NIST/SEMATECH e-Handbook of Statistical Methods (NIST HB 151)
Source: NIST/SEMATECH (US Government work, public domain) | Chapters: 8
When to use
Use this skill when you need applied frequentist statistics for engineering, metrology, or quality work, drawing from the NIST/SEMATECH e-Handbook of Statistical Methods (NIST HB 151). It is the right pack for exploratory data analysis and the four univariate assumptions (4-plot), measurement process characterization including bias/precision, calibration designs, gauge R&R, and ISO/GUM uncertainty budgets, production process characterization covering stability vs. capability, process modeling and regression (LS/WLS/NLS/LOESS), design of experiments (screening, fractional/factorial, response-surface, Taguchi), statistical process control (Shewhart/CUSUM/EWMA charts, capability indices, acceptance sampling), product/process comparisons (hypothesis tests and confidence intervals for one, two, or more groups, ANOVA, multiple comparisons), and reliability (lifetime and repair-rate models, accelerated testing, reliability growth).
Prerequisites: none, plain Markdown; no MCP server, API key, or licence tier needed at runtime.
How to Use This Skill
- Without arguments — load the Core Frameworks below: the EDA mindset, the
characterization→modeling→improvement→control→comparison→reliability arc, and the
routing rules for picking a method.
- With a statistical task — route to the right chapter and pattern. Examples:
"is my data in control?" → ch01 (4-plot); "state the uncertainty of this result" →
ch02 (GUM budget); "design an experiment to optimize yield" → ch05 (DOE);
"which control chart for small drifts?" → ch06 (CUSUM/EWMA); "compare three machines"
→ ch07 (ANOVA + multiple comparisons); "fit a life distribution" → ch08 (Weibull).
- With a chapter —
ch01 EDA · ch02 measurement/uncertainty · ch03 process
characterization · ch04 regression · ch05 DOE · ch06 SPC · ch07 comparisons ·
ch08 reliability.
Supporting files: glossary.md, patterns.md, cheatsheet.md.
Prerequisites: none — plain Markdown; no MCP server, API key, or runtime licence needed.
What this Handbook is. A practitioner's reference for engineering statistics —
measurement, process, and quality work — not a mathematical-statistics textbook. Its
through-line is the engineering scientific method: characterize a process, model it,
improve it by experiment, hold the gains with control charts, compare alternatives with
the right test, and predict how long it will last. The signature attitude (from ch01)
is look at the data before imposing a model.
Core Frameworks & Mental Models
The EDA stance — let the data reveal the model (ch01)
Classical analysis imposes a model (normality, linearity), then estimates and tests it.
Exploratory Data Analysis (EDA) holds that decision back: plot the data first and let
its structure surface. The unifying baseline is the univariate model Y = c + ε and
its four assumptions — the data have (1) fixed location, (2) fixed scale, (3) randomness
(no autocorrelation), and (4) a fixed distribution. The 4-Plot (run-sequence, lag,
histogram, normal-probability) tests all four at a glance. Pass all four ⇒ the process is
"in statistical control" and predictable. A failed panel is a diagnostic pointing at a
physical cause. Residuals are the universal diagnostic: an adequate model leaves
structureless residuals.
Characterizing a measurement process — goodness decomposed (ch02)
Treat measurements as the output of a process and ask how good they are. Goodness splits
into bias (quantitative offset from the reference/true value), short-term variability
/ precision (level-1), long-term / day-to-day variability (level-2, often larger
than precision for very precise instruments), and uncertainty. The engine is the
check standard — a database of repeated measurements on a stable surrogate — monitored
by an individuals Shewhart chart (and EWMA for small shifts). Calibration designs
are redundant least-squares intercomparison schedules (anchored by a restraint = the
known reference value) that assign values while cancelling constant left-right bias and
linear drift. Gauge R&R nested designs separate repeatability, reproducibility, and
stability. Uncertainty follows the ISO/GUM framework: every component a standard
deviation, grouped by Type A (from statistical analysis) vs. Type B (other means),
combined by root-sum-squares with sensitivity coefficients, expanded by a coverage
factor U = k·u (k≈2 ⇒ ~95%), with Welch-Satterthwaite for unknown degrees of freedom.
