Results for “sui”

Provides the RDKit cheminformatics toolkit for low-level, fine-grained molecular primitives — SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure/SMARTS search, 2D/3D coordinate generation, similarity, and reaction handling. Use when custom sanitization, specialized fingerprint or descriptor algorithms, reaction enumeration, or conformer generation demand direct API control; for a high-level pandas-friendly wrapper over RDKit prefer alterlab-datamol, and for turning molecules into ML feature vectors prefer alterlab-molfeat. Part of the AlterLab Academic Skills suite.

Build, slice, concatenate, read, and write AnnData annotated data matrices (obs, var, X, layers, obsm, uns) — the scverse data STRUCTURE, not an analysis pipeline. Use when creating or wrangling .h5ad/zarr files, managing cell and gene annotations, concatenating batches, or handling layers/obsm/backed-mode; for the QC, normalization, clustering, UMAP, and differential-expression analysis pipeline prefer alterlab-scanpy instead, and for RNA velocity from spliced/unspliced layers prefer alterlab-scvelo instead. Part of the AlterLab Academic Skills suite.

Bun JavaScript runtime. Fast all-in-one toolkit with bundler, test runner, package manager. Use when working with Bun projects or considering Node.js alternatives. USE WHEN: user mentions "bun", "bun test", "bun build", asks about "Bun.serve", "bun install", "SQLite in Bun", "bunx", "performance comparison" DO NOT USE FOR: Node.js runtime - use `nodejs` skill instead DO NOT USE FOR: Hono/Elysia frameworks - use framework-specific skills DO NOT USE FOR: Language syntax - use `typescript` or `javascript` skills

Modern C++ (C++17/20/23) language and standard library. Covers RAII, move semantics, smart pointers, templates, concepts, ranges, coroutines, modules, std::expected, std::format, std::span, std::string_view. USE WHEN: user mentions "C++", "modern C++", "C++17/20/23", "RAII", "smart pointers", "templates", "concepts", "ranges", "move semantics", "std::expected", "std::span", "coroutines", "modules", "STL" DO NOT USE FOR: C (use a C-specific skill), C# (use `csharp`), Objective-C++, Carbon, kernel/no-exception subset (use `cpp-systems`)

Access ClinPGx pharmacogenomics data (the successor to PharmGKB) to query gene-drug interactions, CPIC/DPWG dosing guidelines, drug labels, and pharmacogene records. Use when interpreting pharmacogenes (CYP2D6, CYP2C19, TPMT, DPYD, SLCO1B1), looking up genotype-guided drug dosing, checking PGx drug-safety associations (e.g. HLA-B*57:01 and abacavir), or supporting precision medicine and clinical pharmacogenomics decisions. For star-allele definitions/frequencies see PharmVar; for germline/somatic variant pathogenicity see alterlab-clinvar. Part of the AlterLab Academic Skills suite.

Builds INTERACTIVE charts with the Plotly Python library (plotly.express / graph_objects) — hover tooltips, zoom/pan, animations, rangesliders, 3D rotation, and standalone HTML/web-embeddable output. Use when a chart must be interactive or web-embedded, for dashboards (incl. Dash), exploratory data analysis, or rotatable 3D plots. For static publication figures defer to alterlab-matplotlib; for static statistical charts (heatmaps, distributions) defer to alterlab-seaborn; for diagrams/schematics defer to alterlab-scientific-viz. Part of the AlterLab Academic Skills suite.

Breaks natural-language problem descriptions into sub-tasks suitable for DAG nodes. The entry point of the meta-DAG. Identifies phases, dependencies, parallelization opportunities, and vague/pluripotent nodes that can't yet be specified. Uses domain meta-skills when available. Activate on "decompose task", "break down problem", "plan workflow", "what are the steps", "sub-tasks", "task breakdown". NOT for executing the decomposed tasks (use dag-runtime), building the DAG structure (use dag-planner), or matching skills to nodes (use dag-skills-matcher).

