Results for “allele-frequency”

Query gnomAD (Genome Aggregation Database) for population allele frequencies and gene constraint scores (pLI, LOEUF) reflecting loss-of-function intolerance. Use when checking how common a variant is across populations, filtering rare-disease candidate variants, assessing variant pathogenicity, or identifying loss-of-function intolerant genes. Part of the AlterLab Academic Skills suite.

BALD EAGLE v3.0 — XYZ Alpha Hunter (Hardened). Focused on 6 high-liquidity XYZ assets: CL, BRENTOIL, GOLD, SILVER, SP500, XYZ100. Conviction-scaled leverage (5-10x based on score). Wider DSL for macro assets. Maker-only execution. Scanner calls create_position internally. v3.0: focused assets, conviction-scaled leverage, XYZ-tuned DSL, no thesis exit.

Use when filling ancestral alleles into the INFO column of VCF files using ancestral alignment data from 1000 Genomes or similar sources.

Query gnomAD for population allele frequencies, constraint metrics, and loss-of-function intolerance. Use when interpreting variants, filtering common alleles, or prioritizing genes in rare disease workflows.

Orchestrate token-heavy research, coding, and testing by delegating bounded tasks to cheaper subagents while reserving Claude Fable for architecture, synthesis, and final review.

Analyze AMS waveform data using Mixed-Signal Blockset utilities: phase noise measurement, clock jitter, anti-aliased resampling, timing measurements, lock time, INL/DNL, ADC/DAC calibration, HSpice import. Use when analyzing time-domain voltage from PLL/VCO/clock simulations, measuring phase noise from variable-step solver output, computing jitter, or resampling non-uniform data.

Analyzes the volatility smile and skew for a single options expiration, providing implied volatility curves, skew metrics, and shape classification to reveal market pricing of tail risk and directional fear.

Head-to-head comparison of coding agents (Claude Code, Aider, Codex, etc.) on custom tasks with pass rate, cost, time, and consistency metrics

Apache Airflow, dbt, Prefect, Dagster, and modern data orchestration for production data pipelines

Benchmarks automatic post-editing (APE) models on WMT'18 SMT, SubEdits, and MLQE-PE datasets, reporting BLEU, ChrF, and TER scores computed with SacreBLEU and TERCOM.

Multi-source recency research skill that takes the pulse of any topic across Reddit, Hacker News, the open web, and optionally X/Twitter within a configurable recent window (default 30 days).

Autonomously optimize any Claude Code skill by running it repeatedly, scoring outputs against binary evals, mutating the prompt, and keeping improvements. Based on Karpathy's autoresearch methodology. Use when: optimize this skill, improve this skill, run autoresearch on, make this skill better, self-improve skill, benchmark skill, eval my skill, run evals on. Outputs: an improved SKILL.md, a results log, and a changelog of every mutation tried.

Operate and extend barretlee/agent-pulse, the evidence-backed AI industry intelligence system: inspect source catalog and lifecycle, collect and normalize signals, bind evidence, cluster Events, evaluate system health, generate Scout hypotheses, export the privacy-safe public site, and verify release gates. Use when the user asks to run, configure, debug, extend, or explain Agent Pulse, its collectors, Control Room, narratives, Scout, or GitHub Pages output. Triggers on: agent-pulse, Agent Pulse, evidence-backed intelligence, source catalog, signal collection, Event clustering, source audit, Scout opportunity, public export, weekly brief, or AI industry intelligence pipeline.

Compare coding agents head-to-head on reproducible tasks with pass rate, cost, time, and consistency metrics.

Analyzing pre-change impact across vertical (dependency chains, files) and horizontal (pattern consistency, naming) dimensions. Use to estimate blast radius before a refactor. No code.

Monitors a watchlist of Kalshi prediction markets for price moves, volume spikes, resolution proximity, and kill-criterion triggers, with cross-venue arbitrage detection against paired Polymarket markets adjusted for fees and slippage.

Econometrics skill for panel data models. Activates when the user asks about: "panel data", "fixed effects", "random effects", "Hausman test", "within estimator", "between estimator", "two-way fixed effects", "clustered standard errors panel", "FE model", "RE model", "pooled OLS", "unobserved heterogeneity", "panel regression", "first difference estimator", "entity fixed effects", "time fixed effects", "面板数据", "固定效应", "随机效应", "豪斯曼检验", "双向固定效应", "面板回归", "个体效应", "时间效应", "一阶差分"

Econometrics skill for panel data models. Activates when the user asks about: "panel data", "fixed effects", "random effects", "Hausman test", "within estimator", "between estimator", "two-way fixed effects", "clustered standard errors panel", "FE model", "RE model", "pooled OLS", "unobserved heterogeneity", "panel regression", "first difference estimator", "entity fixed effects", "time fixed effects", "面板数据", "固定效应", "随机效应", "豪斯曼检验", "双向固定效应", "面板回归", "个体效应", "时间效应", "一阶差分"

WOLVERINE v2.0 — HYPE alpha hunter. Entry-only scanner, DSL-exit-only architecture. v1.1 lost -22.7% because the scanner's thesis exit chopped 25/27 trades before DSL could manage them. v2.0 removes thesis exit entirely. Scanner decides entries (score 8+, 4H/1H aligned, SM consensus). DSL manages all exits (wide Phase 1 for HYPE volatility, trailing tiers starting at +15% ROE). Leverage lowered to 7x. Max 4 entries/day. 3-hour cooldown between entries. DSL exit managed by plugin runtime via runtime.yaml.

