Meta-Analysis Campaign
Cross-study statistical synthesis — systematic collection and methodological planning for multi-study evidence synthesis. This campaign orchestrates the full meta-analysis planning pipeline from PICO formulation through protocol design, stopping before computation.
Strategy Routing
| Trigger |
Strategy |
When |
| Two-arm comparison |
pairwise-synthesis |
Comparing method A vs B across studies |
| Multi-method comparison |
network-comparison |
Comparing N>=3 methods with indirect evidence |
| Temporal evidence tracking |
cumulative-tracking |
Tracking how evidence evolves over time |
| Inconsistent findings |
heterogeneity-investigation |
Studies disagree — explain why |
| Evidence reliability |
bias-detection |
Assess systematic biases in evidence body |
Manifest
Strategies (5)
| Strategy |
Purpose |
| pairwise-synthesis |
Paired meta-analysis protocol for two-method comparison |
| network-comparison |
Network meta-analysis for N-method simultaneous comparison |
| cumulative-tracking |
Cumulative meta-analysis tracking evidence over time |
| heterogeneity-investigation |
Explain inter-study variation in findings |
| bias-detection |
Systematic bias assessment of evidence body |
Tactics (3)
| Tactic |
Purpose |
| effect-size-extraction |
Extract effect sizes and conditions from papers |
| quality-assessment-protocol |
Methodological quality and bias risk assessment |
| evidence-synthesis-planning |
Plan the statistical synthesis approach |
Subagent SOPs (10)
| SOP |
Purpose |
| pico-formulation |
Construct PICO/PECO framework |
| inclusion-criteria-design |
Define inclusion/exclusion criteria |
| effect-size-planning |
Determine effect size types and calculation methods |
| data-extraction-form |
Design structured data extraction form |
| risk-of-bias-assessment |
Assess methodological bias (RoB2/PROBAST/QUADAS-2) |
| heterogeneity-source-analysis |
Identify and classify heterogeneity sources |
| publication-bias-assessment |
Plan funnel plots, Egger's test, trim-and-fill, p-curve |
| sensitivity-analysis-design |
Design leave-one-out, influence diagnostics, subgroups |
| evidence-network-construction |
Build evidence network graph for NMA |
| meta-analysis-synthesis |
Produce final meta-analysis protocol document |
Budget Table
| Strategy |
Studies |
Effect Sizes |
Web Searches |
| pairwise-synthesis |
30 |
30 |
40 |
| network-comparison |
50 |
80 |
60 |
| cumulative-tracking |
40 |
40 |
30 |
| heterogeneity-investigation |
30 |
30 |
50 |
| bias-detection |
40 |
40 |
40 |
MCP Tools
| MCP Server |
Tools |
| brave-search |
brave_web_search, brave_llm_context |
| apify |
rag-web-browser, google-scholar-scraper |
| alphaxiv |
get_paper_content, answer_pdf_queries |
| semantic-scholar |
ss_relevance_search, ss_paper, ss_references, ss_citations |
Context Management
- Input: Research question, domain, candidate studies (optional)
- State: Strategy state ledgers track studies found, effect sizes extracted, quality assessed
- Output: Complete meta-analysis protocol document (PRISMA-compliant)
- Persistence: All intermediate outputs stored in
context/meta-analysis/ subdirectories per strategy
Available Strategies
Optional, no fixed order; the final leaf is always a sop.
| Strategy |
When to use |
| bias-detection |
Assess systematic biases in the evidence body — publication bias, reporting bias, and selective outcome reporting. Budget: 40 studies, 40 effect sizes, 40 web searches. |
| cumulative-tracking |
Track evidence accumulation over time — cumulative meta-analysis protocol design. Budget: 40 studies, 40 effect sizes, 30 web searches. |
| heterogeneity-investigation |
Explain why different studies reach different conclusions — heterogeneity investigation protocol. Budget: 30 studies, 30 effect sizes, 50 web searches. |
| network-comparison |
Compare N methods simultaneously including indirect evidence — network meta-analysis protocol design. Budget: 50 studies, 80 effect sizes, 60 web searches. |
| pairwise-synthesis |
Compare two methods across multiple studies — paired meta-analysis protocol design. Budget: 30 studies, 30 effect sizes, 40 web searches. |
Available SOPs
Optional, no fixed order; the final leaf is always a sop.
