majiayu000 Experiment Design Skill
Purpose
Design methodologically rigorous experiments with appropriate controls and randomization.
Key Design Elements
1. Research Question: Clear, testable hypothesis 2. Study Design: RCT, quasi-experimental, observational 3. Sample Size: Power analysis justified 4. Randomization: Method specified 5. Blinding: Who is blinded 6. Controls: Appropriate comparison groups 7. Outcomes: Primary and secondary clearly defined 8. Analysis Plan: Pre-specified statistical approach
Common Designs
Between-Subjects: Different participants per condition Within-Subjects: Same participants, repeated measures Factorial: Multiple factors (2x2, 2x3) Crossover: Participants receive all treatments Stepped-Wedge: Phased rollout
NIH Rigor Checklist
- Scientific premise established
- Rigorous design (appropriate controls)
- Biological variables considered (SABV)
- Authentication of key resources
- Transparent reporting planned
Version: 1.0.0