GDKD-query

Query the Gene-Drug Knowledge Database (GDKD) for variant-specific gene–drug associations in oncology. Use when the user asks about cancer genomic biomarkers, drug sensitivity/resistance by gene or variant, targetable mutations, or clinical evidence for cancer therapeutics.

gabrielmoreira Updated 17 repo stars

File contents

GDKD Query Skill

Search canonical GDKD rows by drug or gene entity. Auto-detects input type by pattern:

Input Pattern Detected As Match Logic
ABL1, EGFR Gene symbol substring on gene
imatinib, erlotinib Drug name substring on drug
anything else Free text substring on drug OR gene

API

Function Input Returns
load_gdkd(path) CSV path list[dict]
search(rows, entity) single entity string list[dict]
search_batch(rows, entities) list of entity strings dict[str, list[dict]]
summarize(hits, entity) rows + label compact text
to_json(hits) rows list[dict]

Usage

See if __name__ == "__main__" block in example.py for runnable examples.

Data

  • Source: GDKD normalized full-package output
  • Paper: Dienstmann et al., Cancer Discovery 2015;5(2):118-123
  • Format: CSV
  • Columns: drug, gene, score, source
  • Path: resources_metadata/dti/GDKD/gdkd.csv (default DATA_PATH in example.py)

gabrielmoreira/agent-skills-mirror/tree/main/mirrors/repos/BioTender-max@awesome-bio-agent-skills/skills/drugclaw/gdkd commit c671e734ea

Frequently asked questions

npx skillmds@latest add gabrielmoreira/gdkd-query