Amazon SQS managed message queue service. Covers standard and FIFO queues, dead-letter queues, and integration patterns. Use for AWS-native serverless and microservices architectures. USE WHEN: user mentions "sqs", "aws queues", "fifo queue", "lambda trigger", "sns to sqs", asks about "aws messaging", "serverless queues", "standard queue", "visibility timeout" DO NOT USE FOR: event streaming - use `kafka` or AWS Kinesis; Azure-native - use `azure-service-bus`; GCP-native - use `google-pubsub`; on-premise - use `rabbitmq` or `activemq`; complex routing - use `rabbitmq`

Apache Kafka event streaming platform. Covers producers, consumers, topics, partitions, Kafka Streams, and Connect. Use for high-throughput event-driven architectures and real-time data pipelines. USE WHEN: user mentions "kafka", "event streaming", "kafka streams", "consumer groups", "topic partitions", asks about "high throughput messaging", "event sourcing", "log aggregation", "real-time pipelines" DO NOT USE FOR: simple queues - use `rabbitmq` or `activemq`; cloud-native lightweight - use `nats`; AWS-native - use `sqs`; Azure-native - use `azure-service-bus`; GCP-native - use `google-pubsub`

Caching strategies across the RAG stack. Semantic caching with GPTCache and LangChain, Redis-based embedding-similarity cache, cache key design, TTL/invalidation, partial caching (cache retrieval only), provider-native prompt caching (Anthropic, OpenAI), and hierarchical L1/L2 caches. USE WHEN: user mentions "semantic cache", "GPTCache", "LLM cache", "prompt caching", "Redis vector cache", "cache invalidation for RAG", "reduce LLM cost", "latency reduction LLM" DO NOT USE FOR: retrieval accuracy - use `rag-patterns`; groundedness checks - use `rag-guardrails`; incremental indexing - use `rag-production`

Loads Therapeutics Data Commons (TDC, PyTDC) AI-ready drug-discovery datasets and benchmarks — ADME, toxicity, drug-target interaction (DTI), scaffold splits, and molecular oracles for therapeutic ML and pharmacological prediction. Use when fetching a standardized benchmark dataset, applying scaffold or cold-split evaluation, or sourcing labeled molecules for ADMET, toxicity, or DTI modeling. Sources data, splits, and oracles only — defer molecular featurization (ECFP/fingerprints), model training, and transformers to a molecular-ML skill (e.g. deepchem). Part of the AlterLab Academic Skills suite.

Runs high-performance genomic interval analysis with gtars (databio), a Rust toolkit with Python bindings — the performance-critical backend for the geniml ML library. Use when computing overlaps/jaccard/coverage between BED region sets, indexing intervals with IGD, generating uniwig accumulation/coverage tracks, tokenizing genomic regions for ML, splitting single-cell fragments into pseudobulks, or computing GA4GH refget sequence digests. NOT for training region embeddings (use alterlab-geniml) or non-genomic spatial joins (use alterlab-geopandas). Part of the AlterLab Academic Skills suite.

Orchestrates the full academic research pipeline (research, write, integrity check, review, revise, re-review, re-revise, final integrity check, finalize), coordinating alterlab-deep-research, alterlab-paper-writer, and alterlab-paper-reviewer into a seamless 10-stage workflow with mandatory integrity verification, two-stage peer review, and reproducible quality gates. Use when the request mentions academic pipeline, research to paper, full paper workflow, paper pipeline, end-to-end paper, research-to-publication, or complete paper workflow. Part of the AlterLab Academic Skills suite.

Knowledge-graph-augmented retrieval. Entity and triple extraction, graph construction (Neo4j, LlamaIndex PropertyGraphIndex), hierarchical community summarization (Microsoft GraphRAG), personalized PageRank (HippoRAG), multi-hop traversal retrieval, and hybrid graph + vector pipelines. USE WHEN: user mentions "GraphRAG", "HippoRAG", "knowledge graph RAG", "entity extraction", "multi-hop reasoning", "Neo4j RAG", "LlamaIndex property graph", "LangChain graph retriever", "triple extraction", "community summarization" DO NOT USE FOR: vanilla vector RAG - use `rag-patterns`; multimodal inputs - use `multimodal-rag`; production indexing ops - use `rag-production`; hallucination checks - use `rag-guardrails`

Query the STRING API for protein-protein interactions (59M proteins, 20B interactions across 5000+ species), building interaction networks, discovering functional partners, and running GO/KEGG/Pfam enrichment on protein lists. Use when constructing a protein-protein interaction network, expanding from seed proteins to functional partners, or running PPI-based enrichment for systems biology; for curated metabolic pathway maps and reactions prefer alterlab-kegg, and for protein sequences, annotations, or accession ID mapping prefer alterlab-uniprot instead. Part of the AlterLab Academic Skills suite.