Characterizing a production process — stability before capability (ch03)
Frame the process as a black box (inputs / controlled factors / uncontrolled noise /
output), then expand drivers with a fishbone diagram. Distribution = location +
spread + shape. Models span the Continuous Linear Model (CLM), ANOVA, and
discrete (contingency/chi-square) forms. Two rules dominate: add variances, never
standard deviations when combining error; and establish stability before claiming
capability — Cp/Cpk on an out-of-control process are meaningless. Interpret graphically,
then confirm numerically. The most expensive mistake is skimping on planning.
Modeling a process — function plus error (ch04)
The general statistical model is y = f(x; β) + ε: a deterministic function of the factors
plus random error. Four method families build it — linear least squares, nonlinear
least squares, weighted least squares (WLS) for non-constant variance, and LOESS
for local, assumption-light smoothing. A model is used to estimate, predict, calibrate,
and optimize. Six standard assumptions (random errors, mean zero, constant variance,
known distribution, independence, correct functional form) are checked through residual
analysis — the same look-at-the-residuals discipline as EDA.
Improving by experiment — sequential DOE (ch05)
Design of Experiments varies factors together to estimate effects efficiently; its
four objective classes are comparative, screening, response-surface, and regression.
The strategy is a staircase, not one big experiment: screen many factors cheaply with
fractional factorial / Plackett-Burman designs, test curvature with center points,
foldover to de-alias, then spend three-level response-surface runs (CCD,
Box-Behnken) near the optimum. Resolution (III/IV/V) is the confounding dial; the
defining relation and generators set the aliasing. One-factor-at-a-time is a
trap — it misses interactions. Taguchi robust design (parameter design via inner/outer
arrays, then tolerance design) minimizes sensitivity to noise. Always randomize; finish with
confirmation runs.
Holding the gains — statistical process control (ch06)
SPC/SQC uses control charts to separate common-cause from special-cause variation.
Phase I builds and validates limits from history; Phase II monitors new data.
Chart families: Shewhart (X-bar & R/s, individuals) for large shifts; CUSUM (V-mask)
and EWMA (memory depth λ) for small sustained drifts; attributes charts for counts;
Hotelling's T² for correlated multivariate data. Control limits ≠ specification
limits (voice of the process vs. voice of the customer). Compare charts by Average Run
Length (ARL): sensitivity is bought with false alarms (WECO rules). Decide the response
in advance with an OCAP. Acceptance sampling (OC curve, AQL/LTPD, producer's/
consumer's risk, AOQ/AOQL) governs lot accept/reject decisions.
Comparing alternatives — the right test (ch07)
Route by how many processes: one (t/z, chi-square, exact-binomial/Wilson), two
(two-sample/paired t, F-test, two-proportion z / Fisher exact), or three-plus (ANOVA
then a multiple-comparison procedure — Tukey, Scheffé, Bonferroni, Tukey-Kramer,
Marascuilo; Kruskal-Wallis if non-normal). The spine is test ⇔ interval duality:
reject exactly when the hypothesized value falls outside the matching confidence interval.
ANOVA analyzes variances to draw conclusions about means; fixed vs. random effects
changes the inferential target. Use exact methods for small samples, approximations
(with their validity gates) for large; "failure to reject" is not proof of equality.
Predicting how long it lasts — reliability (ch08)
Reliability is quality over time — R(t) = probability of surviving past t. The first
fork is non-repairable vs. repairable. Non-repairable units get a lifetime
distribution (Weibull, lognormal, exponential, gamma, extreme value, Birnbaum-Saunders),
reasoned about via the hazard rate h(t) (a speedometer) and the bathtub curve;
data are censored (Type I by time, Type II by count) and information scales with the
number of failures. Repairable systems get a repair-rate model (HPP; NHPP Power
Law / Duane-AMSAA for reliability growth under TAAF) reasoned about via N(t), M(t),
m(t) — they have no single failure rate. System reliability is built bottom-up
from series/parallel/k-of-n/standby blocks (series = product of part reliabilities).
