Results for “side-effects”

Titrates GH replacement dose to keep IGF-1 below the upper limit of normal and reduces dose when side effects appear. Use when monitoring GH replacement therapy; triggers include patient on GH replacement needing dose adjustment.

Use when making changes to existing systems to ensure those changes don't break existing functionality. This skill provides procedures for identifying at-risk areas, adding regression tests, and validating changes don't cause unintended side effects.

Manage Heroku add-on resources and attachments safely. Use when the agent needs to create, inspect, plan, attach, detach, upgrade, wait on, open, or destroy Heroku add-ons, or reason about attachment aliases, shared resources, config-var side effects, and add-on lifecycle guardrails.

Implement signal-based reactive state management in Angular v20+. Use for creating reactive state with signal(), derived state with computed(), dependent state with linkedSignal(), and side effects with effect(). Triggers on state management questions, converting from BehaviorSubject/Observable patterns to signals, or implementing reactive data flows.

Advises against testosterone therapy in men with biochemical recurrence after prostate cancer treatment due to very limited data and potential risk of progression. Consider when a patient has a rising PSA after definitive therapy and the clinician evaluates testosterone for hypogonadism, questioning whether TTh is safe in BCR.

Bidirectional conversion between Clojure and Elm. Use when migrating projects between these languages in either direction. Extends meta-convert-dev with Clojure↔Elm specific patterns. Use when migrating Clojure projects to Elm, translating functional patterns from JVM to browser, or building type-safe frontends from Clojure logic. Extends meta-convert-dev with Clojure-to-Elm specific patterns for handling dynamic-to-static typing, REPL-driven to TEA architecture, and side effects to managed effects.

Initiates a 6‑month trial of DHEA replacement in women with primary adrenal insufficiency (PAI) who have persistent low libido, depressive symptoms, or low energy despite otherwise optimized glucocorticoid and mineralocorticoid therapy. If the patient does not report a sustained beneficial effect after 6 months, discontinue DHEA.

Identifies common React useEffect anti-patterns and provides corrected implementations using derived state, event handlers, and cleanup functions.

Think through the consequences of consequences — not just what happens immediately, but what happens next, and next after that, across time. Load when a decision looks obviously good or obviously bad on initial read, when the user is optimising for a short-term outcome that might create a long-term problem, when unintended consequences are a concern, or when deep-thinking diagnoses a second-order frame. Triggers on "what are the downstream effects", "what happens after that", "unintended consequences", "think ahead on this", "long-term vs short-term", or "what comes after that". Based on Howard Marks second-level thinking and Farnam Street mental models. Most powerful for decisions with delayed consequences or systemic effects.

Guides choice among spironolactone, eplerenone, and esaxerenone for primary aldosteronism based on comparative efficacy, safety, and patient-specific factors. Triggers include when initiating MRA therapy and asking 'Which MRA should I prescribe?' or considering switching agents due to adverse effects, cost, or need for potassium supplementation.

Meta-skill codifying the no-wakeup-polling pattern. Describes the ScheduleWakeup anti-pattern, the fix (--auto merge + detached watcher), and when to still use wakeups. Reduces handoff spam by 80%.

Structure a decision into steelmanned, impact-weighted pros and cons - irreversible consequences flagged, the decisive unknown named, and a clear recommendation you can reject.

Write React hooks with clean effect boundaries and measured memoization. Use when working with `useEffect`, custom hooks, refs, transitions, or hook dependency problems in React.

Determines whether to recommend unilateral laparoscopic adrenalectomy or medical therapy with a mineralocorticoid receptor antagonist for patients with confirmed unilateral PA (aldosterone-producing adenoma or unilateral adrenal hyperplasia). Triggered when discussing treatment options after confirming unilateral PA in a hypertensive patient with hypokalemia or resistant hypertension.

Recommends mineralocorticoid receptor antagonists for all primary aldosteronism patients to prevent target organ damage, irrespective of blood pressure control or serum potassium levels. Triggered when a clinician encounters a PA patient with well‑controlled BP and normal K and wonders, 'Do I still need to treat with MRA?' or considers stopping therapy.

Selects spironolactone as first-line mineralocorticoid receptor antagonist for bilateral primary aldosteronism, with eplerenone as an alternative when spironolactone–related adverse effects are problematic. Trigger phrases include 'confirmed bilateral PA on AVS', 'idiopathic adrenal hyperplasia', 'bilateral adrenal hyperplasia', 'glucocorticoid-remediable aldosteronism', and 'initiating medical therapy for bilateral adrenal disease'.

