Risk Of Bias Assessment

Assess methodological bias using RoB2, PROBAST, or QUADAS-2 validated tools

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Risk of Bias Assessment SOP

Conduct structured risk-of-bias assessment for individual studies using the appropriate validated tool (RoB 2.0, ROBINS-I, QUADAS-2, PROBAST, or Newcastle-Ottawa Scale).

When to Use

  • During quality assessment of each included study
  • When deciding sensitivity analysis groupings
  • When assessing GRADE certainty (risk of bias domain)

Input

  • study_metadata: Study characteristics, methods description, and results
  • study_design: The study design (RCT, non-randomized, diagnostic, prediction model, observational)

Output

Domain-level risk-of-bias judgments with supporting rationale for each signaling question.

Available SOPs

Optional, no fixed order; the final leaf is always a sop.

SOP When to use
spawn-agent Spawn a customized CC subagent with full MCP tool access. Used by SOPs that declare execution: subagent.

yogsoth-ai/de-anthropocentric-research-engine/tree/main/skills/risk-of-bias-assessment commit 9a3c6cbee0

Frequently asked questions

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