Accelerated testing needs a justified acceleration model (Arrhenius, Eyring,
Coffin-Manson) that rescales time.
Chapter Index
| # |
Chapter file |
Topic |
Key content |
| 1 |
ch01 |
Exploratory Data Analysis |
EDA philosophy, univariate model, four assumptions, the 4-plot, residuals, problem categories |
| 2 |
ch02 |
Measurement Process Characterization |
Bias/precision/uncertainty, check standards, Level-1/2/3 model, calibration designs, gauge R&R, ISO/GUM uncertainty budgets |
| 3 |
ch03 |
Production Process Characterization |
Black-box & fishbone framing, CLM/ANOVA/discrete models, error propagation, stability vs. capability |
| 4 |
ch04 |
Process Modeling |
y = f(x;β)+ε, LS/WLS/NLS/LOESS, four uses of a model, six assumptions, residual analysis |
| 5 |
ch05 |
Process Improvement (DOE) |
Design objective classes, factorial/fractional/Plackett-Burman, resolution & confounding, response surface (CCD/Box-Behnken), Taguchi |
| 6 |
ch06 |
Process Monitoring & Control |
SPC, Shewhart/CUSUM/EWMA/attributes/multivariate charts, Phase I/II, ARL, capability, acceptance sampling |
| 7 |
ch07 |
Product & Process Comparisons |
Hypothesis tests & intervals for 1/2/3+ groups, test/interval duality, ANOVA, multiple comparisons, goodness-of-fit |
| 8 |
ch08 |
Assessing Product Reliability |
Lifetime & repair-rate models, bathtub curve, censoring, acceleration models, system reliability, reliability growth, Bayesian |
Topic Index
- 4-Plot / four univariate assumptions → ch01, cheatsheet
- Acceleration models (Arrhenius/Eyring/Coffin-Manson) → ch08
- Acceptance sampling / OC curve / AQL / LTPD → ch06, cheatsheet
- ANOVA (one-way / two-way / fixed-random effects) → ch07, ch03, ch05
- Average Run Length (ARL) → ch06
- Bathtub curve / hazard rate → ch08
- Bias / accuracy (measurement) → ch02
- Black-box & fishbone (cause-and-effect) diagram → ch03
- Calibration designs / restraint / drift & left-right bias → ch02
- Capability (Cp, Cpk) / stability vs. capability → ch06, ch03, cheatsheet
- Censoring (Type I / Type II) → ch08
- Check standard → ch02, patterns
- Confidence intervals / test–interval duality → ch07, cheatsheet
- Confounding / aliasing / resolution (III/IV/V) → ch05
- Control charts (Shewhart / CUSUM / EWMA / attributes / T²) → ch06, cheatsheet
- Design of Experiments (DOE) / objective classes → ch05, patterns
- EDA (exploratory data analysis) philosophy → ch01
- Error propagation / add variances / sensitivity coefficients → ch02, ch03, patterns
- Factorial & fractional factorial / Plackett-Burman → ch05
- Foldover / center points → ch05
- Gauge R&R (repeatability / reproducibility / stability) → ch02
- Goodness-of-fit (Anderson-Darling, K-S, chi-square, Shapiro-Wilk) → ch07, ch08
- Hotelling's T² (multivariate SPC) → ch06
- Hypothesis tests by group count (1/2/3+) → ch07, cheatsheet
- ISO/GUM uncertainty / Type A & Type B / expanded uncertainty → ch02, patterns, cheatsheet
- Lifetime distributions (Weibull / lognormal / exponential / gamma) → ch08, glossary
- LOESS / local regression → ch04
- Multiple-comparison procedures (Tukey / Scheffé / Bonferroni) → ch07
- Out-of-Control Action Plan (OCAP) → ch06
- Phase I vs. Phase II (SPC) → ch06
- Process model
y = f(x;β)+ε / regression (LS/WLS/NLS) → ch04
- Randomized block / completely randomized designs → ch05
- Reliability R(t) / non-repairable vs. repairable → ch08, patterns
- Reliability growth / Duane / AMSAA / TAAF → ch08
- Residual analysis → ch04, ch01
- Response surface (CCD / Box-Behnken / RSM) → ch05
- Run-sequence / lag / histogram / normal-probability plots → ch01
- Sampling / stratification / sample size → ch03
- Sequential experimentation strategy → ch05, patterns
- Series / parallel / k-of-n / standby system models → ch08
- Statistical Process Control (SPC / SQC) → ch06
- Taguchi / parameter & tolerance design → ch05
- Three-level standard-deviation model (Level 1/2/3) → ch02
- Uncertainty budgets / Welch-Satterthwaite → ch02, cheatsheet
- WECO rules / control vs. specification limits → ch06
Supporting Files
- glossary.md — key statistical, metrology, DOE, SPC, and reliability terms, alphabetical, with chapter references
