Results for “polygenic-risk-score”

Computes evidence-aware polygenic risk scores from local VCF or WGS files using the just-prs engine and a pinned local MCP server, with honest interpretation and model comparison.

Score and rank options contracts for any ticker using a multi-factor model covering liquidity, IV attractiveness, Greeks balance, and risk/reward. Returns scored option chains with the best contracts highlighted.

Assigns behavioral trust grades (A–F) to MCP servers by running probes for prompt injection, permission overreach, data leaks, and adversarial-input handling, and publishes reproducible onchain attestations.

Computes the R2Score metric using torchmetrics, handling single and multi-output predictions with options for adjusted and variance-weighted scores.

This skill should be used when the user asks about "Polymarket", "prediction markets", "betting odds", "place a bet", "check odds", "market predictions", "what are the odds", "bet on election", "sports betting", or any prediction market operation. Provides guidance on searching markets, placing bets, and managing positions.

Validates the Emotional Attitude Score (EAS) metric by measuring its consistency with human judgment on word-level sentiment polarity, using the AmbGIMT dataset and pairwise score comparisons.

Add account state (P&L, win rate, drawdown) to RL observations + drawdown penalty in rewards. Trigger when: (1) model needs account awareness, (2) training should penalize drawdowns, (3) upgrading obs_dim 5300→5600.

Scales reinforcement learning with PufferLib — high-throughput parallel training (PuffeRL), vectorized environments, and native multi-agent systems achieving 2-10x speedups over standard implementations. Use when scaling RL to millions of steps per second, running vectorized or multi-agent setups, building custom PufferEnv tasks, or integrating game environments (Atari, Procgen, NetHack, PettingZoo). For standard single-agent algorithm implementations (PPO/SAC/DQN) or quick prototyping prefer alterlab-stable-baselines3. Part of the AlterLab Academic Skills suite.