Run RNA velocity analysis with scVelo on single-cell RNA-seq data — estimate cell-state transitions from spliced/unspliced mRNA dynamics, infer trajectory direction, compute latent time, and identify driver genes. Use when adding directionality to trajectories or studying differentiation dynamics from spliced/unspliced layers (velocyto/STARsolo output); for the general QC, clustering, UMAP, and differential-expression analysis pipeline prefer alterlab-scanpy instead, and for .h5ad data-structure I/O and layer wrangling prefer alterlab-anndata instead. Part of the AlterLab Academic Skills suite.

Python language (3.10-3.14). Covers typing, async, and modern patterns. Use when writing Python applications. USE WHEN: user mentions "python", "type hints", "dataclasses", "async/await", asks about "asyncio", "context managers", "match statement", "walrus operator", "PEP 695", "type parameter", "generic" DO NOT USE FOR: FastAPI framework - use `backend-fastapi` skill instead DO NOT USE FOR: Django framework - use Django-specific skill DO NOT USE FOR: Package management - use `python-packaging` skill DO NOT USE FOR: Linting/type checking config - use `python-quality` skill

Kernel-Mode Driver Framework (KMDF), the Microsoft-recommended way to write Windows kernel-mode drivers. Covers DriverEntry, EvtDeviceAdd, IRPs and IOCTLs, I/O queues, PnP and Power state machines, IRQL discipline, memory pools, WPP tracing, SAL annotations, and Driver Verifier. USE WHEN: user mentions "KMDF", "WDF kernel", "Windows kernel driver", "DriverEntry", "WdfDriverCreate", "EvtDeviceAdd", "IRP", "IOCTL", "DISPATCH_LEVEL", "PASSIVE_LEVEL", "NTSTATUS", "PoolTag", "WdfRequestComplete" DO NOT USE FOR: UMDF v2 (use `wdf-umdf`), classic WDM-only drivers, file-system filters (FltMgr is a separate framework)

Run the standard single-cell RNA-seq analysis pipeline with Scanpy on AnnData — QC filtering, normalization, dimensionality reduction (PCA, UMAP, t-SNE), Leiden/Louvain clustering, marker/differential expression, PAGA trajectories, and plotting. Use when analyzing scRNA-seq data through clustering, cell-type annotation, DE, or pseudotime workflows; for building or reading the .h5ad data structure itself (layers, obs/var, concatenation, backed mode) prefer alterlab-anndata instead, and for RNA velocity from spliced/unspliced counts prefer alterlab-scvelo instead. Part of the AlterLab Academic Skills suite.

Simulates open quantum systems with QuTiP, the Quantum Toolbox in Python, solving Lindblad master equations (mesolve), Monte Carlo trajectories (mcsolve), and unitary dynamics (sesolve). Use when studying master-equation or Lindblad dynamics, decoherence, dissipation, quantum optics, cavity QED, or open-system time evolution. NOT for circuit-based quantum computing or hardware execution — for IBM Quantum circuits prefer alterlab-qiskit, for Google Quantum AI or NISQ circuits prefer alterlab-cirq, and for gradient-trained quantum ML prefer alterlab-pennylane. Part of the AlterLab Academic Skills suite.

Provide direct REST API access to KEGG (academic use only) for pathway analysis, gene-to-pathway and compound-to-pathway mapping, metabolic reactions, KEGG Orthology (KO), drug-drug interactions, and ID conversion. Use when querying KEGG pathways, mapping genes/compounds to metabolic maps, or running KEGG pathway enrichment via raw HTTP/REST; for protein-protein interaction networks prefer alterlab-string-db, for protein sequences and annotations prefer alterlab-uniprot, and for Python workflows spanning many databases prefer bioservices instead. Part of the AlterLab Academic Skills suite.

Builds, simulates, and runs quantum circuits with Cirq, Google Quantum AI's framework for NISQ hardware, noise-aware low-level circuit design, and noise characterization. Use when targeting Google Quantum AI processors (Sycamore/Weber), designing noise-aware NISQ circuits, or running characterization experiments (randomized benchmarking, XEB). For IBM Quantum hardware and Qiskit Runtime prefer alterlab-qiskit; for gradient-trained quantum ML and hybrid quantum-classical models prefer alterlab-pennylane; for open-system Lindblad/master-equation dynamics prefer alterlab-qutip. Part of the AlterLab Academic Skills suite.

