Experiment Lab

Experiment Lab Skill

This skill governs MedrixFlow's experiment workflow. It does not replace execution tools. It tells the agent when to use the structured experiment pipeline and how to keep results defensible.

Use This Skill For

• CS/AI experiments on local structured data
• Regression, classification, clustering, PCA/UMAP, and simple ablation tasks
• Empirical social-science or public-health data analysis when paired with /mnt/skills/public/empirical-research-methods/SKILL.md
• Bioinformatics workflows on local expression data, metadata tables, h5ad, or 10x matrix bundles
• QC, differential expression, enrichment attempts, marker-gene summaries
• Requests for manuscript-grade figures or experiment bundles for a report

Core Rules

• Do not invent datasets, metrics, plots, baselines, enrichments, or scientific conclusions.
• Exception: when thread context enables Synthetic Experiment Mode, personal experiment data may be simulated from explicit assumptions to complete the manuscript workflow. Public literature, DOI, baseline, leaderboard, benchmark, license, and dataset-version facts must still be real and verifiable.
• For benchmark-driven work, use dataset_benchmark_discovery first to map candidate datasets, leaderboards, metrics, access limits, and baseline/SOTA hints.
• If the task requires actual experimental output, prefer the experiment_lab tool instead of ad hoc reasoning.
• Ask for missing inputs before running a workflow when the absence would invalidate the result:
  • no dataset
  • no target column for supervised CS/AI work
  • no metadata/group labels for requested differential analysis
• Keep literature evidence separate from experimental evidence. Use academic_research only for related work or method framing.
• Keep candidate benchmark evidence separate from executed experiment evidence. A dataset map can justify a plan, but only experiment_lab or attached result files can support manuscript result claims.
• Default to Python-first execution. Do not ask the user to choose Python or R unless they explicitly request R output.
• For empirical methods such as DID, IV, RDD, PSM/IPW, synthetic control, DML, causal forest, target-trial emulation, TMLE, survival, Table 1, event study, robustness, heterogeneity, or mechanism analysis, first load /mnt/skills/public/empirical-research-methods/SKILL.md and follow its identification gates.

Iterative Experiment Loop

For code-tuning, model-training, ablation, or autonomous experiment requests, use an autoresearch-style loop when the environment supports it:

• Establish a baseline before changing code or hyperparameters.
• Define one primary metric and direction up front, such as lower validation loss or higher AUROC.
• Keep the evaluation harness, dataset split, and comparison budget fixed unless the user explicitly asks to change them.
• Change one coherent idea per trial so the result remains attributable.
• Record each trial with commit or run id, metric, memory/runtime if available, status (keep, discard, or crash), and a short description.
• Keep a change only when it improves the primary metric or clearly simplifies the system without hurting the metric.
• Treat crashes, OOMs, timeout, missing metrics, or incompatible dependencies as failed trials; summarize the failure and move on.
• Do not start an indefinite or overnight loop unless the user explicitly asks for a long-running autonomous run.

CS/AI Routing

• Supervised tabular prediction: run regression or classification through experiment_lab
• Diagnostics:
  • binary classification -> confusion matrix, ROC, PR, feature importance if available
  • regression -> predicted-vs-actual, residual distribution, feature importance if available
• Unsupervised tasks:
  • clustering -> cluster projection + silhouette
  • dimensionality reduction -> PCA/UMAP embedding

Empirical Research Routing

For empirical social-science and public-health datasets, the empirical-research-methods skill defines the method contract. Use it to decide whether the requested work is descriptive, predictive, or causal, then pass method details into experiment_lab metadata:

• empirical_method: did, staggered_did, iv, rdd, psm, synthetic_control, dml, causal_forest, target_trial, tmle, survival, or regression
• estimand: ATE, ATT, LATE, CATE, event-time effect, risk difference, hazard ratio, or predictive metric
• outcome, treatment, unit_id, time, treatment_time, instrument, running_variable, cutoff, covariates, fixed_effects, cluster
• required_outputs: Table 1, main results, identification graphic, robustness, heterogeneity, mechanism, and reproducibility ledger

If the current backend cannot execute the requested causal estimator, run only the closest safe descriptive/regression workflow, record the requested method as not executed, and avoid causal claims.

Bioinformatics Routing

• Bulk expression:
  • sample QC
  • sample PCA
  • top-variable-gene heatmap
  • differential analysis when metadata allows
  • enrichment attempt when significant genes and dependencies allow
• Single-cell starter:
  • cell QC
  • PCA/UMAP embedding
  • clustering
  • marker summary
  • marker heatmap or violin plot

Expected Deliverables

When using the structured pipeline, prefer returning a concise summary plus artifacts. The artifact bundle should usually include:

• experiment_contract.json
• experiment_plan.md
• methods.md
• results.md
• metrics.json
• baseline_results.json
• ablation_results.json
• robustness_results.json
• error_analysis.md
• claim_support_matrix.json
• Synthetic Experiment Mode also requires simulated_experiment_contract.json, simulation_assumptions.json, and synthetic_results.json.
• Synthetic-mode claim maps should use supported_by_simulation, not supported_by_experiment, for simulated personal experimental outputs.
• figure_manifest.json
• figures/
• tables/

If the experiment is linked to an academic project, also retain:

• paper_ready_results.md
• evidence.json

Tool Contract

Use experiment_lab when the user needs execution, metrics, or figure generation. Pass:

• topic
• dataset_paths
• domain when clear
• analysis_type when explicit
• target_column for supervised CS/AI work
• metadata_path, sample_id_column, and group_column for bulk expression tasks when available
• linked_academic_project_id when the experiment should feed a formal report
• synthetic_data_mode=true when Synthetic Experiment Mode is enabled
• metadata with empirical method, estimand, variables, identification assumptions, and required outputs for empirical research tasks; in Synthetic Experiment Mode, include synthetic_data_mode=true and simulation assumptions when known

MATLAB Routing

Use matlab_execution only when the user explicitly needs MATLAB and command-line MATLAB is available. Generate a complete .m script, run it via batch mode, and write all figures, .mat, .csv, and logs into the provided output directory. Do not claim MATLAB GUI control; GUI automation requires a separate desktop integration outside this skill.

MATLAB results still need the same evidence discipline:

• save numeric outputs in machine-readable files
• summarize the method and parameters
• link manuscript claims to generated artifacts
• mark missing ablations or robustness checks as limitations

Final Response Pattern

• Say what analysis ran
• Report the main metrics or biological outputs
• Mention important fallbacks or skipped stages
• Point to the generated artifact bundle instead of dumping long raw output into chat