Results for “clinical-relevance”

Use this first, before any writing, to stress-test whether a clinical study clears NEJM's bar — practice-changing clinical impact, methodological rigor, and generalizability. Decides NEJM vs Lancet/JAMA vs a specialty journal.

Generate comprehensive clinical reports including case reports (CARE guidelines), diagnostic reports, clinical trial reports (ICH-E3, SAE, CSR), and patient documentation (SOAP, H&P, discharge summaries) with templates, regulatory compliance, and validation tools.

必须在用户需要医学报告解读时使用。包括：用户上传体检报告、检验报告、检查单、化验单、血常规/尿常规/生化/肝肾功能/血脂血糖等检验检查图片、照片、截图、PDF、文档、表格或文件；用户只发报告图片/附件且没有文字说明；用户说“帮我看看”“看下这个报告”“这个结果正常吗”“有什么问题”“报告怎么解读”；用户表达体检报告解读、医院报告解读、影像/超声/CT/MRI/内镜/病理报告解读等需求。用于梳理报告内容，解释异常指标和检查发现，识别需要关注的风险信号，并给出就医沟通、复查随访、观察监测和生活方式管理建议。

Evidence-based health research using tiered trusted sources with GRADE-inspired evidence ratings. Integrates Apple Health data for personalized context. Use when user asks health, nutrition, exercise, sleep, or wellness questions.

Use when scoping a project and before any writing, to stress-test whether a study clears The Lancet's bar — clinically or public-health important, globally relevant, and likely to change practice or policy, often with an equity lens. Decides The Lancet vs a Lancet family title vs another general medical journal.

Draft an internal legal research memo for the supervising attorney with verified authority and flagged open questions.

Generate professional clinical decision support documents for pharmaceutical and clinical research, including biomarker-stratified cohort analyses and evidence-based treatment recommendation reports with GRADE grading, statistical analysis, and publication-ready LaTeX/PDF output.

Design prospective clinical studies by selecting and classifying endpoints, estimating sample size and power for two-arm designs, and scoring study plans for feasibility with phase-gate decisions.

NIH grant research skill for clinical researchers. Grill-me intake (research idea + career stage + preliminary data + environment + submission posture + known institute targets) locks down the funding strategy before any search runs. Runs a 5-facet Consensus positioning analysis (with draft Significance/Innovation language), maps the research to the right NIH institutes and study sections via RePORTER, finds NOSIs and funded overlap, and produces an editable Word document (.docx) with budget/scope-aware mechanism recommendations, submission timelines, and a mandatory program officer recommendation. Use when the user asks about research funding or makes any grant-related request (e.g., 'grants for [topic]', 'find grants for my research idea', 'what grants match my research', 'help me find NIH funding', 'grant opportunities for my research'). NIH-only scope — non-NIH funders (PCORI, DOD CDMRP, VA, foundations) are out of scope and flagged at intake.

Query the ClinPGx API for pharmacogenomic gene-drug data, clinical annotations, CPIC guidelines, and FDA drug labels.

Query NCBI ClinVar via the E-utilities API or FTP for the clinical significance (pathogenicity) of human germline genetic variants, searching by gene, variant, condition, or genomic position and interpreting ACMG/AMP classifications and review-status star ratings. Use when assessing whether a variant is pathogenic, likely pathogenic, VUS, likely benign, or benign, resolving conflicting interpretations, or annotating a VCF with ClinVar clinical significance. For population allele frequencies by ancestry use alterlab-gnomad; for somatic cancer mutation frequencies use alterlab-cosmic. Part of the AlterLab Academic Skills suite.

Create patient intake forms with history and screening. TRIGGERS - Use when user needs help with intake-form related tasks.

Guides HIPAA-specific healthcare privacy and security work, routing to implementation and review skills with decision gates and guardrails.

Queries the ClinPGx REST API for pharmacogenomic gene-drug data, clinical annotations, CPIC guidelines, and FDA drug labels, generating markdown reports with CSV tables.

Produce a concise matter status update for the supervising attorney or case rounds, separating settled facts from open questions.

针对医疗隐私和安全工作的HIPAA特定入口点。当任务明确围绕HIPAA、PHI处理、受保实体、BAA、违规态势或美国医疗合规要求时使用。

Save the current diagnosis state to disk for cross-session recall, including conclusions, rejected directions, and next steps.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores, drug sensitivity data, and gene effect profiles to identify cancer-specific vulnerabilities, synthetic lethal interactions, and validate oncology drug targets.

从OCR识别后的医疗票据文本中提取日期、医生姓名、病人姓名、诊断和总消费，并进行文本矫正，输出JSON格式。

We need to output a SKILL.md file with the specified format.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.

Access ClinPGx pharmacogenomics data (the successor to PharmGKB) to query gene-drug interactions, CPIC/DPWG dosing guidelines, drug labels, and pharmacogene records. Use when interpreting pharmacogenes (CYP2D6, CYP2C19, TPMT, DPYD, SLCO1B1), looking up genotype-guided drug dosing, checking PGx drug-safety associations (e.g. HLA-B*57:01 and abacavir), or supporting precision medicine and clinical pharmacogenomics decisions. For star-allele definitions/frequencies see PharmVar; for germline/somatic variant pathogenicity see alterlab-clinvar. Part of the AlterLab Academic Skills suite.

`analysis-agent`/`task-agent`/`review-agent`: use when symptoms, logs, metrics, regressions, or incidents need cause analysis; skip when no diagnosis decision exists.

Write HIPAA privacy notices and acknowledgments. TRIGGERS - Use when user needs help with hipaa-notice related tasks.

Draft a legal document — a pleading, motion, brief section, or contract clause — with verified citations, flagged assumptions, and mandatory supervisor review before filing.

Guides comorbidity-stratified selection of initial and further glucose-lowering medicines for adults with type 2 diabetes using the NICE NG28 (2026) framework, covering six clinical profiles: no relevant comorbidity, heart failure, atherosclerotic cardiovascular disease, early onset, obesity, chronic kidney disease, and frailty.

Query the Cancer Dependency Map (DepMap) for CRISPR gene dependency scores, drug sensitivity data, and gene effect profiles to identify cancer-specific vulnerabilities, synthetic lethal interactions, and validate oncology drug targets.

Explains biomedical concepts, vital signs, biological signals, medical device classifications, and healthcare data standards for technical teams.

Frame causal questions and estimate treatment effects with assumption checks. Use when: (1) policy impact analysis, (2) A/B interpretation beyond correlation, (3) confounding diagnostics. NOT for: medical/legal conclusions without experts.

NIH grant research skill for clinical researchers. Grill-me intake (research idea + career stage + preliminary data + environment + submission posture + known institute targets) locks down the funding strategy before any search runs. Runs a 5-face...

Create patient intake forms with history and screening. TRIGGERS - Use when user needs help with intake-form related tasks.

Write HIPAA privacy notices and acknowledgments. TRIGGERS - Use when user needs help with hipaa-notice related tasks.

Use to design or audit the support contribution to a customer health score, so the score predicts something instead of averaging weakly-related signals into a colour. Trigger for "build a customer health score", "add support signal to health scoring", "our health scores don't predict churn", red/amber/green account scoring, or a health score nobody trusts.

Use when deciding which nejm-* sub-skill to invoke next, or when sequencing a clinical manuscript from significance test through response to reviewers for The New England Journal of Medicine. Routes — it does not replace — the specialized skills.

Applied Botany Analysis Skill