Tooluniverse

Tooluniverse from mims-harvard/tooluniverse.

Install

npx skillmds@latest add plugin:mims-harvard/tooluniverse

One command, no setup. In Claude Code it lands as a managed plugin you can enable, disable or remove with /plugin. On any other agent it installs the 181 skills into that agent's own folder.

Or inside Claude Code

In the Plugins tab, add this marketplace:

skillmds/skillmd
/plugin install mims-harvard-tooluniverse@skillmd

Adds the marketplace once; later plugins need the second line only.

Or install by hand

Download the plugin and unzip its skills/ folder into your agent's skills directory. Works with every agent, no CLI needed.

Download plugin Paths per agent

Just the markdown? SKILL.md files only.

This plugin

skills: 181
authors: 1

Published by a registry member. Review its skills before installing.

Skills in this plugin

181

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Tooluniverse Residue Functional Mechanism Interpretation · mims-harvard
Given a set of residues in a protein, explain WHY they are functionally critical by combining structural context (binding interface, ligand pocket, core, secondary structure), UniProt features (active sites, binding sites, PTM sites, disulfides), optional SAE feature evidence, and optional DMS data. Accepts residues from any source: DMS hotspots (top-K by max effect), ClinVar recurrent variants, literature-reported hot regions, evolutionarily conserved positions, or user-curated lists. Returns a per-cluster mechanism call: catalytic / ligand-binding / interface / structural-core / PTM / regulatory / unknown.

1 install