- patterns.md — ten reusable techniques (4-plot gate, black-box framing, GUM uncertainty budget, stability-before-capability, chart selection, sequential DOE, comparison-test routing, reliability fork, check-standard control) with When/How/Trade-offs
- cheatsheet.md — chapter map, the four assumptions, comparison-test selector, control-chart selector, DOE & reliability decision tables, uncertainty-in-one-screen, and tells & smells
Scope & Limits
Covers: applied (frequentist) statistics for engineering, metrology, and quality across
the eight Handbook chapters — exploratory data analysis; measurement-process characterization
and ISO/GUM uncertainty; production-process characterization; process modeling and
regression; design of experiments; statistical process control and acceptance sampling;
hypothesis testing, confidence intervals, ANOVA and multiple comparisons; and product
reliability (lifetime models, accelerated testing, reliability growth, basic Bayesian
reliability).
Does not cover / thin on: the original web Handbook is an HTML/web-native reference of
many short interlinked pages with extensive per-distribution formula galleries, worked
case studies, datasets, plot/figure images, and Dataplot/R code blocks — this pack
synthesizes the concepts and method-selection logic in original words and deliberately
does not reproduce those galleries, case studies, datasets, images, or code (they are
described, not copied — a quality and licence-safety choice). It is also thin on: modern
machine learning / statistical learning; Bayesian methods beyond conjugate reliability
priors; time-series analysis and forecasting; Bayesian/optimal experimental design;
survey/causal-inference methodology; and software-specific how-tos. For SE-process context
see sebok, dau-se-guidebook, nasa-npr-7123; this pack is the quantitative-methods
companion to those.
Source version: NIST/SEMATECH e-Handbook of Statistical Methods, NIST Handbook 151
(2012 edition, last updated October 2022). Public domain — a work of the U.S. Government
(17 U.S.C. 105); free to reproduce, transform, and redistribute, including commercially.
SEMATECH co-developed the content; attribution to NIST/SEMATECH is a courtesy, not an
obligation, and neither endorses this pack.
1---2name: nist-stat-handbook3description: Knowledge base from the NIST/SEMATECH e-Handbook of Statistical Methods (NIST HB 151) — the practical statistics reference for engineering, metrology, and quality. Use for: exploratory data analysis and the four univariate assumptions (4-plot); measurement process characterization including bias/precision, calibration designs, gauge R&R, and ISO/GUM uncertainty budgets; production process characterization (stability vs. capability); process modeling and regression (LS/WLS/NLS/LOESS); design of experiments (screening, fractional/factorial, response-surface, Taguchi); statistical process control (Shewhart/CUSUM/EWMA charts, capability indices, acceptance sampling); product/process comparisons (hypothesis tests and confidence intervals for 1/2/3+ groups, ANOVA, multiple comparisons); and reliability (lifetime & repair-rate models, accelerated testing, reliability growth). Scope limits: this is applied frequentist statistics for measurement and quality — it does NOT reproduce the per-distribution formula gallerie4---56<!-- argument-hint: [statistical task: EDA/4-plot, uncertainty/GUM, calibration, gauge R&R, DOE/screening/response-surface, control chart, hypothesis test/ANOVA, reliability/Weibull/acceleration, capability, chapter number] -->78# NIST/SEMATECH e-Handbook of Statistical Methods (NIST HB 151)9**Source**: NIST/SEMATECH (US Government work, public domain) | **Chapters**: 81011## When to use12Use this skill when you need applied frequentist statistics for engineering, metrology, or quality work, drawing from the NIST/SEMATECH e-Handbook of Statistical Methods (NIST HB 151). It is the right pack for exploratory data analysis and the four univariate assumptions (4-plot), measurement process characterization including bias/precision, calibration designs, gauge R&R, and