.md: https://api.skillmd.com/api/skills/lamm-mit/mutation-generator/raw
- Safety review: pending
- Works with: Claude Code, Claude.ai, OpenAI Codex
- Category: Coding & Dev Tools
- Author: lamm-mit (https://skillmd.com/u/lamm-mit)
- Updated: 2026-09-17
- Page: https://skillmd.com/skills/lamm-mit/mutation-generator

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# Mutation Generator

Creates a small mutation space for a peptide scaffold.

- Conservative: substitutions within broad physicochemical groups
- Aggressive: larger substitutions, multiple mutations

## CLI
```bash
python3 scripts/run.py --sequence AGCKNFFWKTFTSC --strategy conservative --n-variants 8
python3 scripts/run.py --sequence AGCKNFFWKTFTSC --strategy aggressive --max-mutations 3 --n-variants 12
```