Creates, analyzes, and visualizes complex networks and graphs in Python with NetworkX. Use when working with network/graph data structures, analyzing relationships between entities, computing graph algorithms (shortest paths, centrality, clustering), detecting communities, generating synthetic networks, or visualizing topologies — applicable to social, biological, transportation, citation, and any pairwise-relationship networks. This is classical graph analytics, not deep learning — for training graph neural networks (GCN/message passing, node/edge/graph classification on Cora-style data) use alterlab-torch-geometric instead. Part of the AlterLab Academic Skills suite.

Access the AlphaFold DB of 200M+ AI-PREDICTED protein structures — retrieve models by UniProt accession, download PDB/mmCIF files, and analyze prediction confidence metrics (pLDDT, PAE). Use when a UniProt ID needs a computationally predicted 3D structure or when no experimental structure exists, for homology modeling, protein engineering, or structure-based drug discovery; for EXPERIMENTALLY determined structures (X-ray, cryo-EM, NMR) prefer alterlab-pdb, and for protein sequences, annotations, or accession ID mapping prefer alterlab-uniprot instead. Part of the AlterLab Academic Skills suite.

Kotlin language fundamentals. Covers null safety, coroutines, flow, sealed classes, data classes, scope functions, and Kotlin 2.x features (K2 compiler, context parameters). Use for Kotlin/JVM, Kotlin/Native, Kotlin/JS work. USE WHEN: user mentions "Kotlin", "coroutines", "suspend", "Flow", "sealed class", "data class", "scope functions", "K2 compiler", "ksp", "Kotlin 2.x" DO NOT USE FOR: Kotlin Multiplatform setup - use `mobile/kotlin-multiplatform` DO NOT USE FOR: Compose UI - use `frontend-frameworks/compose-multiplatform` DO NOT USE FOR: Spring Boot Kotlin - use `spring-boot` framework skill

User-Mode Driver Framework v2 (UMDF). User-mode driver model that uses the same WDF object model as KMDF but runs in a host process (WUDFHost.exe) protected by the reflector. Required for some categories (Indirect Display Drivers, many sensor and camera drivers) and recommended for any driver that doesn't strictly need kernel mode. USE WHEN: user mentions "UMDF", "WUDFHost", "user-mode driver", "reflector", "IDD", "ISensor", "WDFHOST", "UMDF v2", "FX2" DO NOT USE FOR: KMDF (use `wdf-kmdf`), classic UMDF v1 (deprecated, COM-based)

Builds, transpiles, and runs quantum circuits with Qiskit, IBM's quantum computing framework, including Qiskit Runtime primitives (Sampler/Estimator), circuit transpilation, and error mitigation on IBM Quantum hardware. Use when targeting IBM Quantum backends, transpiling circuits, running Runtime sessions or batches, or applying resilience/error mitigation. For Google Quantum AI hardware and NISQ circuits prefer alterlab-cirq; for gradient-trained quantum ML and hybrid quantum-classical models prefer alterlab-pennylane; for open-system Lindblad/master-equation dynamics prefer alterlab-qutip. Part of the AlterLab Academic Skills suite.

Extract and preprocess tiles from whole-slide images (WSI) with histolab — OpenSlide-backed slide loading, tissue detection and masks, Random/Grid/Score tile extraction, and image/morphological filters for H&E preprocessing. Use when the user needs lightweight WSI slide preprocessing — building tile datasets for ML training, tissue segmentation, or quick tile-based inspection of histopathology slides. For end-to-end computational-pathology, deep-learning model training, nucleus segmentation, or multiplexed/spatial-proteomics (CODEX, Vectra) pipelines prefer alterlab-pathml instead. Part of the AlterLab Academic Skills suite.

Query NCBI ClinVar via the E-utilities API or FTP for the clinical significance (pathogenicity) of human germline genetic variants, searching by gene, variant, condition, or genomic position and interpreting ACMG/AMP classifications and review-status star ratings. Use when assessing whether a variant is pathogenic, likely pathogenic, VUS, likely benign, or benign, resolving conflicting interpretations, or annotating a VCF with ClinVar clinical significance. For population allele frequencies by ancestry use alterlab-gnomad; for somatic cancer mutation frequencies use alterlab-cosmic. Part of the AlterLab Academic Skills suite.