ISO/GUM uncertainty budgets, production process characterization covering stability vs. capability, process modeling and regression (LS/WLS/NLS/LOESS), design of experiments (screening, fractional/factorial, response-surface, Taguchi), statistical process control (Shewhart/CUSUM/EWMA charts, capability indices, acceptance sampling), product/process comparisons (hypothesis tests and confidence intervals for one, two, or more groups, ANOVA, multiple comparisons), and reliability (lifetime and repair-rate models, accelerated testing, reliability growth).1314**Prerequisites:** none, plain Markdown; no MCP server, API key, or licence tier needed at runtime.1516## How to Use This Skill17- **Without arguments** — load the Core Frameworks below: the EDA mindset, the18 characterization→modeling→improvement→control→comparison→reliability arc, and the19 routing rules for picking a method.20- **With a statistical task** — route to the right chapter and pattern. Examples:21 "is my data in control?" → ch01 (4-plot); "state the uncertainty of this result" →22 ch02 (GUM budget); "design an experiment to optimize yield" → ch05 (DOE);23 "which control chart for small drifts?" → ch06 (CUSUM/EWMA); "compare three machines"24 → ch07 (ANOVA + multiple comparisons); "fit a life distribution" → ch08 (Weibull).25- **With a chapter** — `ch01` EDA · `ch02` measurement/uncertainty · `ch03` process26 characterization · `ch04` regression · `ch05` DOE · `ch06` SPC · `ch07` comparisons ·27 `ch08` reliability.2829Supporting files: `glossary.md`, `patterns.md`, `cheatsheet.md`.3031**Prerequisites:** none — plain Markdown; no MCP server, API key, or runtime licence needed.3233> **What this Handbook is.** A practitioner's reference for *engineering statistics* —34> measurement, process, and quality work — not a mathematical-statistics textbook. Its35> through-line is the **engineering scientific method**: characterize a process, model it,36> improve it by experiment, hold the gains with control charts, compare alternatives with37> the right test, and predict how long it will last. The signature attitude (from ch01)38> is **look at the data before imposing a model.**3940## Core Frameworks & Mental Models4142### The EDA stance — let the data reveal the model (ch01)43Classical analysis imposes a model (normality, linearity), then estimates and tests it.44**Exploratory Data Analysis (EDA)** holds that decision back: plot the data first and let45its structure surface. The unifying baseline is the **univariate model** `Y = c + ε` and46its **four assumptions** — the data have (1) fixed location, (2) fixed scale, (3) randomness47(no autocorrelation), and (4) a fixed distribution. The **4-Plot** (run-sequence, lag,48histogram, normal-probability) tests all four at a glance. Pass all four ⇒ the process is49"in statistical control" and predictable. A failed panel is a *diagnostic* pointing at a50physical cause. **Residuals** are the universal diagnostic: an adequate model leaves51structureless residuals.5253### Characterizing a measurement process — goodness decomposed (ch02)54Treat measurements as the output of a process and ask how *good* they are. Goodness splits55into **bias** (quantitative offset from the reference/true value), **short-term variability56/ precision** (level-1), **long-term / day-to-day variability** (level-2, often *larger*57than precision for very precise instruments), and **uncertainty**. The engine is the58**check standard** — a database of repeated measurements on a stable surrogate — monitored59by an **individuals Shewhart chart** (and **EWMA** for small shifts). **Calibration designs**60are redundant least-squares intercomparison schedules (anchored by a **restraint** = the61known reference value) that assign values while cancelling constant **left-right bias** and62linear **drift**. **Gauge R&R** nested designs separate repeatability, reproducibility, and63stability. Uncertainty follows the **ISO/GUM** framework: every component a standard64deviation, grouped by **Type A** (from statistical analysis) vs. **Type B** (other means),65combined by **root-sum-squares** with **sensitivity coefficients**, expanded by a coverage66factor `U = k·u` (k≈2 ⇒ ~95%), with **Welch-Satterthwaite** for unknown degrees of freedom.6768### Characterizing a production process — stability before capability (ch03)69Frame the process as a **black box** (inputs / controlled factors / uncontrolled noise /70output), then expand drivers with a **fishbone** diagram. Distribution = **location +71spread + shape**. Models span the **Continuous Linear Model (CLM)**, **ANOVA**, and72**discrete (contingency/chi-square)** forms. Two rules dominate: **add variances, never73standard deviations** when combining error; and **establish stability before claiming74capability** — Cp/Cpk on an out-of-control process are meaningless. Interpret graphically,75then confirm numerically. The most expensive mistake is skimping on planning.7677### Modeling a process — function plus error (ch04)78The general statistical model is `y = f(x; β) + ε`: a deterministic function of the factors79plus random error. Four method families build it — **linear least squares**, **nonlinear80least squares**, **weighted least squares (WLS)** for non-constant variance, and **LOESS**81for local, assumption-light smoothing. A model is used to **estimate, predict, calibrate,82and optimize**. Six standard assumptions (random errors, mean zero, constant variance,83known distribution, independence, correct functional form) are checked through **residual84analysis** — the same look-at-the-residuals discipline as EDA.8586### Improving by experiment — sequential DOE (ch05)87**Design of Experiments** varies factors *together* to estimate effects efficiently; its88four objective classes are **comparative, screening, response-surface, and regression**.89The strategy is a **staircase**, not one big experiment: screen many factors cheaply with90**fractional factorial / Plackett-Burman** designs, test curvature with **center points**,91**foldover** to de-alias, then spend three-level **response-surface** runs (**CCD**,92**Box-Behnken**) near the optimum. **Resolution** (III/IV/V) is the confounding dial; the93**defining relation** and **generators** set the **aliasing**. **One-factor-at-a-time is a94trap** — it misses interactions. **Taguchi** robust design (parameter design via inner/outer95arrays, then tolerance design) minimizes sensitivity to noise. Always randomize; finish with96**confirmation runs**.9798### Holding the gains — statistical process control (ch06)99**SPC/SQC** uses control charts to separate common-cause from special-cause variation.100**Phase I** builds and validates limits from history; **Phase II** monitors new data.101Chart families: **Shewhart** (X-bar & R/s, individuals) for large shifts; **CUSUM** (V-mask)102and **EWMA** (memory depth λ) for small sustained drifts; **attributes** charts for counts;103**Hotelling's T²** for correlated multivariate data. **Control limits ≠ specification104limits** (voice of the process vs. voice of the customer). Compare charts by **Average Run105Length (ARL)**: sensitivity is bought with false alarms (**WECO rules**). Decide the response106in advance with an **OCAP**. **Acceptance sampling** (OC curve, AQL/LTPD, producer's/107consumer's risk, AOQ/AOQL) governs lot accept/reject decisions.108109### Comparing alternatives — the right test (ch07)110Route by **how many processes**: one (t/z, chi-square, exact-binomial/Wilson), two111(two-sample/paired t, F-test, two-proportion z / Fisher exact), or three-plus (**ANOVA**112then a **multiple-comparison** procedure — Tukey, Scheffé, Bonferroni, Tukey-Kramer,113Marascuilo; **Kruskal-Wallis** if non-normal). The spine is **test ⇔ interval duality**:114reject exactly when the hypothesized value falls outside the matching confidence interval.115ANOVA **analyzes variances to draw conclusions about means**; fixed vs. random effects116changes the inferential target. Use **exact** methods for small samples, **approximations**117(with their validity gates) for large; **"failure to reject" is not proof of equality.