研究假說驗證與可行性評估技能
純指令技能。LLM 醫學知識 + compare_with_literature, list_saved_references, search_local_references, validate_concept。
觸發:hypothesis、假說、PICO、feasibility、可行性、testable、研究計畫評估
Framework 1: Hypothesis Validation
Step 1: PICO 分析
| Component |
偵測重點 |
| Population |
patients, subjects, ICU, surgical... |
| Intervention |
treatment, therapy, drug, procedure... |
| Comparison |
versus, vs, placebo, standard, control... |
| Outcome |
mortality, survival, recovery, score, rate... |
Step 2: Testability
- Directional — higher/lower/better/worse/reduce? ✅ vs 只有描述性 ❌
- Comparison — significantly/compared/than? ✅ vs 缺基準 ❌
- Type — Null (no difference) vs Alternative (有方向)
- Specificity — <10 words 太模糊, 10-50 適當, >50 過複雜
Step 3: Study Type Recommendation
| 假說特徵 |
建議設計 |
| effect/efficacy/treatment |
RCT or Cohort |
| risk factor/association |
Cohort or Case-Control |
| prevalence/frequency |
Cross-Sectional |
Framework 2: Feasibility Assessment
Sample Size Quick Check
| 類型 |
注意 |
| N ≤ 10 |
Case report/series |
| N < 30 RCT |
Pilot or crossover |
| N ≥ 100 |
大多設計合理 |
Timeline by Study Type
| 類型 |
IRB |
主要工作 |
分析寫作 |
| RCT |
2 mo |
招募+收案 ÷3 |
÷4 |
| Retrospective |
1 mo |
資料萃取 2 mo |
÷2 |
| SR |
1 mo (protocol) |
搜尋+篩選 ÷3 |
÷3 |
Feasibility Checklist (17 items, 5 categories)
| Category |
Critical Items |
High Items |
| Data & Sample |
資料可及、樣本可達 |
納排標準 |
| Ethics |
IRB plan、informed consent |
privacy |
| Resources |
— |
funding, timeline, team, equipment |
| Methodology |
primary outcome |
stat plan, validated tools, confounders |
| Publication |
— |
target journal, reporting guideline, novelty |
All Critical items must be ✅ before proceeding.
使用原則
- PICO 分析用語意理解,非關鍵字匹配
- 可行性評估寧可保守
- 文獻比較用
compare_with_literature MCP tool
1---2name: idea-validation3description: 研究假說驗證與可行性評估框架。 LOAD THIS SKILL WHEN: hypothesis、假說、PICO、feasibility、可行性、testable、可驗證、研究計畫評估、check feasibility CAPABILITIES: 純指令技能,不需要專屬 MCP tool。利用 LLM 推理能力 + 現有 tools (list_saved_references, search_local_references) 完成分析。4---56# 研究假說驗證與可行性評估技能78純指令技能。LLM 醫學知識 + `compare_with_literature`, `list_saved_references`, `search_local_references`, `validate_concept`。910觸發:hypothesis、假說、PICO、feasibility、可行性、testable、研究計畫評估1112---1314## Framework 1: Hypothesis Validation1516### Step 1: PICO 分析1718| Component | 偵測重點 |19| ---------------- | --------------------------------------------- |20| **P**opulation | patients, subjects, ICU, surgical... |21| **I**ntervention | treatment, therapy, drug, procedure... |22| **C**omparison | versus, vs, placebo, standard, control... |23| **O**utcome | mortality, survival, recovery, score, rate... |2425### Step 2: Testability26271. **Directional** — higher/lower/better/worse/reduce? ✅ vs 只有描述性 ❌282. **Comparison** — significantly/compared/than? ✅ vs 缺基準 ❌293. **Type** — Null (no difference) vs Alternative (有方向)304. **Specificity** — <10 words 太模糊, 10-50 適當, >50 過複雜3132### Step 3: Study Type Recommendation3334| 假說特徵 | 建議設計 |35| ------------------------- | ---------------------- |36| effect/efficacy/treatment | RCT or Cohort |37| risk factor/association | Cohort or Case-Control |38| prevalence/frequency | Cross-Sectional |3940---4142## Framework 2: Feasibility Assessment4344### Sample Size Quick Check4546| 類型 | 注意 |47| ---------- | ------------------ |48| N ≤ 10 | Case report/series |49| N < 30 RCT | Pilot or crossover |50| N ≥ 100 | 大多設計合理 |5152### Timeline by Study Type5354| 類型 | IRB | 主要工作 | 分析寫作 |55| ------------- | --------------- | ------------- | -------- |56| RCT | 2 mo | 招募+收案 ÷3 | ÷4 |57| Retrospective | 1 mo | 資料萃取 2 mo | ÷2 |58| SR | 1 mo (protocol) | 搜尋+篩選 ÷3 | ÷3 |5960### Feasibility Checklist (17 items, 5 categories)6162| Category | Critical Items | High Items |63| ------------- | -------------------------- | -------------------------------------------- |64| Data & Sample | 資料可及、樣本可達 | 納排標準 |65| Ethics | IRB plan、informed consent | privacy |66| Resources | — | funding, timeline, team, equipment |67| Methodology | primary outcome | stat plan, validated tools, confounders |68| Publication | — | target journal, reporting guideline, novelty |6970**All Critical items must be ✅ before proceeding.**7172---7374## 使用原則75761. PICO 分析用語意理解,非關鍵字匹配772. 可行性評估寧可保守783. 文獻比較用 `compare_with_literature` MCP tool