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This skill should be used when the user asks for "browser tests", "playwright tests", "end-to-end testing", "test user flows", "E2E coverage", "integration tests for UI", "page object pattern", "/e2e command", or discusses automated browser testing. Covers the E2E test loop workflow, Playwright patterns, page objects, and selector strategies.

Query NCBI ClinVar via the E-utilities API or FTP for the clinical significance (pathogenicity) of human germline genetic variants, searching by gene, variant, condition, or genomic position and interpreting ACMG/AMP classifications and review-status star ratings. Use when assessing whether a variant is pathogenic, likely pathogenic, VUS, likely benign, or benign, resolving conflicting interpretations, or annotating a VCF with ClinVar clinical significance. For population allele frequencies by ancestry use alterlab-gnomad; for somatic cancer mutation frequencies use alterlab-cosmic. Part of the AlterLab Academic Skills suite.