All Skills

Cheminformatics toolkit for fine-grained molecular control. SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D generation, similarity, reactions. For standard workflows with simpler interface, use datamol (wrapper around RDKit). Use rdkit for advanced control, custom sanitization, specialized algorithms.

Autonomous biomedical AI agent framework for executing complex research tasks across genomics, drug discovery, molecular biology, and clinical analysis. Use this skill when conducting multi-step biomedical research including CRISPR screening design, single-cell RNA-seq analysis, ADMET prediction, GWAS interpretation, rare disease diagnosis, or lab protocol optimization. Leverages LLM reasoning with code execution and integrated biomedical databases.

Creating interactive data visualisations using d3.js. This skill should be used when creating custom charts, graphs, network diagrams, geographic visualisations, or any complex SVG-based data visualisation that requires fine-grained control over visual elements, transitions, or interactions. Use this for bespoke visualisations beyond standard charting libraries, whether in React, Vue, Svelte, vanilla JavaScript, or any other environment.

Interact with GitHub using the `gh` CLI. Use `gh issue`, `gh pr`, `gh run`, and `gh api` for issues, PRs, CI runs, and advanced queries.

Best practices for using the oracle CLI (prompt + file bundling, engines, sessions, and file attachment patterns).

Single-cell RNA-seq analysis. Load .h5ad/10X data, QC, normalization, PCA/UMAP/t-SNE, Leiden clustering, marker genes, cell type annotation, trajectory, for scRNA-seq analysis.

This skill should be used when working with annotated data matrices in Python, particularly for single-cell genomics analysis, managing experimental measurements with metadata, or handling large-scale biological datasets. Use when tasks involve AnnData objects, h5ad files, single-cell RNA-seq data, or integration with scanpy/scverse tools.

Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.

Search GIF providers with CLI/TUI, download results, and extract stills/sheets.

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.

Statistical visualization. Scatter, box, violin, heatmaps, pair plots, regression, correlation matrices, KDE, faceted plots, for exploratory analysis and publication figures.

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Firebase gives you a complete backend in minutes - auth, database, storage, functions, hosting. But the ease of setup hides real complexity. Security rules are your last line of defense, and they're often wrong. Firestore queries are limited, and you learn this after you've designed your data model. This skill covers Firebase Authentication, Firestore, Realtime Database, Cloud Functions, Cloud Storage, and Firebase Hosting. Key insight: Firebase is optimized for read-heavy, denormalized data. I

Plan UX patterns and design specifications. Use when the user says "lets create UX design" or "create UX specifications" or "help me plan the UX"

Product manager for PRD creation and requirements discovery. Use when the user asks to talk to John or requests the product manager.

Authors and updates customization overrides for installed BMad skills. Use when the user says 'customize bmad', 'override a skill', 'change agent behavior', or 'customize a workflow'.

Pressure-test an idea through persona-driven interrogation until it hardens, proves out, or dies cheaply. Use when the user says 'forge an idea', 'pressure-test this idea', 'stress-test my thinking', or 'harden this idea'.

Integrate services or agent harnesses with the 33GOD Bloodbank event bus. Covers schemas in Bloodbank schemas/ and docs/event-naming.md, producing events (NATS preferred; Dapr, HTTP /publish, hookd_bridge alternatives), consuming events (NATS, Dapr, FastStream, event-toaster), and agent hook wiring through the canonical services/agent-hooks publisher. Use for event publish/consume, authoring schemas, integrating harnesses (Claude Code, Copilot CLI, OpenCode, Cursor, Aider, Codex CLI, Hermes), or debugging missing envelopes. Triggers: bloodbank, event bus, publish, subscribe, NATS subject, holyfields legacy, CloudEvents, event-toaster, ntfy.delo.sh/bloodbank, bloodbank.v1.agent.session.started, bloodbank.v1.agent.tool.completed, bloodbank.cmd.v1.agent.invocation.start. Skip for generic brokers, n8n, hindsight memory, or non-event-bus 33GOD.

Builds, edits or analyzes Agent Skills through conversational discovery. Use when the user requests to "Create an Agent", "Analyze an Agent" or "Edit an Agent".

Manage significant changes during sprint execution. Use when the user says "correct course" or "propose sprint change"

Conduct market research on competition and customers. Use when the user says they need market research

Technical documentation specialist and knowledge curator. Use when the user asks to talk to Paige or requests the tech writer.

Apply systematic problem-solving methodologies to complex challenges. Use when the user says "guide me through structured problem solving" or "I want to crack this challenge with guided problem solving techniques"

Clinical copy-editor that reviews text for communication issues. Use when user says review for prose or improve the prose

Create project-context.md with AI rules. Use when the user says "generate project context" or "create project context"

Validate PRD, UX, Architecture and Epics specs are complete. Use when the user says "check implementation readiness".

Trigger: macOS UI, screen recording, simulator UI, desktop app click, capture screen, system dialog, macOS clipboard, menu bar, drag drop. Scope: Automate macOS GUI applications, drive input events, list windows/spaces, and capture visual state via Peekaboo CLI. Boundary: Excludes pure browser-level automation (use chrome-devtools instead) or headless server tasks.

Use when task matches aesthetic-rules aesthetic guidance for visual systems, style selection, and interface quality.

Use when task matches aesthetic-science aesthetic guidance for visual systems, style selection, and interface quality.

Trigger: PM, product tasks, project planning, backlog priority, user stories, ticket scoping. Scope: Product management, task priorities, requirements scoping. Boundary: Excludes writing raw code or designing page layouts.

Trigger: deployment pipeline, CI CD, Docker builds, DB migrations, expand contract database, Netlify. Scope: Application deployment, multi-stage builds, zero-downtime releases. Boundary: Excludes local editor settings.

Trigger: structured logging, tracing, telemetry, SLI metrics, SLO alerts, log formats. Scope: Performance metrics, error tracing, production telemetry. Boundary: Excludes client behavioral product funnels.

Trigger: empty list state, loader skeleton, error boundary layout, offline indicator, system fallback UI. Scope: UI fallback layouts, skeleton placeholders, client recovery views. Boundary: Excludes server-side API error status coding.

Trigger: press release, PM memo, PRD memo, product launch narrative, launch story. Scope: Writing press releases and future launch stories for project alignment. Boundary: Excludes writing functional code or task tracking.

Creates an outcome-backed product strategy memo from an Ideal Customer Profile markdown file, pasted ICP notes, discovery artifacts, product context, or PRD context. Use when asked to create product strategy, convert an UX Discovery and ICP into strategy, define vision-to-outcome strategy, turn discovery into strategic bets, clarify target customer outcomes, evaluate roadmap strategy, or avoid feature-factory planning.

Scaffold a new page from the site's template system (e.g., new course landing page)