K-Dense AI

@k-dense-ai source repo

344 skills
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30k repo stars
2 weeks ago last updated

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Pkpd Translation · k-dense-ai bundle
Turn in vitro potency and animal pharmacokinetics into a defensible human dose projection — the arithmetic that decides whether a compound can reach its target concentration safely. Use this skill for non-compartmental analysis of a concentration-time profile (AUC, Cmax, terminal half-life, clearance, volume of distribution), one- and two-compartment simulation of a dosing regimen, interspecies allometric scaling, human-equivalent dose conversion by body surface area, and the exposure margin between a projected therapeutic concentration and a toxicology no-effect level. Also trigger on non-compartmental analysis, AUC, clearance, volume of distribution, allometric scaling, human equivalent dose, first-in-human, NOAEL, therapeutic index, or exposure margin.

30.2k repo stars
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Generative Design · k-dense-ai bundle
Generate and optimise novel small molecules with REINVENT 4 — de novo sampling from a chemical language model, scaffold decoration with LibInvent, fragment linking with LinkInvent, and similarity-constrained analogue generation with Mol2Mol. Use this skill to set up reinforcement-learning or curriculum runs, compose a multi-parameter scoring function from docking scores, predictive models, and physicochemical desirability, and read the resulting sampled sets. Also trigger on REINVENT, LibInvent, LinkInvent, Mol2Mol, scaffold hopping, R-group replacement, linker design, chemical language model, or reinforcement-learning molecule optimisation.

30.2k repo stars
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Antibody Engineering · k-dense-ai bundle
Number antibody variable domains, annotate CDRs, and assess developability from sequence. Use this skill to apply IMGT, Kabat, Chothia, Martin, or AHo numbering with ANARCI, delimit CDRs and framework regions, scan for chemical liabilities (N-glycosylation sequons, deamidation NG, isomerisation DG, oxidation, unpaired cysteine, fragmentation), compute pI, net charge, extinction coefficient and hydrophobicity, and plan humanisation by CDR grafting. Also trigger on antibody, nanobody, VHH, scFv, Fab, CDR, framework, ANARCI, abnumber, IgBLAST, OAS, SAbDab, humanization, Vernier residues, or developability.

30.2k repo stars
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Binding Site Analysis · k-dense-ai bundle
Decide whether a protein has a pocket worth targeting, and where it is, before committing to a docking or design campaign. Use this skill to run fpocket cavity detection, rank cavities by druggability and volume, compare apo and holo conformations to spot induced fit, identify allosteric and cryptic cavities that only open in simulation, and convert a chosen cavity into the search box coordinates a docking run needs. Also trigger on fpocket, cavity detection, druggability score, alpha sphere, cryptic pocket, allosteric site, pocket volume, hotspot mapping, or undruggable target assessment.

30.2k repo stars
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Protein Binder Design · k-dense-ai bundle
Design new proteins that bind a chosen surface, using BindCraft's AlphaFold2-guided hallucination or the RFdiffusion backbone plus ProteinMPNN sequence pipeline. Use this skill to specify a target epitope by hotspot residue, trim a receptor to the region worth designing against, set up a design campaign, and filter the output on the in-silico metrics that predict experimental success — interface predicted TM-score, predicted aligned error at the interface, buried surface area, and shape complementarity. Also trigger on BindCraft, RFdiffusion, ProteinMPNN, minibinder, hallucination, inverse folding, hotspot residue, epitope targeting, ipTM, or de novo binder.

30.2k repo stars
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Free Energy Perturbation · k-dense-ai bundle
Compute relative and absolute binding free energies with the Open Free Energy toolkit — the rigorous alchemical alternative to docking scores when a congeneric series needs reliable potency ranking. Use this skill to plan a perturbation network over a ligand set, choose atom mappings, run hybrid-topology or separated-topology protocols, and analyse the result — per-edge ΔΔG with uncertainty, cycle-closure error, and mean unsigned error against measured affinities. Also trigger on OpenFE, alchemical transformation, thermodynamic cycle, RBFE, ABFE, SepTop, lambda window, MBAR, cycle closure, or perturbation map.

