Mutation Generator

Generate conservative vs aggressive peptide mutation variants given a reference sequence and optional protected/hotspot positions.

lamm-mit c733205 3 files · 13.2 KB Updated

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Mutation Generator

Creates a small mutation space for a peptide scaffold.

  • Conservative: substitutions within broad physicochemical groups
  • Aggressive: larger substitutions, multiple mutations

CLI

python3 scripts/run.py --sequence AGCKNFFWKTFTSC --strategy conservative --n-variants 8
python3 scripts/run.py --sequence AGCKNFFWKTFTSC --strategy aggressive --max-mutations 3 --n-variants 12

lamm-mit/scienceclaw/tree/main/skills/mutation-generator commit c7332052b8

Frequently asked questions

npx skillmds@latest add lamm-mit/mutation-generator