Results for “allele-frequency”

Query gnomAD (Genome Aggregation Database) for population allele frequencies and gene constraint scores (pLI, LOEUF) reflecting loss-of-function intolerance. Use when checking how common a variant is across populations, filtering rare-disease candidate variants, assessing variant pathogenicity, or identifying loss-of-function intolerant genes. Part of the AlterLab Academic Skills suite.

BALD EAGLE v3.0 — XYZ Alpha Hunter (Hardened). Focused on 6 high-liquidity XYZ assets: CL, BRENTOIL, GOLD, SILVER, SP500, XYZ100. Conviction-scaled leverage (5-10x based on score). Wider DSL for macro assets. Maker-only execution. Scanner calls create_position internally. v3.0: focused assets, conviction-scaled leverage, XYZ-tuned DSL, no thesis exit.

Use when filling ancestral alleles into the INFO column of VCF files using ancestral alignment data from 1000 Genomes or similar sources.

Query gnomAD for population allele frequencies, constraint metrics, and loss-of-function intolerance. Use when interpreting variants, filtering common alleles, or prioritizing genes in rare disease workflows.

Analyze AMS waveform data using Mixed-Signal Blockset utilities: phase noise measurement, clock jitter, anti-aliased resampling, timing measurements, lock time, INL/DNL, ADC/DAC calibration, HSpice import. Use when analyzing time-domain voltage from PLL/VCO/clock simulations, measuring phase noise from variable-step solver output, computing jitter, or resampling non-uniform data.

Analyzes the volatility smile and skew for a single options expiration, providing implied volatility curves, skew metrics, and shape classification to reveal market pricing of tail risk and directional fear.

Analyzing pre-change impact across vertical (dependency chains, files) and horizontal (pattern consistency, naming) dimensions. Use to estimate blast radius before a refactor. No code.

Monitors a watchlist of Kalshi prediction markets for price moves, volume spikes, resolution proximity, and kill-criterion triggers, with cross-venue arbitrage detection against paired Polymarket markets adjusted for fees and slippage.

WOLVERINE v2.0 — HYPE alpha hunter. Entry-only scanner, DSL-exit-only architecture. v1.1 lost -22.7% because the scanner's thesis exit chopped 25/27 trades before DSL could manage them. v2.0 removes thesis exit entirely. Scanner decides entries (score 8+, 4H/1H aligned, SM consensus). DSL manages all exits (wide Phase 1 for HYPE volatility, trailing tiers starting at +15% ROE). Leverage lowered to 7x. Max 4 entries/day. 3-hour cooldown between entries. DSL exit managed by plugin runtime via runtime.yaml.

Angular core patterns: standalone components, signals, inject, control flow, zoneless. Trigger: When creating Angular components, using signals, or setting up zoneless.

Audio spectrograms/features (mel, chroma, MFCC) via CLI.

PaLI-3: Smaller, Faster, Stronger

GRIZZLY v3.0 — BTC Alpha Hunter. Tightened configs. 7x leverage. 360-minute timeout. No thesis exit. Plugin runtime DSL.

Alert design and on-call practices — severity, runbooks, SLO burn-rate alerting, escalation. Use when designing alerts, writing runbooks, reducing alert fatigue, setting up escalation policies, implementing SLO-based alerting, or improving on-call processes.

AL performance optimization patterns for Business Central. Use when optimizing queries with SetLoadFields, working with FlowFields and CalcFields, profiling codeunits, or resolving performance issues.