Ranking: Execute TrialGPT ranking script to score each trial and emit explanations.
Handoff: Export ranked list + structured criteria for trial-eligibility-agent.
Guardrails
Refresh ClinicalTrials.gov metadata regularly to avoid stale trials.
Label scores as AI-generated suggestions pending clinician validation.
Retain prompt/config metadata for audit trails.
References
Detailed usage instructions and repo layout live in README.md.
Coordinate with Skills/Clinical/Trial_Eligibility_Agent for criterion-level review.
1---2name: trialgpt-matching3description: <!--4---5<!--6# COPYRIGHT NOTICE7# This file is part of the "Universal Biomedical Skills" project.8# Copyright (c) 2026 MD BABU MIA, PhD <md.babu.mia@mssm.edu>9# All Rights Reserved.10#11# This code is proprietary and confidential.12# Unauthorized copying of this file, via any medium is strictly prohibited.13#14# Provenance: Authenticated by MD BABU MIA1516-->1718---19name: trialgpt-matching20description: Trial shortlist21keywords:22 - retrieval23 - ranking24 - ClinicalTrials25 - patient-profile26measurable_outcome: Produce ≥5 ranked trials (when available) with rationale + missing-data notes within 3 minutes of receiving a patient query.27license: MIT28metadata:29 author: TrialGPT Team30 version: "1.0.0"31compatibility:32 - system: Python 3.9+33allowed-tools:34 - run_shell_command35 - read_file36---3738# TrialGPT Matching3940Run the locally checked-out TrialGPT pipeline to retrieve, rank, and explain candidate trials for a patient before deeper eligibility review.4142## Inputs43- Patient summary (structured JSON or free text) with condition keywords.44- Optional filters: geography, phase, intervention, biomarker.45- Up-to-date ClinicalTrials.gov dump or API access.4647## Outputs48- Ranked trial table with NCT ID, title, score, and short justification.49- Parsed inclusion/exclusion text ready for downstream eligibility agents.50- Missing data checklist (e.g., "ECOG not provided").5152## Workflow531. **Setup:** `cd repo && pip install -r requirements.txt` (or reuse env).542. **Trial retrieval:** Run TrialGPT retriever to pull candidate trials for the indication.553. **Criteria parsing:** Convert eligibility blocks to structured criteria JSON.564. **Patient profiling:** Summarize patient facts (labs, prior therapies, biomarkers).575. **Ranking:** Execute TrialGPT ranking script to score each trial and emit explanations.586. **Handoff:** Export ranked list + structured criteria for `trial-eligibility-agent`.5960## Guardrails61- Refresh ClinicalTrials.gov metadata regularly to avoid stale trials.62- Label scores as AI-generated suggestions pending clinician validation.63- Retain prompt/config metadata for audit trails.6465## References66- Detailed usage instructions and repo layout live in `README.md`.67- Coordinate with `Skills/Clinical/Trial_Eligibility_Agent` for criterion-level review.686970<!-- AUTHOR_SIGNATURE: 9a7f3c2e-MD-BABU-MIA-2026-MSSM-SECURE -->
Run npx skillmds@latest add biotender-max/trialgpt-matching in your terminal (requires Node.js), paste this page's agent-chat prompt into Claude, Cursor, or any MCP-connected agent, or download the SKILL.md file and copy it into your agent's skills directory.
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