Results for “marker-genes”

Single-cell RNA-seq analysis. Load .h5ad/10X data, QC, normalization, PCA/UMAP/t-SNE, Leiden clustering, marker genes, cell type annotation, trajectory, for scRNA-seq analysis.

Provides a single 0-100 cycle score blending VIX, SPY IV Rank, Put/Call ratio, and valuation percentile to determine offense vs. defense posture, based on Howard Marks' market cycle framework.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use when identifying cancer-specific genetic vulnerabilities, finding synthetic lethal interactions, checking whether a gene is essential in given cell lines, or validating oncology drug targets. Part of the AlterLab Academic Skills suite.

Diagnose monogenic and syndromic obesity in children and adolescents using a structured step-by-step algorithm. Use this skill whenever a clinician suspects a genetic cause of obesity, asks about leptin deficiency, MC4R mutation, POMC deficiency, PCSK1 deficiency, leptin receptor deficiency, Bardet-Biedl syndrome, Prader-Willi syndrome, Alström syndrome, or any case of early-onset severe obesity with hyperphagia. Also trigger for questions about targeted pharmacotherapy including setmelanotide or metreleptin, or when to order a genomic obesity panel. Cross-references the NHS Genomic Test Finder skill to surface the relevant R-code once a diagnosis is reached.

Query NCBI Gene via the E-utilities and Datasets APIs, searching by gene symbol or Gene ID and retrieving gene information (RefSeqs, GO terms, genomic locations, associated phenotypes) including batch lookups. Use when resolving gene symbols to IDs, annotating gene lists, or pulling functional and positional gene metadata for downstream analysis. Part of the AlterLab Academic Skills suite.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores, drug sensitivity data, and gene effect profiles to identify cancer-specific vulnerabilities, synthetic lethal interactions, and validate oncology drug targets.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.

Single-cell RNA-seq analysis. Load .h5ad/10X data, QC, normalization, PCA/UMAP/t-SNE, Leiden clustering, marker genes, cell type annotation, trajectory, for scRNA-seq analysis.

Author, lint, diff, and export Google's DESIGN.md design token spec files, including WCAG contrast validation.

Generate structured data markup (JSON-LD) for rich results, AI search visibility, and enhanced SERP features. Supports Article, FAQ, HowTo, Product, Review, LocalBusiness, Event, BreadcrumbList, Person, Organization, and more. Use when the user needs schema markup, structured data, rich snippets, JSON-LD, or wants to improve search appearance.

Queries the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biomedical relationships across genes, drugs, diseases, phenotypes, pathways, and biological processes. Use when exploring drug-disease or gene-disease links, building disease-centric knowledge subgraphs, or sourcing relations for drug repurposing and precision-medicine analyses. Part of the AlterLab Academic Skills suite.

Generate realistic mock data from descriptions, types, or schemas. Use when you need test data fast.

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Use when searching protein sequences against profile hidden Markov models (HMMs) such as Pfam or other HMM databases.

Generates synthetic brain MRI volumes using NVIDIA's NV-Generate-CTMR workflow, with configurable modality and random seed.

Sincroniza el registro central de skills con AGENTS.md y registry/AGENT_REGISTRY.md, detectando skills huérfanas o faltantes y auditando el ecosistema.

Diagnosing and fixing bimodal matching score distributions in MaxFuse

Primeiro agente do Time de Migração. Detecta o paradigma do sistema legado a partir das specs, infere o paradigma natural da stack alvo, alerta sobre gaps e força uma decisão consciente do usuário. Produz paradigm_decision.md, leitura obrigatória de todos os agentes posteriores. Ativação: /reversa-paradigm-advisor (geralmente invocado por /reversa-migrate).

Evaluation of BaSiC illumination correction caching - NOT RECOMMENDED for sparse markers. Trigger: optimizing BaSiC, caching illumination correction