Results for “precision-medicine”

Queries the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biomedical relationships across genes, drugs, diseases, phenotypes, pathways, and biological processes. Use when exploring drug-disease or gene-disease links, building disease-centric knowledge subgraphs, or sourcing relations for drug repurposing and precision-medicine analyses. Part of the AlterLab Academic Skills suite.

Use the pk-doctor skill to run the aggregator health check and resolve

Use for writing, reviewing, debugging, testing, or validating Python mpmath arbitrary-precision numerical code. Trigger on mpf, mpc, mp.dps, workdps, interval arithmetic, high-precision quadrature, root finding, special functions, matrices, inverse transforms, or precision/convergence failures. Do not use for ordinary NumPy vectorization, SymPy symbolic manipulation, decimal currency arithmetic, or machine-float code with no precision requirement.

Predict 3D binding poses of small molecule ligands to protein targets using diffusion-based molecular docking, supporting single complexes, batch processing, and virtual screening.

Manage CAPA investigations, root cause analysis, corrective action planning, and effectiveness verification for medical device quality management systems.

CAPA system management for medical device QMS. Covers root cause analysis, corrective action planning, effectiveness verification, and CAPA metrics. Use for CAPA investigations, 5-Why analysis, fishbone diagrams, root cause determination, corrective action tracking, effectiveness verification, or CAPA program optimization.

Kit de ferramentas de patologia computacional para análise de imagens de lâminas inteiras (WSI) e dados de imagem multiparamétrica. Use esta habilidade ao trabalhar com lâminas de histopatologia, imagens coradas com H&E, imunofluorescência multiplex (CODEX, Vectra), proteômica espacial, detecção/segmentação de núcleos, construção de gráficos de tecido ou treinamento de modelos ML em dados de patologia. Suporta 160+ formatos de lâmina incluindo Aperio SVS, NDPI, DICOM, OME-TIFF para fluxos de trabalho de patologia digital.

Apply medicinal chemistry filters for compound triage: drug-likeness rules (Lipinski, Veber, CNS), structural alert catalogs (PAINS, NIBR, ChEMBL), complexity metrics, and a custom query language for library filtering.

Create medical coding guides for billing accuracy. TRIGGERS - Use when user needs help with coding-guide related tasks.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores, drug sensitivity data, and gene effect profiles to identify cancer-specific vulnerabilities, synthetic lethal interactions, and validate oncology drug targets.

Diagnosing and fixing bimodal matching score distributions in MaxFuse

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.

CAPA system management for medical device QMS. Covers root cause analysis, corrective action planning, effectiveness verification, and CAPA metrics. Use for CAPA investigations, 5-Why analysis, fishbone diagrams, root cause determination, corrective action tracking, effectiveness verification, or CAPA program optimization.

Filtros de química medicinal. Aplique regras de similaridade a fármacos (Lipinski, Veber), filtros PAINS, alertas estruturais, métricas de complexidade, para priorização de compostos e filtragem de bibliotecas.

在启动高风险项目或重要决策前，需要预先识别潜在失败点以增强心理韧性和方案鲁棒性时

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.

Create medical coding guides for billing accuracy. TRIGGERS - Use when user needs help with coding-guide related tasks.

Create patient intake forms with history and screening. TRIGGERS - Use when user needs help with intake-form related tasks.

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.

Access ClinPGx pharmacogenomics data (the successor to PharmGKB) to query gene-drug interactions, CPIC/DPWG dosing guidelines, drug labels, and pharmacogene records. Use when interpreting pharmacogenes (CYP2D6, CYP2C19, TPMT, DPYD, SLCO1B1), looking up genotype-guided drug dosing, checking PGx drug-safety associations (e.g. HLA-B*57:01 and abacavir), or supporting precision medicine and clinical pharmacogenomics decisions. For star-allele definitions/frequencies see PharmVar; for germline/somatic variant pathogenicity see alterlab-clinvar. Part of the AlterLab Academic Skills suite.