Results for “variant-query”

60 skills

Query the 1000 Genomes Project dataset at the individual participant level to find variants, carriers, and relatedness information.

30.2k · bundle

Store, query, and export genomic variant data (VCF/BCF) using TileDB's sparse array technology for scalable population genomics workflows.

Alterlab Gnomad

Query gnomAD (Genome Aggregation Database) for population allele frequencies and gene constraint scores (pLI, LOEUF) reflecting loss-of-function intolerance. Use when checking how common a variant is across populations, filtering rare-disease candidate variants, assessing variant pathogenicity, or identifying loss-of-function intolerant genes. Part of the AlterLab Academic Skills suite.

Alterlab Ensembl

Query the Ensembl genome database REST API across 250+ species for gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, and Variant Effect Predictor (VEP) annotations. Use when mapping gene IDs or coordinates, fetching genomic sequence, finding orthologs across species, or predicting variant consequences for genomic research. Part of the AlterLab Academic Skills suite.

Gnomad Database

Query gnomAD for population allele frequencies, constraint metrics, and loss-of-function intolerance. Use when interpreting variants, filtering common alleles, or prioritizing genes in rare disease workflows.

Query the GTEx (Genotype-Tissue Expression) portal v2 REST API for tissue-specific gene expression (median TPM across 54 human tissues), expression QTLs (eQTLs), and splicing QTLs (sQTLs). Use when checking which tissues express a gene, finding which gene a non-coding/GWAS variant regulates via eQTLs, or interpreting variant regulatory effects across tissues. NOT for curated trait-variant associations (use alterlab-gwas), population allele frequencies or variant constraint (use alterlab-gnomad), or gene/transcript structure and ID mapping (use alterlab-ensembl). Part of the AlterLab Academic Skills suite.

More results

Alterlab Clinvar

Query NCBI ClinVar via the E-utilities API or FTP for the clinical significance (pathogenicity) of human germline genetic variants, searching by gene, variant, condition, or genomic position and interpreting ACMG/AMP classifications and review-status star ratings. Use when assessing whether a variant is pathogenic, likely pathogenic, VUS, likely benign, or benign, resolving conflicting interpretations, or annotating a VCF with ClinVar clinical significance. For population allele frequencies by ancestry use alterlab-gnomad; for somatic cancer mutation frequencies use alterlab-cosmic. Part of the AlterLab Academic Skills suite.

Variant Analysis

Find similar vulnerabilities and bugs across codebases using pattern-based analysis after identifying an initial issue.

Analyzing Malware Family Relationships With Malpedia

Query the Malpedia API to research malware family relationships, track variant evolution, link families to threat actors, and integrate YARA rules for detection across malware lineages.

24.6k · bundle

Deploys Weaviate vector database with hybrid search, modules, and GraphQL API.

brycewang-stanford

VS-Enhanced Research Question Refiner - Prevents Mode Collapse and derives differentiated research questions Enhanced VS 3-Phase process: Modal question avoidance, alternatives presentation, differentiated RQ recommendation Use when: refining research ideas, formulating research questions, clarifying scope Triggers: research question, 연구 질문, PICO, SPIDER, research idea

A checkbox component for binary and multiple selections with support for groups, indeterminate state, custom values, and grid layouts

Scan for viral app opportunities from trends, gaps, and user pain points

Qdrant Search Strategies

Guides selection of Qdrant search strategies including hybrid search, reranking, relevance feedback, MMR, and discovery APIs to improve retrieval quality.

Qdrant Model Migration

Guides embedding model migration in Qdrant without downtime, covering alias swap, side-by-side, and hybrid search strategies.

Answers questions using a structured wiki knowledge base, returning cited synthesis with wikilinks, counter-arguments, and knowledge gaps.

Design shotgun: generate multiple AI design variants, open a comparison board, collect structured feedback, and iterate. (gstack)

Quick feasibility and novelty check — go/no-go decision for this week's build

Qdrant Vector Search

High-performance vector similarity search engine for RAG and semantic search. Use when building production RAG systems requiring fast nearest neighbor search, hybrid search with filtering, or scalable vector storage with Rust-powered performance.

Multi Source Search

Multi-source search for agents across web, scholar, Tavily, and Perplexity Sonar endpoints. Use when you need structured retrieval, citation-backed answers, or broad research coverage from one AIsa API key.

Generate rights-cleared product photography variants for paid ads from an authorized source image and brand profile.

Qdrant Vector Search

High-performance vector similarity search engine for RAG and semantic search. Use when building production RAG systems requiring fast nearest neighbor search, hybrid search with filtering, or scalable vector storage with Rust-powered performance.

汇总某个经管实证变量在文献中的测算口径、数据来源、模型角色和项目可用性

Throwaway HTML mockups: 2-3 design variants to compare.

aniruddhaadak80

Qdrant Vector Search

High-performance vector similarity search engine for RAG and semantic search. Use when building production RAG systems requiring fast nearest neighbor search, hybrid search with filtering, or scalable vector storage with Rust-powered performance.

Qdrant Vector Search

Builds production RAG and semantic search systems with Qdrant, covering collection setup, vector indexing, filtered and hybrid search, and integration with LangChain and LlamaIndex.

Vector-powered CLI for semantic file search with a Claude/Codex skill

Enables semantic file search across a codebase using a vector-powered CLI, with integration for Claude and Codex agents.

API Versioning Strategy

Versioning exists because you cannot deploy your clients.

Local hybrid search for markdown notes and docs. Use when searching notes, finding related content, or retrieving documents from indexed collections.

Query the bundled research knowledge graph for methodology guidance. Routes questions through a 3-tier knowledge base — WHY (research claims), HOW (guidance docs), WHAT IT LOOKS LIKE (domain examples) — plus structured reference documents. Returns research-backed answers grounded in specific claims with practical application to the user's system. Triggers on "/ask", "/ask [question]", "why does my system...", "how should I...".

To Questionnaire

Turn a decision you can't fully answer into a questionnaire for someone else to fill in.

对 wiki 提问，综合检索相关页面后回答，好的回答可 crystallize 回 wiki

通用多轮迭代改进：对任意研究制品反复调用 /review → 解析反馈 → 修复 → 更新 wiki，直到达标

Provides guidance and patterns for using a vector-powered CLI for semantic file search with Claude/Codex skills.

brycewang-stanford

Agent C3 - Mixed Methods Design Consultant Comprehensive mixed methods research design specialist covering sequential, concurrent, embedded, and multiphase designs with Morse notation. Core Capabilities: - Sequential Explanatory (QUAN → qual): Explain quantitative results - Sequential Exploratory (QUAL → quan): Develop instruments - Convergent Parallel (QUAN + QUAL): Comprehensive understanding - Embedded (QUAN(qual)): Secondary strand addresses different question - Multiphase: Long-term projects with iterative phases - Morse notation interpretation and recommendation