Systematic review
Systematic review skill. PRISMA-compliant systematic review workflow, literature screening, data extraction, risk of bias assessment, and evidence synthesis.
Use This Skill When
- PRISMA-compliant systematic review workflow.
- Literature screening.
- Data extraction.
- Risk of bias assessment.
- Evidence synthesis.
Required Inputs
- Research objective, decision target, or hypothesis.
- Available data, source constraints, and domain assumptions.
- Required outputs, success metrics, and deadline or reproducibility constraints.
Workflow
- Confirm scope, assumptions, and the exact artifact set to save.
- Apply the narrowest domain method that answers the request with defensible evidence.
- Save code, tables, figures, and intermediate outputs to files instead of chat-only output.
- State limitations, uncertainty, and any validation or sensitivity checks performed.
- Append skill selection, handoff I/O, and file writes to
logs/process-log.jsonl.
Deliverables
report.md: concise method, results, interpretation, and file inventory in the user's language.
results/: structured outputs, metrics, model artifacts, or extracted findings.
figures/: English-only charts, diagrams, or panels when visual output is needed.
data/: processed or derived datasets when transformation occurs.
Available Tools (MCP)
External tools available via ToolUniverse MCP server.
Falls back to Python requests + public REST APIs when MCP is unavailable.
| Source |
Tool |
Description |
| PubMed |
PubMed_search |
PubMed API |
| PubMed |
PubMed_get_article |
PubMed API |
| EuropePMC |
EuropePMC_search |
EuropePMC API |
| Crossref |
Crossref_search_works |
Crossref API |
Quality Gates
If any gate fails: identify the specific failing check, fix the issue, and re-validate before proceeding.
Gotchas
- Input data quality must be verified before analysis. Garbage-in-garbage-out is the most common cause of incorrect results
- All intermediate results must be saved to files, not kept only in chat. Session compaction will lose unsaved work
- Method selection rationale must be documented. A correctly applied simple method outperforms a misapplied sophisticated one
Validation Loop
- Execute analysis and generate outputs
- Check:
- Method selection matches the research question and stated assumptions
- All outputs are saved to files (no chat-only results)
- Limitations and uncertainty are explicitly stated
logs/process-log.jsonl is updated with execution trace
- If any check fails:
- Identify the failing gate
- Fix the specific issue
- Re-run validation
- Proceed only after all gates pass
1---2name: co-scientist-systematic-review3description: Systematic review skill. PRISMA-compliant systematic review workflow, literature screening, data extraction, risk of bias assessment, and evidence synthesis. Use when working with prisma-compliant systematic review workflow, literature screening, data extraction.4---56# Systematic review78Systematic review skill. PRISMA-compliant systematic review workflow, literature screening, data extraction, risk of bias assessment, and evidence synthesis.910## Use This Skill When1112- PRISMA-compliant systematic review workflow.13- Literature screening.14- Data extraction.15- Risk of bias assessment.16- Evidence synthesis.1718## Required Inputs1920- Research objective, decision target, or hypothesis.21- Available data, source constraints, and domain assumptions.22- Required outputs, success metrics, and deadline or reproducibility constraints.2324## Workflow25261. Confirm scope, assumptions, and the exact artifact set to save.272. Apply the narrowest domain method that answers the request with defensible evidence.283. Save code, tables, figures, and intermediate outputs to files instead of chat-only output.294. State limitations, uncertainty, and any validation or sensitivity checks performed.305. Append skill selection, handoff I/O, and file writes to `logs/process-log.jsonl`.3132## Deliverables3334- `report.md`: concise method, results, interpretation, and file inventory in the user's language.35- `results/`: structured outputs, metrics, model artifacts, or extracted findings.36- `figures/`: English-only charts, diagrams, or panels when visual output is needed.37- `data/`: processed or derived datasets when transformation occurs.3839## Available Tools (MCP)4041> External tools available via [ToolUniverse](https://github.com/mims-harvard/ToolUniverse) MCP server.42> Falls back to Python `requests` + public REST APIs when MCP is unavailable.4344| Source | Tool | Description |45|--------|------|-------------|46| PubMed | `PubMed_search` | PubMed API |47| PubMed | `PubMed_get_article` | PubMed API |48| EuropePMC | `EuropePMC_search` | EuropePMC API |49| Crossref | `Crossref_search_works` | Crossref API |5051## Quality Gates5253- [ ] The selected method matches the scientific question and stated assumptions.54- [ ] Outputs are reproducible, saved to files, and traceable from inputs to conclusions.55- [ ] Missing data, uncertainty, bias, and hard limits are made explicit.56- [ ] `report.md` and `logs/process-log.jsonl` reference the generated artifacts.57- [ ] No essential result remains chat-only.5859If any gate fails: identify the specific failing check, fix the issue, and re-validate before proceeding.6061## Gotchas6263- Input data quality must be verified before analysis. Garbage-in-garbage-out is the most common cause of incorrect results64- All intermediate results must be saved to files, not kept only in chat. Session compaction will lose unsaved work65- Method selection rationale must be documented. A correctly applied simple method outperforms a misapplied sophisticated one6667## Validation Loop68691. Execute analysis and generate outputs702. Check:71 - Method selection matches the research question and stated assumptions72 - All outputs are saved to files (no chat-only results)73 - Limitations and uncertainty are explicitly stated74 - `logs/process-log.jsonl` is updated with execution trace753. If any check fails:76 - Identify the failing gate77 - Fix the specific issue78 - Re-run validation794. Proceed only after all gates pass