Heterogeneity Source Analysis SOP
Systematically identify, classify, and prioritize potential sources of between-study heterogeneity for investigation via subgroup analysis and meta-regression.
When to Use
- When meta-analysis reveals substantial heterogeneity (I2 > 50%)
- During planning of subgroup analyses and meta-regression
- When assessing the transitivity assumption in network meta-analysis
Input
study_characteristics: Study-level characteristics and covariateseffect_sizes: Extracted effect sizes showing variationmoderator_candidates: Pre-specified candidate moderator variables
Output
Classified sources of heterogeneity with investigation priority and statistical analysis plan.
Available SOPs
Optional, no fixed order; the final leaf is always a sop.
| SOP | When to use |
|---|---|
| spawn-agent | Spawn a customized CC subagent with full MCP tool access. Used by SOPs that declare execution: subagent. |