Heterogeneity Source Analysis

Identify and classify sources of between-study heterogeneity (clinical, methodological, statistical)

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Heterogeneity Source Analysis SOP

Systematically identify, classify, and prioritize potential sources of between-study heterogeneity for investigation via subgroup analysis and meta-regression.

When to Use

  • When meta-analysis reveals substantial heterogeneity (I2 > 50%)
  • During planning of subgroup analyses and meta-regression
  • When assessing the transitivity assumption in network meta-analysis

Input

  • study_characteristics: Study-level characteristics and covariates
  • effect_sizes: Extracted effect sizes showing variation
  • moderator_candidates: Pre-specified candidate moderator variables

Output

Classified sources of heterogeneity with investigation priority and statistical analysis plan.

Available SOPs

Optional, no fixed order; the final leaf is always a sop.

SOP When to use
spawn-agent Spawn a customized CC subagent with full MCP tool access. Used by SOPs that declare execution: subagent.

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Frequently asked questions

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