Results for “uk-biobank”

Generate typed SDK bindings (Pydantic v2 models, TypeScript types) from the Bloodbank JSON Schema tree at `bloodbank/schemas/bloodbank/v1/**` (Draft 2020-12). Uses `datamodel-code-generator` and `json-schema-to-typescript` — NOT the deprecated hand-rolled Holyfields generators. Use when generating event-contract bindings for a Bloodbank consumer, importing typed CloudEvents envelopes into another project, or scaffolding a `bloodbank-contracts` SDK package. Trigger keywords — "bloodbank SDK", "bloodbank contracts", "Pydantic from bloodbank schemas", "TypeScript types for bloodbank events", "bloodbank.v1.* types", "event contract bindings", "datamodel-code-generator", "json-schema-to-typescript", "regenerate SDK", "CloudEvents bindings". Do NOT use for schema authoring (edit `bloodbank/schemas/` directly per `docs/event-naming.md` §12), runtime envelope validation (use `BLOODBANK_HOOK_VALIDATE=1`), schema-tree consistency (`mise run smoketest:schemas`), or generic JSON Schema codegen unrelated to Bloodbank.

Query ChEMBL via the chembl_webresource_client Python client for curated bioactive molecules and drug-like compound libraries at scale — search compounds by structure or physicochemical properties, retrieve bioactivity measurements (IC50, Ki, EC50), and find inhibitors of a target. Use when screening chemical libraries, mining curated bioactivity for a protein, running SAR studies, or sourcing medicinal-chemistry data; for measured protein-ligand binding affinities (Ki/Kd/IC50) prefer alterlab-bindingdb instead. Part of the AlterLab Academic Skills suite.

Botany Debugging Expert Skill

Biological data toolkit. Sequence analysis, alignments, phylogenetic trees, diversity metrics (alpha/beta, UniFrac), ordination (PCoA), PERMANOVA, FASTA/Newick I/O, for microbiome analysis.

Botany Based Debugging Skill

Manage, annotate, and trace biological data with LaminDB, an open-source FAIR data framework that makes datasets queryable, versioned, and reproducible. Use when registering or querying biological datasets (scRNA-seq, spatial, flow cytometry), validating and curating data against ontologies (genes, cell types, diseases, tissues), tracking data lineage and computational workflows, building data lakehouses, or wiring integrations with Nextflow, Snakemake, W&B, or MLflow. Part of the AlterLab Academic Skills suite.

Use when converting GenBank format files to table format as part of the Entrez Direct toolkit from bioconda.

Analyze biological sequences, alignments, phylogenetic trees, and diversity metrics (alpha/beta, UniFrac) with ordination (PCoA) and PERMANOVA for microbiome and community ecology data.

Botany Testing Expert Skill

Query documented public database APIs with explicit endpoints, filters, pagination, and provenance for reproducible retrieval of scientific, regulatory, or financial facts.

Applied Botany Analysis Skill

Applied Botany Synthesis Skill

Botany Testing Advanced Skill

Biopython is a comprehensive set of freely available Python tools for biological computation. It provides functionality for sequence manipulation, file I/O, database access, structural bioinformatics, phylogenetics, and many other bioinformatics tasks.

Provides reference documentation and code patterns for Biopython, covering sequence handling, alignments, NCBI database access, BLAST, protein structures, phylogenetics, and other bioinformatics tasks.

Applied Botany Testing Skill

Look up NHS England genomic tests for rare and inherited diseases. Use this skill whenever a clinician asks what genetic test to order for a condition, which genes are covered for a specific diagnosis, what commissioning category a genomic test falls under (Core, Specialised, or Highly Specialised), or which tests belong to a specialty group (Neurology, Cardiology, Endocrinology, etc.). Also trigger for questions like what panel is used for a condition, whether there is an NHS test for something, what the R number is for a condition, or whether anything has changed in the genomic test directory. Source: NHS England National Genomic Test Directory for Rare and Inherited Disease v9.0 (April 2026).

Structured policy briefing note (1-2 pages). Issue, background, analysis, options, recommendation. UK GES, Australian Treasury, consulting formats. Auto-populates from econstack data skills.

Use when searching NCBI Entrez databases (pubmed, gene, protein, nuccore, snp, geoprofiles) with query strings and field qualifiers to retrieve record UIDs for downstream processing.

A股智能分析与智能选股工具。维护动态股票池(最多30支),按高科技×中小市值×好业绩原则筛选,推送买卖信号。含独立技术面择时分(-10~+10)用于判断买卖时机。A股投资、股市分析、量化选股。

Fix 8-action space bug in backtest engines and rewrite backtest notebook for Colab v4.0.0