Evaluates open-ended generation quality of multilingual LLMs across brainstorming, planning, and long-form tasks, using AYA and DOLLY datasets with qualitative fluency and quality scoring.

Multi-source recency research skill that takes the pulse of any topic across Reddit, Hacker News, the open web, and optionally X/Twitter within a configurable recent window (default 30 days). Forcing intake clarifies topic specificity, angle (trend/sentiment/problems/opportunities/comparison), time window, and platform scope before searching. Returns a synthesized briefing with citations, engagement metrics, and cross-platform pattern analysis. Use when the user requests multi-source recency intelligence on a topic (e.g., 'pulse on [topic]', 'what's happening with [topic]', 'what are people saying about [topic]', 'current conversation about [topic]', 'take the pulse of [topic]', 'trending: [topic]', 'find me info on [topic]'), and for competitor research, trend discovery, tool comparisons, and audience sentiment analysis.

Angular core patterns: standalone components, signals, inject, control flow, zoneless. Trigger: When creating Angular components, using signals, or setting up zoneless.

Audio spectrograms/features (mel, chroma, MFCC) via CLI.

Compares coding agents head-to-head on reproducible tasks, measuring pass rate, cost, time, and consistency.

Head-to-head comparison of coding agents (Claude Code, Aider, Codex, etc.) on custom tasks with pass rate, cost, time, and consistency metrics

Runs a nightly automated retrospective on autonomous trading strategy performance, computing win rates, fee drag, holding period buckets, direction bias, and producing data-driven improvement suggestions.

Multi-source recency research skill that takes the pulse of any topic across Reddit, Hacker News, the open web, and optionally X/Twitter within a configurable recent window (default 30 days). Forcing intake clarifies topic specificity, angle (trend/sentiment/problems/opportunities/comparison), time window, and platform scope before searching. Returns a synthesized briefing with citations, engagement metrics, and cross-platform pattern analysis. Triggers: 'pulse on [topic]', 'what's happening with [topic]', 'what are people saying about [topic]', 'current conversation about [topic]', 'take the pulse of [topic]', 'trending: [topic]', 'find me info on [topic]', or any variation requesting multi-source recency intelligence on a topic. Also use for competitor research, trend discovery, tool comparisons, and audience sentiment analysis.

Agent skill for code-analyzer - invoke with $agent-code-analyzer

Financial analyst agent skill and plugin for Claude Code, Codex, Gemini CLI, Cursor, OpenClaw. Ratio analysis, DCF valuation, budget variance, rolling forecasts. 4 Python tools (stdlib-only).

Wire ETL, ingestion, cron, edge-function, and queue jobs correctly. Use for "build a pipeline", "sync X into Y", "nightly aggregation", "cron double-counts", "dedupe", "backfill", "the numbers are wrong after a retry". Bakes in idempotency, atomic writes, data contracts, dead-letter, and observability.

Head-to-head comparison of coding agents (Claude Code, Aider, Codex, etc.) on custom tasks with pass rate, cost, time, and consistency metrics

Identifies operational toil, prioritizes automation by ROI, and provides patterns for self-healing systems and runbook automation.

A funnel and account-scoring diagnostic engine for any sales org. Connect a CRM and a product-analytics tool (plus optional enrichment, community, and meeting tools). Three modes. (1) FUNNEL DIAGNOSIS finds leaky conversion gates by channel with per-stage leakage, dollarized leverage points, and cohort velocity. (2) SPRINT PLANNING enriches qualified accounts into a ranked backlog with verified buying committees. (3) SCORING AUDIT finds where your scoring model is missing real ICPs. Trigger on 'funnel diagnosis', 'diagnose the funnel', 'where are we leaking', 'why is [channel] underperforming', 'conversion by channel', 'sprint planning', 'score these accounts', 'find missed ICPs', 'audit the scoring model', or any channel-level cohort-conversion, account-prioritization, or scoring-gap question.

Head-to-head comparison of coding agents (Claude Code, Aider, Codex, etc.) on custom tasks with pass rate, cost, time, and consistency metrics

ACME protocol and SSL/TLS certificate automation reference. Covers challenge types (HTTP-01, DNS-01, TLS-ALPN-01), major clients (certbot, acme.sh, lego, Caddy), certificate lifecycle management, Kubernetes cert-manager, Docker/Traefik integration, and security best practices.