Results for “chainalysis”

Process and analyze high-throughput sequencing data with deepTools for quality control, normalization, comparison, and publication-quality visualizations of ChIP-seq, RNA-seq, and ATAC-seq experiments.

Detects DNS tunneling by computing Shannon entropy of DNS query names, analyzing query length distributions, inspecting TXT record payloads, and identifying high subdomain cardinality using scapy for packet capture analysis.

Analyzes malware-generated network traffic from PCAP files to identify C2 protocols, data exfiltration, DNS tunneling, and beaconing patterns using Wireshark, Zeek, Suricata, and Python.

Analyze proteomics and metabolomics mass spectrometry data with PyOpenMS: read/write MS file formats, process spectra, detect and quantify features, identify peptides and proteins, and run end-to-end LC-MS/MS pipelines using ready-to-run scripts.

Catalysis Based Testing Skill

Catalysis Design Expert Skill

Applies medicinal-chemistry filters with the medchem library — drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, and molecular complexity metrics for compound prioritization and library cleanup. Use when filtering or triaging a compound library, flagging PAINS or reactive groups, or assessing drug-likeness of candidate molecules. Part of the AlterLab Academic Skills suite.

Apply medicinal chemistry filters for compound triage: drug-likeness rules (Lipinski, Veber, CNS), structural alert catalogs (PAINS, NIBR, ChEMBL), complexity metrics, and a custom query language for library filtering.

Predict molecular properties, train graph neural networks, and run drug discovery workflows using DeepChem's featurizers, models, and MoleculeNet benchmarks.

Python performance profiling with cProfile, tracemalloc, and line_profiler. Use for identifying bottlenecks and memory issues. USE WHEN: user mentions "Python profiling", "cProfile", "memory profiling", asks about "Python performance", "tracemalloc", "line_profiler", "py-spy", "Python optimization", "Python memory leak" DO NOT USE FOR: Java/Node.js profiling - use respective skills instead

Investigate supply chain attack artifacts including trojanized software updates, compromised build pipelines, and sideloaded dependencies to identify intrusion vectors and scope of compromise.

Spectral similarity and compound identification for metabolomics. Use for comparing mass spectra, computing similarity scores (cosine, modified cosine), and identifying unknown compounds from spectral libraries. Best for metabolite identification, spectral matching, library searching. For full LC-MS/MS proteomics pipelines use pyopenms.

Convert chemical structures (SMILES or RDKit molecules) into numerical representations for machine learning using 100+ featurizers, including ECFP, MACCS, descriptors, and pretrained models like ChemBERTa.

Detect and humanize AI-generated Chinese text. 20+ rule detection categories plus statistical features (sentence-length CV, short-sentence fraction, comma density, perplexity, GLTR, DivEye) plus scene-aware LR fusion (rule × 0.2 + LR × 0.8) trained on three scenes: general / academic / longform 长文本 (≥1500 字)。Unified CLI: ./humanize {detect,rewrite,academic,style,compare}. 8 style transforms (casual/zhihu/xiaohongshu/wechat/academic/literary/weibo/novel)。 Multi-paragraph rewriting (paragraph length CV、跨段 trigram 重复) plus best-of-N humanize (默认 N=10 取最低 LR)。165 replacement patterns + CiLin 同义词词林 38873 with collision blacklist。 Academic paper AIGC reduction for CNKI/VIP/Wanfang (知网/维普/万方 AIGC 检测降重)。 Pure Python, no dependencies, offline。v5.0.0 — HC3 fused 准确率 95%、学术 hero 100→35 (-65)、 工作汇报 96→13 (-83)、长篇博客 96→41 (-55)。 Use when user says: "去AI味", "降AIGC", "人性化文本", "humanize chinese", "AI检测", "AIGC降重", "去除AI痕迹", "文本改写", "论文降重", "知网检测", "维普检测", "AI写作检测", "让文字更自然", "detect AI text", "humanize text", "reduce AIGC sc

丁磊（互联网创业）认知与表达框架（压缩蒸馏）：佛系老板、游戏与音乐品味人设 触发：网易、养猪梗 等。非替网易发言

袁朗（军旅剧虚构）认知与表达框架（压缩蒸馏）：老 A 冷血人设、试探与打磨、精英残酷浪漫 触发：士兵突击 等。虚构

Python interface to OpenMS for mass spectrometry data analysis. Use for LC-MS/MS proteomics and metabolomics workflows including file handling (mzML, mzXML, mzTab, FASTA, pepXML, protXML, mzIdentML), signal processing, feature detection, peptide identification, and quantitative analysis. Apply when working with mass spectrometry data, analyzing proteomics experiments, or processing metabolomics datasets.

Clusters raw detection tickets into reusable edge concepts with thesis, invalidation signals, and strategy playbooks before strategy design.

NGS analysis toolkit. BAM to bigWig conversion, QC (correlation, PCA, fingerprints), heatmaps/profiles (TSS, peaks), for ChIP-seq, RNA-seq, ATAC-seq visualization.

Query ChEMBL via the chembl_webresource_client Python client for curated bioactive molecules and drug-like compound libraries at scale — search compounds by structure or physicochemical properties, retrieve bioactivity measurements (IC50, Ki, EC50), and find inhibitors of a target. Use when screening chemical libraries, mining curated bioactivity for a protein, running SAR studies, or sourcing medicinal-chemistry data; for measured protein-ligand binding affinities (Ki/Kd/IC50) prefer alterlab-bindingdb instead. Part of the AlterLab Academic Skills suite.

Multi-perspective dialectical reasoning with cross-evaluative synthesis. Spawns parallel evaluative lenses (STRUCTURAL, EVIDENTIAL, SCOPE, ADVERSARIAL, PRAGMATIC) that critique thesis AND critique each other's critiques, producing N-squared evaluation matrix before recursive aggregation. Triggers on /critique, /dialectic, /crosseval, requests for thorough analysis, stress-testing arguments, or finding weaknesses. Implements Hegelian refinement enhanced with interleaved multi-domain evaluation and convergent synthesis.

实现问题分析和技能调用的完整思考链路，支持AI快速识别和调用合适的技能。

Applied Catalysis Design Skill

Chains Salesforce Batch Apex jobs via finish() callbacks, Flex Queue guards, or a Queueable coordinator, with guidance on state passing and test limitations.

Build complete mass-spectrometry workflows with pyOpenMS — feature detection, peptide identification, protein quantification, and full LC-MS/MS pipelines across many MS file formats (mzML, mzXML) and algorithms. Use for comprehensive proteomics and MS data processing — for simple spectral comparison and metabolite identification use matchms. Part of the AlterLab Academic Skills suite.

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.