How do I install the 48_LTKB skill?

Run npx skillmds@latest add gabrielmoreira/48-ltkb in your terminal (requires Node.js), paste this page's agent-chat prompt into Claude, Cursor, or any MCP-connected agent, or download the SKILL.md file and copy it into your agent's skills directory.

Is 48_LTKB safe to use?

This skill has not completed SkillMD's automated safety review yet. Independent scanners report: SkillSpector: PASS, Skill Scanner: PASS. Capability flags: executes scripts, makes network calls. SkillMD never runs a skill's scripts for you; review the SKILL.md before installing.

Which AI agents work with 48_LTKB?

This skill is tagged as working with Claude Code, Claude.ai, OpenAI Codex. SKILL.md is an open format, so most agents that read a skills directory can load it too.

Is 48_LTKB free to use?

Yes. Installing skills from SkillMD is free, and the skill stays under its author's original license.

Who published 48_LTKB?

gabrielmoreira (@gabrielmoreira) published this skill. Their other Agent Skills are listed on their SkillMD profile.

48_LTKB by gabrielmoreira — Agent Skill

Name: 48_LTKB
Rating: 4.2 (5 reviews)
Author: gabrielmoreira

48_LTKB

Query the DILIrank/FDA Liver Toxicity Knowledge Base (LTKB). Use whenever the user asks about drug-induced liver injury (DILI) risk, hepatotoxicity classification, or wants to look up any drug (by name, LTKB ID, or DILIst ID) in the DILIrank or DILIst datasets.

gabrielmoreira Updated Sep 9, 2026 17 repo stars

File contents

LTKB Query Skill

Search FDA LTKB records (DILIrank 2.0 + DILIst) by any entity. Auto-detects type by pattern:

Input Pattern	Detected As	Searched In
`LT00040`	LTKB ID	DILIrank only
`2` (digits)	DILIst ID	DILIst only
anything else	drug name	both datasets (substring)

Datasets

DILIrank 2.0 — 1,036 FDA-approved drugs ranked by DILI concern:

vDILI-Concern	Meaning
vMOST-DILI-concern	Strong evidence of causing DILI
vLess-DILI-concern	Some evidence of causing DILI
vNo-DILI-concern	No credible evidence
vAmbiguous-DILI-concern	Conflicting/insufficient evidence

Columns: LTKBID, CompoundName, SeverityClass, LabelSection, vDILI-Concern, Comment

DILIst — 1,279 drugs classified by DILI severity:

Classification	Meaning
1	DILI-positive
0	DILI-negative

Columns: DILIST_ID, CompoundName, DILIst Classification, Routs of Administration

API

Function	Input	Returns
`load_all(rank_path, list_path)`	Excel paths	`{"dilirank": [...], "dilist": [...]}`
`search(data, entity)`	data dict + entity string	`{"entity", "type", "dilirank": [], "dilist": []}`
`search_batch(data, entities)`	data dict + list of strings	`{entity: search_result}`
`summarize(result, entity)`	search result + label	compact text
`to_json(result)`	search result	JSON string

Usage

See if __name__ == "__main__" block in 48_LTKB.py for runnable examples covering: drug name, LTKB ID, DILIst ID, batch search, and JSON output.

Data

Source: FDA LTKB — https://www.fda.gov/science-research/bioinformatics-tools/liver-toxicity-knowledge-base-ltkb
Files: Drug Induced Liver Injury Rank (DILIrank 2.0) Dataset FDA.xlsx, DILIst Supplementary Table.xlsx
Path: DATA_DIR variable in 48_LTKB.py

---name: 48-ltkbdescription: Query the DILIrank/FDA Liver Toxicity Knowledge Base (LTKB). Use whenever the user asks about drug-induced liver injury (DILI) risk, hepatotoxicity classification, or wants to look up any drug (by name, LTKB ID, or DILIst ID) in the DILIrank or DILIst datasets.--- # LTKB Query Skill Search FDA LTKB records (DILIrank 2.0 + DILIst) by any entity. Auto-detects type by pattern: | Input Pattern | Detected As | Searched In | |---|---|---| | `LT00040` | LTKB ID | DILIrank only | | `2` (digits) | DILIst ID | DILIst only | | anything else | drug name | both datasets (substring) | ## Datasets **DILIrank 2.0** — 1,036 FDA-approved drugs ranked by DILI concern: | vDILI-Concern | Meaning | |---|---| | vMOST-DILI-concern | Strong evidence of causing DILI | | vLess-DILI-concern | Some evidence of causing DILI | | vNo-DILI-concern | No credible evidence | | vAmbiguous-DILI-concern | Conflicting/insufficient evidence | Columns: `LTKBID`, `CompoundName`, `SeverityClass`, `LabelSection`, `vDILI-Concern`, `Comment` **DILIst** — 1,279 drugs classified by DILI severity: | Classification | Meaning | |---|---| | 1 | DILI-positive | | 0 | DILI-negative | Columns: `DILIST_ID`, `CompoundName`, `DILIst Classification`, `Routs of Administration` ## API | Function | Input | Returns | |---|---|---| | `load_all(rank_path, list_path)` | Excel paths | `{"dilirank": [...], "dilist": [...]}` | | `search(data, entity)` | data dict + entity string | `{"entity", "type", "dilirank": [], "dilist": []}` | | `search_batch(data, entities)` | data dict + list of strings | `{entity: search_result}` | | `summarize(result, entity)` | search result + label | compact text | | `to_json(result)` | search result | JSON string | ## Usage See `if __name__ == "__main__"` block in `48_LTKB.py` for runnable examples covering: drug name, LTKB ID, DILIst ID, batch search, and JSON output. ## Data - **Source**: FDA LTKB — <https://www.fda.gov/science-research/bioinformatics-tools/liver-toxicity-knowledge-base-ltkb> - **Files**: `Drug Induced Liver Injury Rank (DILIrank 2.0) Dataset FDA.xlsx`, `DILIst Supplementary Table.xlsx` - **Path**: `DATA_DIR` variable in `48_LTKB.py`

Frequently asked questions