| SOP |
When to use |
| context-checkpoint |
Append research process and results to the current Phase's context file. Covers both process and results with genuine substance. Use this skill at plan-designated checkpoint points — typically after each strategy completes or at key decision nodes within a research Phase. |
| context-init |
Create a new context file for a research Phase. Called once at Phase start to initialize the file that subsequent context-checkpoint calls will append to. Use this skill whenever a new research Phase begins and a fresh context file is needed. |
1---2name: meta-analysis3description: Cross-Study Statistical Synthesis Campaign — 5 strategies for systematic collection and methodological planning of multi-study evidence synthesis. Covers pairwise, network, cumulative meta-analysis, heterogeneity investigation, and bias detection. Stops at protocol design (no computation).4---56# Meta-Analysis Campaign78Cross-study statistical synthesis — systematic collection and methodological planning for multi-study evidence synthesis. This campaign orchestrates the full meta-analysis planning pipeline from PICO formulation through protocol design, stopping before computation.910## Strategy Routing1112| Trigger | Strategy | When |13|---------|----------|------|14| Two-arm comparison | pairwise-synthesis | Comparing method A vs B across studies |15| Multi-method comparison | network-comparison | Comparing N>=3 methods with indirect evidence |16| Temporal evidence tracking | cumulative-tracking | Tracking how evidence evolves over time |17| Inconsistent findings | heterogeneity-investigation | Studies disagree — explain why |18| Evidence reliability | bias-detection | Assess systematic biases in evidence body |1920## Manifest2122### Strategies (5)2324| Strategy | Purpose |25|----------|---------|26| pairwise-synthesis | Paired meta-analysis protocol for two-method comparison |27| network-comparison | Network meta-analysis for N-method simultaneous comparison |28| cumulative-tracking | Cumulative meta-analysis tracking evidence over time |29| heterogeneity-investigation | Explain inter-study variation in findings |30| bias-detection | Systematic bias assessment of evidence body |3132### Tactics (3)3334| Tactic | Purpose |35|--------|---------|36| effect-size-extraction | Extract effect sizes and conditions from papers |37| quality-assessment-protocol | Methodological quality and bias risk assessment |38| evidence-synthesis-planning | Plan the statistical synthesis approach |3940### Subagent SOPs (10)4142| SOP | Purpose |43|-----|---------|44| pico-formulation | Construct PICO/PECO framework |45| inclusion-criteria-design | Define inclusion/exclusion criteria |46| effect-size-planning | Determine effect size types and calculation methods |47| data-extraction-form | Design structured data extraction form |48| risk-of-bias-assessment | Assess methodological bias (RoB2/PROBAST/QUADAS-2) |49| heterogeneity-source-analysis | Identify and classify heterogeneity sources |50| publication-bias-assessment | Plan funnel plots, Egger's test, trim-and-fill, p-curve |51| sensitivity-analysis-design | Design leave-one-out, influence diagnostics, subgroups |52| evidence-network-construction | Build evidence network graph for NMA |53| meta-analysis-synthesis | Produce final meta-analysis protocol document |5455## Budget Table5657| Strategy | Studies | Effect Sizes | Web Searches |58|----------|---------|--------------|--------------|59| pairwise-synthesis | 30 | 30 | 40 |60| network-comparison | 50 | 80 | 60 |61| cumulative-tracking | 40 | 40 | 30 |62| heterogeneity-investigation | 30 | 30 | 50 |63| bias-detection | 40 | 40 | 40 |6465## MCP Tools6667| MCP Server | Tools |68|------------|-------|69| brave-search | brave_web_search, brave_llm_context |70| apify | rag-web-browser, google-scholar-scraper |71| alphaxiv | get_paper_content, answer_pdf_queries |72| semantic-scholar | ss_relevance_search, ss_paper, ss_references, ss_citations |7374## Context Management7576- **Input**: Research question, domain, candidate studies (optional)77- **State**: Strategy state ledgers track studies found, effect sizes extracted, quality assessed78- **Output**: Complete meta-analysis protocol document (PRISMA-compliant)79- **Persistence**: All intermediate outputs stored in `context/meta-analysis/` subdirectories per strategy8081<!-- BEGIN available-tables (generated) -->8283## Available Strategies8485Optional, no fixed order; the final leaf is always a sop.8687| Strategy | When to use |88| --- | --- |89| bias-detection | Assess systematic biases in the evidence body — publication bias, reporting bias, and selective outcome reporting. Budget: 40 studies, 40 effect sizes, 40 web searches. |90| cumulative-tracking | Track evidence accumulation over time — cumulative meta-analysis protocol design. Budget: 40 studies, 40 effect sizes, 30 web searches. |91| heterogeneity-investigation | Explain why different studies reach different conclusions — heterogeneity investigation protocol. Budget: 30 studies, 30 effect sizes, 50 web searches. |92| network-comparison | Compare N methods simultaneously including indirect evidence — network meta-analysis protocol design. Budget: 50 studies, 80 effect sizes, 60 web searches. |93| pairwise-synthesis | Compare two methods across multiple studies — paired meta-analysis protocol design. Budget: 30 studies, 30 effect sizes, 40 web searches. |9495## Available SOPs9697Optional, no fixed order; the final leaf is always a sop.9899| SOP | When to use |100| --- | --- |101| context-checkpoint | Append research process and results to the current Phase's context file. Covers both process and results with genuine substance. Use this skill at plan-designated checkpoint points — typically after each strategy completes or at key decision nodes within a research Phase. |102| context-init | Create a new context file for a research Phase. Called once at Phase start to initialize the file that subsequent context-checkpoint calls will append to. Use this skill whenever a new research Phase begins and a fresh context file is needed. |103104<!-- END available-tables (generated) -->
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