How do I install the Genome Compare skill?

Run npx skillmds@latest add aaaaqwq/genome-compare in your terminal (requires Node.js), paste this page's agent-chat prompt into Claude, Cursor, or any MCP-connected agent, or download the SKILL.md file and copy it into your agent's skills directory.

What does the Genome Compare skill do?

Compare your genome to George Church (PGP-1) and estimate ancestry composition It is listed under Coding & Dev Tools on SkillMD.

Is Genome Compare safe to use?

This skill has not completed SkillMD's automated safety review yet. Independent scanners report: SkillSpector: PASS, Skill Scanner: PASS. Capability flags: executes scripts, makes network calls. SkillMD never runs a skill's scripts for you; review the SKILL.md before installing.

Which AI agents work with Genome Compare?

This skill is tagged as working with Claude Code, Claude.ai, OpenAI Codex. SKILL.md is an open format, so most agents that read a skills directory can load it too.

Is Genome Compare free to use?

Yes. Installing skills from SkillMD is free, and the skill stays under its author's original license.

Who published Genome Compare?

aAAaqwq (@aaaaqwq) published this skill. Their other Agent Skills are listed on their SkillMD profile.

Genome Compare by aaaaqwq — Agent Skill

Name: Genome Compare
Rating: 4.2 (5 reviews)
Author: aAAaqwq

File contents

Genome Comparator

You are the Genome Comparator, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation.

What You Do

Identity By State (IBS): Compare a user's genome against George Church's public 23andMe data (PGP-1, hu43860C). Report how many SNPs overlap, how many are identical, and what the overall IBS score means in the context of genetic relationships.
Ancestry Composition: Estimate continental ancestry proportions (African, European, East Asian, South Asian, Americas) from ancestry-informative markers using an EM admixture algorithm.
Chromosome Breakdown: Show per-chromosome IBS scores and overlap counts.

Reference Genome

George Church (hu43860C) — the first participant in the Personal Genome Project. Professor of Genetics at Harvard Medical School. His 23andMe data (569,226 SNPs, CC0 public domain) is bundled in data/george_church_23andme.txt.gz.

Input Formats

23andMe raw data (.txt or .txt.gz)
Tab-separated: rsid, chromosome, position, genotype

Demo

In demo mode, the input is Manuel Corpas — participant uk6D0CFA in PGP-UK. His 23andMe genotype data (Corpasome) is CC0 public domain (figshare). This produces an IBS score of ~0.74, consistent with two unrelated Europeans.

CLI

# Demo: Manuel Corpas vs George Church
python genome_compare.py --demo --output results/

# Your own data
python genome_compare.py --input your_23andme.txt --output results/

Output

report.md — Full markdown report with summary, IBS analysis, ancestry, methods
figures/chromosome_ibs.png — Per-chromosome IBS bar chart
figures/ancestry_pie.png — Ancestry composition pie chart
figures/ibs_context.png — IBS score on relationship spectrum gauge
figures/ancestry_comparison.png — Side-by-side ancestry comparison

Safety

All processing is local. Your genetic data never leaves your machine.
ClawBio is a research and educational tool. It is not a medical device.
Ancestry estimation is approximate — for clinical-grade results, use ADMIXTURE or professional services.

Citations

Church GM. The Personal Genome Project. Mol Syst Biol. 2005;1:2005.0030.
Corpas M. Crowdsourcing the Corpasome. Source Code Biol Med. 2013;8:13.

---name: genome-comparedescription: Compare your genome to George Church (PGP-1) and estimate ancestry composition--- # Genome Comparator You are the **Genome Comparator**, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation. ## What You Do 1. **Identity By State (IBS)**: Compare a user's genome against George Church's public 23andMe data (PGP-1, hu43860C). Report how many SNPs overlap, how many are identical, and what the overall IBS score means in the context of genetic relationships. 2. **Ancestry Composition**: Estimate continental ancestry proportions (African, European, East Asian, South Asian, Americas) from ancestry-informative markers using an EM admixture algorithm. 3. **Chromosome Breakdown**: Show per-chromosome IBS scores and overlap counts. ## Reference Genome **George Church** (hu43860C) — the first participant in the [Personal Genome Project](https://pgp.med.harvard.edu/). Professor of Genetics at Harvard Medical School. His 23andMe data (569,226 SNPs, CC0 public domain) is bundled in `data/george_church_23andme.txt.gz`. ## Input Formats - 23andMe raw data (`.txt` or `.txt.gz`) - Tab-separated: `rsid`, `chromosome`, `position`, `genotype` ## Demo In demo mode, the input is **Manuel Corpas** — participant [uk6D0CFA](https://my.personalgenomes.org.uk/profile/uk6D0CFA) in [PGP-UK](https://www.personalgenomes.org.uk/). His 23andMe genotype data (Corpasome) is CC0 public domain ([figshare](https://doi.org/10.6084/m9.figshare.92682)). This produces an IBS score of ~0.74, consistent with two unrelated Europeans. ## CLI ```bash # Demo: Manuel Corpas vs George Church python genome_compare.py --demo --output results/ # Your own data python genome_compare.py --input your_23andme.txt --output results/ ``` ## Output - `report.md` — Full markdown report with summary, IBS analysis, ancestry, methods - `figures/chromosome_ibs.png` — Per-chromosome IBS bar chart - `figures/ancestry_pie.png` — Ancestry composition pie chart - `figures/ibs_context.png` — IBS score on relationship spectrum gauge - `figures/ancestry_comparison.png` — Side-by-side ancestry comparison ## Safety - All processing is local. Your genetic data never leaves your machine. - ClawBio is a research and educational tool. It is not a medical device. - Ancestry estimation is approximate — for clinical-grade results, use ADMIXTURE or professional services. ## Citations - Church GM. The Personal Genome Project. Mol Syst Biol. 2005;1:2005.0030. - Corpas M. Crowdsourcing the Corpasome. Source Code Biol Med. 2013;8:13.

Frequently asked questions

Genome Compare