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Run npx skillmds@latest add kdevos12/organic-mechanisms in your terminal (requires Node.js), paste this page's agent-chat prompt into Claude, Cursor, or any MCP-connected agent, or download the SKILL.md file and copy it into your agent's skills directory.

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Is Organic Mechanisms free to use?

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Who published Organic Mechanisms?

Kdevos12 (@kdevos12) published this skill. Their other Agent Skills are listed on their SkillMD profile.

Organic Mechanisms by kdevos12 — Agent Skill

Name: Organic Mechanisms
Author: Kdevos12

Organic Mechanisms

Use when reasoning about polar organic reaction mechanisms, arrow pushing, SN1/SN2/E1/E2, nucleophile/electrophile identification, Zaitsev/Hofmann selectivity, HSAB rules, or retrosynthesis. Applies the EASE framework step-by-step.

Kdevos12 790a607 7 files · 21.7 KB Updated Sep 17, 2026

File contents

Organic Mechanisms — EASE Framework

Source: AceOrganicChem.com Ace Organic Chemistry Mechanisms with E.A.S.E. (2013) + standard references (Clayden, March).

When to Use

Any polar organic mechanism or synthesis problem. Apply EASE iteratively — one step at a time, rinse and repeat.

The Four Steps (Quick Reference)

E — Electrophile   Identify E+ and Nu−. Use resonance if unclear.
A — Acid/Base      Strong acid/base present? Move proton FIRST before continuing.
S — Sterics        Bulky group on Nu or E+? Reassess: block / carbocation / overcome.
E — Electron Flow  Nu− → E+. Draw curved arrows. Check valence. Done?
                   If not, repeat from Step 1 with new intermediates.

Reference Files

File	Content
`ease-framework.md`	Full step-by-step logic, decision rules, worked examples
`electrophiles-nucleophiles.md`	Identification rules, pKa table, nucleophilicity scales
`sterics-substitution.md`	SN1/SN2/E1/E2 decision tree, steric groups, Zaitsev/Hofmann
`electron-flow.md`	Arrow pushing, HSAB (1,2 vs 1,4), intra vs inter, stereochemistry
`retrosynthesis.md`	Disconnections, synthons, FGI, toolbox (C–C / C–X / FGI)
`method-limits.md`	When EASE fails: RedOx table, radicals, organometallics

Quick Routing

"What is the mechanism?" → ease-framework.md "Which product forms?" → sterics-substitution.md (SN/E) or electron-flow.md (HSAB) "How do I make X from Y?" → retrosynthesis.md "Reagent does something weird" → method-limits.md "I can't find the nucleophile" → electrophiles-nucleophiles.md (draw resonance structures)

Core Rule

Electrons always flow from nucleophile to electrophile. Arrows point to where electrons are going. If you cannot identify a nucleophile, draw all resonance structures first.

---name: organic-mechanismsdescription: Use when reasoning about polar organic reaction mechanisms, arrow pushing, SN1/SN2/E1/E2, nucleophile/electrophile identification, Zaitsev/Hofmann selectivity, HSAB rules, or retrosynthesis. Applies the EASE framework step-by-step.---# Organic Mechanisms — EASE Framework**Source**: AceOrganicChem.com *Ace Organic Chemistry Mechanisms with E.A.S.E.* (2013) + standard references (Clayden, March).## When to UseAny polar organic mechanism or synthesis problem. Apply EASE iteratively — one step at a time, rinse and repeat.## The Four Steps (Quick Reference)```E — Electrophile Identify E+ and Nu−. Use resonance if unclear.A — Acid/Base Strong acid/base present? Move proton FIRST before continuing.S — Sterics Bulky group on Nu or E+? Reassess: block / carbocation / overcome.E — Electron Flow Nu− → E+. Draw curved arrows. Check valence. Done? If not, repeat from Step 1 with new intermediates.```## Reference Files| File | Content ||------|---------|| `ease-framework.md` | Full step-by-step logic, decision rules, worked examples || `electrophiles-nucleophiles.md` | Identification rules, pKa table, nucleophilicity scales || `sterics-substitution.md` | SN1/SN2/E1/E2 decision tree, steric groups, Zaitsev/Hofmann || `electron-flow.md` | Arrow pushing, HSAB (1,2 vs 1,4), intra vs inter, stereochemistry || `retrosynthesis.md` | Disconnections, synthons, FGI, toolbox (C–C / C–X / FGI) || `method-limits.md` | When EASE fails: RedOx table, radicals, organometallics |## Quick Routing**"What is the mechanism?"** → `ease-framework.md`**"Which product forms?"** → `sterics-substitution.md` (SN/E) or `electron-flow.md` (HSAB)**"How do I make X from Y?"** → `retrosynthesis.md`**"Reagent does something weird"** → `method-limits.md`**"I can't find the nucleophile"** → `electrophiles-nucleophiles.md` (draw resonance structures)## Core Rule> Electrons *always* flow from nucleophile to electrophile.> Arrows point to where electrons are *going*.> If you cannot identify a nucleophile, draw all resonance structures first.

Frequently asked questions