Clinicians educate adrenal insufficiency patients taking nondexamethasone glucocorticoids who initiate enzyme-inducing antiepileptic drugs about early signs of adrenal insufficiency. Trigger when an AI patient on nondexamethasone GC starts an enzyme-inducing AED such as phenytoin, carbamazepine, or oxcarbazepine.

Analisa os efeitos da revelia (CPC 344-346) e suas excecoes (345), tanto quando o cliente e o revel quanto quando a parte contraria e revel. Cobre a presuncao de veracidade dos fatos (344), as quatro hipoteses em que ela NAO opera (345 — litisconsorte contestante, direito indisponivel, falta de instrumento que a lei repute indispensavel, fatos inverossimeis/contraditorios com a prova), a fluencia de prazos sem intimacao (346) e a possibilidade de o revel ingressar e produzir prova. Use quando o operador disser revelia, reu revel, parte nao contestou, efeitos da revelia, presuncao de veracidade, ou meu cliente perdeu o prazo de defesa.

Use this skill when interpreting a drug test result that comes back as 'diluted negative,' 'diluted positive,' 'refusal,' or 'adulterated.' Covers what constitutes a refusal vs. retest vs. confirmed positive.

Fix PPO training early-stop issues. Trigger when: (1) impossible drawdown values (>100%), (2) training stops too early, (3) need adaptive recovery instead of hard stop.

Use to audit how payment disputes, chargebacks and unrecognised-transaction claims are handled against scheme deadlines and evidence standards. Trigger for "audit our dispute handling", "chargeback quality review", "are we meeting scheme deadlines", unrecognised transaction claims, provisional credit decisions, or a customer complaining their dispute was rejected unfairly.

Use this skill when the user asks about FCRA adverse action procedures — what to do when a background check (MVR, criminal, drug test) returns information that may lead to denying employment or terminating a CDL driver. Covers the 5-business-day pre-adverse-action notice, FCRA Summary of Rights, final adverse action notice, state-specific add-ons (CA, NY, etc.), and how to handle disputes. Cite 15 USC § 1681 (FCRA) and 49 CFR 391.

This skill guides clinicians in sharing decision‑making when selecting an antiepileptic drug (AED) by providing quantitative estimates of each drug’s expected weight effect. It is triggered when a clinician asks how to discuss weight‑change risks when choosing an AED or what information to provide on weight effects of specific agents such as valproate versus lamotrigine.

Econometrics skill for Synthetic Control Method (SCM). Activates when the user asks about: "synthetic control", "SCM", "synthetic counterfactual", "donor pool", "placebo test", "in-space placebo", "in-time placebo", "MSPE ratio", "Abadie Diamond Hainmueller", "augmented synthetic control", "penalized SCM", "synthetic DID", "合成控制", "合成控制法", "捐助池", "安慰剂检验", "合成反事实", "合成DID", "政策评估"

Electric neon glow effects with high-contrast color pairings for bold, attention-grabbing interfaces.

AI驱动的综合健康分析系统，整合多维度健康数据、识别异常模式、预测健康风险、提供个性化建议。支持智能问答和AI健康报告生成。

Bedside prescribing reference for Bemdec (bempedoic acid / NEXLETOL) — indication check, dose, statin co-prescribing safety caps, monitoring plan, warnings for hyperuricemia and tendon rupture, and special population guidance. Use when a clinician asks "can I start bempedoic acid", "Bemdec indication", "is bempedoic acid safe with my statin", "patient on Nexletol has joint pain or high uric acid", "bempedoic acid in CKD or liver disease or pregnancy", or any prescribing or monitoring question about bempedoic acid.

Burn HUD

Recommends weight‑losing and weight‑neutral medications as first‑ and second‑line agents for managing overweight/obese patients with type 2 diabetes. Triggers include when a clinician asks, 'Which diabetes medications will not worsen weight in this obese patient?' or 'Should I avoid sulfonylureas in this patient with T2DM and obesity due to weight gain risk?'

In patients with primary aldosteronism receiving mineralocorticoid receptor antagonist therapy, the guideline recommends titrating the MRA dose upward to raise renin when blood pressure remains uncontrolled and renin is suppressed. Consider this step when hypertension is not at goal despite MRA therapy and plasma renin activity (or direct renin concentration) is low.