**118119### Predicting how long it lasts — reliability (ch08)120**Reliability is quality over time** — R(t) = probability of surviving past t. The first121fork is **non-repairable vs. repairable**. Non-repairable units get a **lifetime122distribution** (Weibull, lognormal, exponential, gamma, extreme value, Birnbaum-Saunders),123reasoned about via the **hazard rate** h(t) (a *speedometer*) and the **bathtub curve**;124data are **censored** (Type I by time, Type II by count) and information scales with the125number of **failures**. Repairable systems get a **repair-rate** model (HPP; **NHPP Power126Law / Duane-AMSAA** for **reliability growth** under **TAAF**) reasoned about via N(t), M(t),127m(t) — they have *no single failure rate*. **System reliability** is built **bottom-up**128from series/parallel/k-of-n/standby blocks (series = product of part reliabilities).129**Accelerated testing** needs a justified **acceleration model** (Arrhenius, Eyring,130Coffin-Manson) that rescales time.131132---133134## Chapter Index135136| # | Chapter file | Topic | Key content |137|---|---|---|---|138| 1 | [ch01](chapters/ch01-nist-stat-handbook-exploratory-data-analysis.md) | Exploratory Data Analysis | EDA philosophy, univariate model, four assumptions, the 4-plot, residuals, problem categories |139| 2 | [ch02](chapters/ch02-nist-stat-handbook-measurement-process-characterization.md) | Measurement Process Characterization | Bias/precision/uncertainty, check standards, Level-1/2/3 model, calibration designs, gauge R&R, **ISO/GUM uncertainty budgets** |140| 3 | [ch03](chapters/ch03-nist-stat-handbook-production-process-characterization.md) | Production Process Characterization | Black-box & fishbone framing, CLM/ANOVA/discrete models, error propagation, stability vs. capability |141| 4 | [ch04](chapters/ch04-nist-stat-handbook-process-modeling.md) | Process Modeling | `y = f(x;β)+ε`, LS/WLS/NLS/LOESS, four uses of a model, six assumptions, residual analysis |142| 5 | [ch05](chapters/ch05-nist-stat-handbook-process-improvement-doe.md) | Process Improvement (DOE) | Design objective classes, factorial/fractional/Plackett-Burman, resolution & confounding, response surface (CCD/Box-Behnken), Taguchi |143| 6 | [ch06](chapters/ch06-nist-stat-handbook-process-monitoring-and-control.md) | Process Monitoring & Control | SPC, Shewhart/CUSUM/EWMA/attributes/multivariate charts, Phase I/II, ARL, capability, acceptance sampling |144| 7 | [ch07](chapters/ch07-nist-stat-handbook-product-and-process-comparisons.md) | Product & Process Comparisons | Hypothesis tests & intervals for 1/2/3+ groups, test/interval duality, ANOVA, multiple comparisons, goodness-of-fit |145| 8 | [ch08](chapters/ch08-nist-stat-handbook-assessing-product-reliability.md) | Assessing Product Reliability | Lifetime & repair-rate models, bathtub curve, censoring, acceleration models, system reliability, reliability growth, Bayesian |146147## Topic Index148149- **4-Plot / four univariate assumptions** → ch01, cheatsheet150- **Acceleration models (Arrhenius/Eyring/Coffin-Manson)** → ch08151- **Acceptance sampling / OC curve / AQL / LTPD** → ch06, cheatsheet152- **ANOVA (one-way / two-way / fixed-random effects)** → ch07, ch03, ch05153- **Average Run Length (ARL)** → ch06154- **Bathtub curve / hazard rate** → ch08155- **Bias / accuracy (measurement)** → ch02156- **Black-box & fishbone (cause-and-effect) diagram** → ch03157- **Calibration designs / restraint / drift & left-right bias** → ch02158- **Capability (Cp, Cpk) / stability vs. capability** → ch06, ch03, cheatsheet159- **Censoring (Type I / Type II)** → ch08160- **Check standard** → ch02, patterns161- **Confidence intervals / test–interval duality** → ch07, cheatsheet162- **Confounding / aliasing / resolution (III/IV/V)** → ch05163- **Control charts (Shewhart / CUSUM / EWMA / attributes / T²)** → ch06, cheatsheet164- **Design of Experiments (DOE) / objective classes** → ch05, patterns165- **EDA (exploratory data analysis) philosophy** → ch01166- **Error propagation / add variances / sensitivity coefficients** → ch02, ch03, patterns167- **Factorial & fractional factorial / Plackett-Burman** → ch05168- **Foldover / center points** → ch05169- **Gauge R&R (repeatability / reproducibility / stability)** → ch02170- **Goodness-of-fit (Anderson-Darling, K-S, chi-square, Shapiro-Wilk)** → ch07, ch08171- **Hotelling's T² (multivariate SPC)** → ch06172- **Hypothesis tests by group count (1/2/3+)** → ch07, cheatsheet173- **ISO/GUM uncertainty / Type A & Type B / expanded uncertainty** → ch02, patterns, cheatsheet174- **Lifetime distributions (Weibull / lognormal / exponential / gamma)** → ch08, glossary175- **LOESS / local regression** → ch04176- **Multiple-comparison procedures (Tukey / Scheffé / Bonferroni)** → ch07177- **Out-of-Control Action Plan (OCAP)** → ch06178- **Phase I vs. Phase II (SPC)** → ch06179- **Process model `y = f(x;β)+ε` / regression (LS/WLS/NLS)** → ch04180- **Randomized block / completely randomized designs** → ch05181- **Reliability R(t) / non-repairable vs. repairable** → ch08, patterns182- **Reliability growth / Duane / AMSAA / TAAF** → ch08183- **Residual analysis** → ch04, ch01184- **Response surface (CCD / Box-Behnken / RSM)** → ch05185- **Run-sequence / lag / histogram / normal-probability plots** → ch01186- **Sampling / stratification / sample size** → ch03187- **Sequential experimentation strategy** → ch05, patterns188- **Series / parallel / k-of-n / standby system models** → ch08189- **Statistical Process Control (SPC / SQC)** → ch06190- **Taguchi / parameter & tolerance design** → ch05191- **Three-level standard-deviation model (Level 1/2/3)** → ch02192- **Uncertainty budgets / Welch-Satterthwaite** → ch02, cheatsheet193- **WECO rules / control vs. specification limits** → ch06194195## Supporting Files196197- [glossary.md](glossary.md) — key statistical, metrology, DOE, SPC, and reliability terms, alphabetical, with chapter references198- [patterns.md](patterns.md) — ten reusable techniques (4-plot gate, black-box framing, GUM uncertainty budget, stability-before-capability, chart selection, sequential DOE, comparison-test routing, reliability fork, check-standard control) with When/How/Trade-offs199- [cheatsheet.md](cheatsheet.md) — chapter map, the four assumptions, comparison-test selector, control-chart selector, DOE & reliability decision tables, uncertainty-in-one-screen, and tells & smells200201---202203## Scope & Limits204205**Covers**: applied (frequentist) statistics for engineering, metrology, and quality across206the eight Handbook chapters — exploratory data analysis; measurement-process characterization207and ISO/GUM uncertainty; production-process characterization; process modeling and208regression; design of experiments; statistical process control and acceptance sampling;209hypothesis testing, confidence intervals, ANOVA and multiple comparisons; and product210reliability (lifetime models, accelerated testing, reliability growth, basic Bayesian211reliability).212213**Does not cover / thin on**: the original web Handbook is an HTML/web-native reference of214many short interlinked pages with extensive **per-distribution formula galleries, worked215case studies, datasets, plot/figure images, and Dataplot/R code blocks** — this pack216**synthesizes the concepts and method-selection logic in original words and deliberately217does not reproduce** those galleries, case studies, datasets, images, or code (they are218described, not copied — a quality and licence-safety choice). It is also **thin on**: modern219machine learning / statistical learning; Bayesian methods beyond conjugate reliability220priors; time-series analysis and forecasting; Bayesian/optimal experimental design;221survey/causal-inference methodology; and software-specific how-tos. For SE-process context222see `sebok`, `dau-se-guidebook`, `nasa-npr-7123`; this pack is the quantitative-methods223companion to those.224225**Source version**: NIST/SEMATECH e-Handbook of Statistical Methods, **NIST Handbook 151**226(2012 edition, last updated October 2022). **Public domain** — a work of the U.S. Government227(17 U.S.C. 105); free to reproduce, transform, and redistribute, including commercially.228SEMATECH co-developed the content; attribution to NIST/SEMATECH is a courtesy, not an229obligation, and neither endorses this pack.