Results for “tumor-normal”

Advises against testosterone therapy in men with biochemical recurrence after prostate cancer treatment due to very limited data and potential risk of progression. Consider when a patient has a rising PSA after definitive therapy and the clinician evaluates testosterone for hypogonadism, questioning whether TTh is safe in BCR.

This skill recommends performing an imaging study to assess tumor size, appearance, and parasellar extent once biochemical diagnosis of acromegaly is confirmed. Trigger when IGF-1 is elevated and GH fails to suppress to <0.4 µg/L during an oral glucose tolerance test.

Manages suspected mild central hypothyroidism in patients with pituitary disease and low-normal free thyroxine (fT4). Initiates levothyroxine (L-T4) when suggestive symptoms are present or when serial fT4 shows a decrease of 20% or more.

Automates ingestion, normalization, deduplication, and distribution of threat intelligence feeds from STIX/TAXII, open-source, and commercial sources into SIEM platforms for real-time IOC matching and alerting.

Ingests, normalizes, and enriches structured and unstructured threat intelligence feeds into STIX 2.1 format, evaluating feed quality and deduplicating indicators for distribution to SIEM, firewall, and EDR platforms.

Identifies patients with normokalemia and no adrenal tumors on CT who likely have bilateral PA and may proceed directly to medical therapy without AVS. Triggers include when a clinician notes normokalemia and clean adrenal CT and asks 'Is AVS necessary if I suspect bilateral disease?'

Identifies patients with adrenal tumors on CT who should undergo dexamethasone suppression test to evaluate for autonomous cortisol co-secretion. Triggers include when a clinician finds an adrenal tumor on CT and asks 'Should I test for cortisol co-secretion?' or is planning AVS for a tumor >3.0 cm.

Avoid specific tests for TSHD diagnosis

Generates synthetic body MRI volumes using NVIDIA's NV-Generate-CTMR rflow-mr model. Wraps the upstream diffusion inference pipeline with config staging, output validation, and NIfTI volume summarization.

Generates synthetic brain MRI volumes using NVIDIA's NV-Generate-CTMR workflow, with configurable modality and random seed.

Fine-tune Cosmos Reason video QA models using supervised fine-tuning with FSDP parallelism, including dataset preparation, spec construction, and AutoML support.

Trains, evaluates, and runs inference for Mask Auto-Label (MAL) weakly-supervised segmentation models using ViT-MAE backbones with minimal point or box annotations.

Audits codebases, pages, or documents for AI-generated design and copy tells, then proposes surgical fixes for user approval.

Select, pair, and implement typefaces for web projects with guidance on readability, CSS implementation, and performance optimization.

Monitors euthyroid adults with growth hormone deficiency (GHD) who are initiating GH replacement therapy for the development of central hypothyroidism (CH). Initiates levothyroxine (L-T4) if free thyroxine (fT4) falls below the laboratory reference range; triggers include GHD patient starting GH replacement.

Recommends weight‑losing and weight‑neutral medications as first‑ and second‑line agents for managing overweight/obese patients with type 2 diabetes. Triggers include when a clinician asks, 'Which diabetes medications will not worsen weight in this obese patient?' or 'Should I avoid sulfonylureas in this patient with T2DM and obesity due to weight gain risk?'

Ranks weekly token unlocks by Absorption Ratio (unlock value / 7d avg volume) instead of supply percentage, with per-event cliff vs linear classification, recipient category, and a one-line market read.

Convert single-channel TIF directories to pyramidal OME-TIFF with SubIFDs

Renders text or images as ASCII art for terminal-friendly output, including banners, frames, QR codes, and weather.

Creates modular typography scales with size, weight, and line-height relationships for consistent digital interfaces.

Diagnosing and fixing bimodal matching score distributions in MaxFuse

Build and train graph neural networks for drug discovery, protein modeling, and molecular science using PyTorch-native tools.

Inverse ETF Proxy for Crypto Shorts

Use when the user explicitly enters TURBO, mode TURBO, enable TURBO, or TURBO for this task, and Codex should optimize for maximum quality without normal token-cost restraint.

Debugging constant Markov regime features in RL observations - when HMM probabilities show uniform values instead of dynamic regime estimates

Detects unusual options activity and classifies smart money signals to help follow institutional positioning, including volume/OI ratio spikes, block trades, sweep orders, and net premium flow.

Generates ultra-minimalist, editorial-style web interfaces with warm monochrome palettes, typographic contrast, bento-grid layouts, and muted pastel accents, rejecting generic SaaS design trends.

Scale alignment for RNA-protein cross-modal integration - BOTH modalities must be z-scored

Perform digital rectal examination (DRE) in all men before initiating testosterone therapy to exclude prostate abnormalities or support suspicion of hypogonadism when prostate volume is reduced. Triggered when a clinician considers starting testosterone and questions whether a prostate exam is needed first or whether to check the prostate before prescribing TTh.

Selects the right Gemma model for a task, recommends deployment tooling (Gradio, Transformers.js, Vertex AI, MLX), and applies optimizations like MTP and QAT.

Humanize LLM output so it reads like a careful human wrote it. Subtracts AI-isms (sycophancy, tricolons, em-dash overuse, "delve"/"tapestry"/"testament", hedging stacks, tidy five-paragraph shapes), engineers burstiness and calibrated uncertainty, and preserves technical accuracy. Supports intensity levels: subtle, balanced (default), full, voice-match, anti-detector. Use when user says "humanize this", "make this sound human", "de-slop this", "rewrite without AI tone", "match my voice", "less robotic", or invokes /unslop. Also auto-triggers when text-quality is requested.

Authorized reverse engineering of custom binary protocols, Protobuf/gRPC, WebSocket frames, and PCAP-driven protocol recovery with structured workflow and tooling.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores, drug sensitivity data, and gene effect profiles to identify cancer-specific vulnerabilities, synthetic lethal interactions, and validate oncology drug targets.

Processes STIX 2.1 threat intelligence bundles from TAXII 2.1 servers, normalizing objects into platform-native schemas and routing them to consuming systems.

Exploit path normalization discrepancies between CDN caching layers and origin servers to cache and retrieve authenticated content.