Featurizes molecules for machine learning with molfeat (100+ featurizers) — ECFP/MACCS/MAP4 fingerprints, RDKit and Mordred physicochemical descriptors, and pretrained embeddings (ChemBERTa, ChemGPT, GIN) exposed as scikit-learn transformers that convert SMILES into feature vectors. Use when turning molecules into ML-ready feature matrices for QSAR/QSPR or virtual screening, or benchmarking fingerprint against descriptor and embedding representations; for training models and MoleculeNet benchmarks on those features prefer alterlab-deepchem, and for low-level fingerprint or descriptor primitives prefer alterlab-rdkit. Part of the AlterLab Academic Skills suite.

Query the GTEx (Genotype-Tissue Expression) portal v2 REST API for tissue-specific gene expression (median TPM across 54 human tissues), expression QTLs (eQTLs), and splicing QTLs (sQTLs). Use when checking which tissues express a gene, finding which gene a non-coding/GWAS variant regulates via eQTLs, or interpreting variant regulatory effects across tissues. NOT for curated trait-variant associations (use alterlab-gwas), population allele frequencies or variant constraint (use alterlab-gnomad), or gene/transcript structure and ID mapping (use alterlab-ensembl). Part of the AlterLab Academic Skills suite.

Provide direct REST API access to UniProt (Swiss-Prot/TrEMBL) for protein sequence searches, FASTA retrieval, functional annotations (GO terms, domains), and cross-database ID mapping. Use when looking up a protein entry, fetching a protein FASTA sequence, or mapping accessions between databases over raw HTTP/REST; for EXPERIMENTAL 3D structures prefer alterlab-pdb, for AI-PREDICTED 3D structures prefer alterlab-alphafold-db, for protein-protein interaction networks prefer alterlab-string-db, and for Python workflows spanning many databases prefer bioservices instead. Part of the AlterLab Academic Skills suite.

Supervises theses and dissertations end to end — structure guidance from proposal through defense, chapter-by-chapter writing support (introduction, literature review, methodology, results, discussion), supervision strategies, committee management, defense and viva voce preparation, timeline planning, feedback integration, examiner-expectation guidance, and formatting (APA 7, Chicago, university styles). Use when the request mentions thesis, dissertation, supervision, defense preparation, viva, proposal defense, thesis structure, thesis chapter, literature review chapter, methodology chapter, results chapter, discussion chapter, thesis timeline, committee, thesis formatting, or dissertation proposal. Part of the AlterLab Academic Skills suite.

Machine learning on genomic interval data (BED files) with the geniml Python package — region embeddings (Region2Vec), joint region+metadata embeddings (BEDspace/StarSpace), single-cell ATAC-seq embeddings (scEmbed), consensus peak sets / universes (build-universe), tokenization, BEDshift randomization, and BBClient/BEDbase caching. Use when training or using region/cell embeddings, clustering scATAC-seq, building a tokenization universe from BED collections, or any ML/feature-learning task over genomic regions. NOT for plain interval arithmetic (overlap/intersect/merge counts) — that is gtars, not geniml. Part of the AlterLab Academic Skills suite.

Swift language fundamentals (5.10+ / 6.x). Covers optionals, value vs reference semantics, protocols & generics, Swift Concurrency (async/await, actors, Sendable, structured tasks), Result Builders, and Apple platform interop. USE WHEN: user mentions "Swift", "SwiftUI", "async/await Swift", "actor", "Sendable", "Codable", "Combine", "Result Builder", "Apple Keychain", "Secure Enclave", "iOS native" DO NOT USE FOR: SwiftUI screen layouts in depth - use SwiftUI-specific skill if exists DO NOT USE FOR: Compose iOS via Skia - use `frontend-frameworks/compose-multiplatform` DO NOT USE FOR: Kotlin/Native ↔ Swift bridging - use `languages/uniffi`

Create cross-platform agent skills from workflow descriptions. Activates when users ask to create an agent, automate a repetitive workflow, create a custom skill, or need advanced agent creation. Triggers on phrases like create agent for, automate workflow, create skill for, every day I have to, daily I need to, turn process into agent, need to automate, create a cross-platform skill, validate this skill, export this skill, migrate this skill. Supports single skills, multi-agent suites, transcript processing, template-based creation, interactive configuration, cross-platform export, and spec validation.