Results for “gnomad”

Query gnomAD (Genome Aggregation Database) for population allele frequencies and gene constraint scores (pLI, LOEUF) reflecting loss-of-function intolerance. Use when checking how common a variant is across populations, filtering rare-disease candidate variants, assessing variant pathogenicity, or identifying loss-of-function intolerant genes. Part of the AlterLab Academic Skills suite.

DEPRECATED — consolidated into bmad-architecture create intent - this skill will be removed in v7 in favor of `bmad-architecture`.

杰诺斯（少年漫）认知与表达框架（压缩蒸馏）：改造人认真、战损美学、师徒忠犬 触发：一拳超人 等。虚构

SKILL.md is an open specification released by Anthropic in 2025 that standardizes how tools discover and auto-invoke procedural knowledge (skills, patterns, guides, rules). Instead of each tool (Claude, Cursor, VSCode, CLI) maintaining isolated skill registries, SKILL.md enables a single skill to be published once and auto-invoked across any tool that speaks the spec.

Build applications with Gemini API hosted models, including Gemini and Gemma 4, using multimodal content, function calling, structured outputs, and current SDKs for Python, JavaScript, Go, and Java.

Sets up {module-name} module in a project. Use when the user requests to 'install {module-code} module', 'configure {module-name}', or 'setup {module-name}'.

Idiomatic Go patterns, best practices, and conventions for building robust, efficient, and maintainable applications.

沈墨（悬疑剧虚构）认知与表达框架（压缩蒸馏）：创伤反杀叙事、时代灰雾、钢琴意象 触发：漫长的季节 等。虚构；禁止犯罪模仿

袁朗（军旅剧虚构）认知与表达框架（压缩蒸馏）：老 A 冷血人设、试探与打磨、精英残酷浪漫 触发：士兵突击 等。虚构

KOMODO v1.0 — Momentum Event Consensus. Uses leaderboard_get_momentum_events (real-time threshold crossings) to detect when 2+ quality SM traders cross momentum thresholds on the same asset/direction within 60 minutes. Confirmed by market concentration + volume. Enters with the momentum. Replaces MANTIS v1.0 and SCORPION v1.1 (both used stale position data).

Recommends using NSAIDs or DMARDs instead of glucocorticoids for chronic inflammatory disease (e.g., rheumatoid arthritis) to limit weight gain. Triggered when clinicians ask, “What anti‑inflammatory should I choose for this RA patient to avoid weight gain?” or “Should I avoid steroids in this obese patient with RA?”

Create a committed per-feature spec under `docs/specs/YYYY-MM-DD-<slug>/{spec,tasks}.md` with frontmatter (status, created, owner, pr, tags). Promotes an ephemeral `.claude/plans/<name>.md` into a persistent, searchable artifact. Use when starting a feature that's larger than a one-shot PR.

NVIDIA NemoClaw plugin for secure sandboxed installation and orchestration of OpenClaw always-on AI assistants via OpenShell

Use to structure and tighten an NEJM Original Article into terse IMRAD — short main text (~2700 words), limited references, claim-first results, and a sober discussion with explicit limitations and calibrated clinical implications. Enforces NEJM's plain, concise house style.