30.2k repo stars
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Terrie E Moffitt · k-dense-ai bundle
Applies the developmental psychopathology and longitudinal research frameworks of Terrie E. Moffitt (psychologist, Duke University). Use this skill whenever reasoning about human development, criminology, juvenile delinquency, self-control, mental health trajectories, or biological aging. Trigger this when asked to evaluate the origins of antisocial behavior, the impact of childhood traits on adult outcomes, the validity of psychiatric diagnoses (comorbidity), or anti-aging interventions. Apply her models to shift focus from cross-sectional snapshots to longitudinal life-course trajectories, emphasizing the 'p' factor, the self-control gradient, and the dual taxonomy of antisocial behavior.

30.2k repo stars
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Virginia M Y Lee · k-dense-ai bundle
Apply this skill whenever evaluating neurodegenerative disease research, protein misfolding, experimental rigor, or career longevity for women in STEM. Use this to channel the thinking of Virginia M.-Y. Lee, neuroscientist at the University of Pennsylvania known for her pioneering work on neurodegeneration. Trigger this skill when discussing Alzheimer's, Parkinson's, ALS, protein aggregation, cell-to-cell transmission of pathology, brain banking, or multidisciplinary scientific collaboration. It is highly relevant when users need critiques on biological models, advice on sustaining a long scientific career, or frameworks for translating clinical pathology into basic science.

30.2k repo stars
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Walter C Willett · k-dense-ai bundle
This skill channels the reasoning of Walter C. Willett, nutrition epidemiologist at Harvard University. Use this skill whenever you are asked to evaluate diets, give nutritional advice, critique food policy, or discuss the environmental impact of food systems. Trigger this skill for topics like macronutrient quality (fats vs. carbs), plant-based diets, the health impacts of red meat or dairy, seed oils, epidemiological methodology, and planetary health. Apply his frameworks to shift focus from macronutrient quantity to quality, evaluate foods using the 'Compared to what?' rule, and prioritize public health over personalized nutrition fads.

30.2k repo stars
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Elizabeth Anscombe · k-dense-ai bundle
Applies the rigorous analytic and moral philosophy of Elizabeth Anscombe (British analytic philosopher, virtue ethics, Intention). Reach for this skill whenever Claude encounters moral dilemmas, ethical trade-offs, questions of intention vs. foresight, or consequentialist/utilitarian reasoning. Use it when analyzing human action, culpability, the doctrine of double effect, or the meaning of "ought" and obligation. It is especially useful for cutting through vague moral language by demanding precise psychological descriptions of actions and rejecting the idea that good ends justify evil means.

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John D Rockefeller · k-dense-ai bundle
Use this skill whenever you need to reason like John D. Rockefeller, founder of Standard Oil and American oil industrialist. Reach for this skill when the user is facing situations involving market consolidation, economies of scale, aggressive cost-cutting, supply chain leverage, or structuring large-scale philanthropy. It is highly applicable for questions about eliminating operational waste, dealing with fierce competition, negotiating from a position of immense scale, or building self-sustaining charitable foundations. Trigger this skill for topics like monopolies, ruthless efficiency, corporate PR crises, and strategic acquisitions, even if the user doesn't explicitly name Rockefeller.

30.2k repo stars
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Simone De Beauvoir · k-dense-ai bundle
Applies the existentialist and feminist philosophy of Simone de Beauvoir, French philosopher and author of The Second Sex. Reach for this skill whenever the user is grappling with existential dilemmas, moral ambiguity, gender dynamics, societal expectations, or relationship ethics. Trigger this skill for questions about freedom versus responsibility, bodily autonomy, marginalization, or when the user feels trapped by external labels or "immanence." Use this to help the user reclaim their agency, recognize the social construction of their situation, and make authentic choices that expand their transcendence while respecting the interconnected freedom of others.

30.2k repo stars
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Whitney Wolfe Herd · k-dense-ai bundle
This skill channels the strategic and empathetic reasoning of Whitney Wolfe Herd, founder and CEO of Bumble. Use this skill whenever you are advising on platform safety, double-sided marketplace dynamics, women's empowerment, purpose-driven entrepreneurship, or overcoming professional trauma. It is highly applicable when users face decisions about product constraints (like time limits or behavioral guardrails), balancing digital engagement with real-world connection, or navigating outdated social dynamics. Reach for this skill to help users shift from 'me to we,' engineer kindness into their products, and focus on core inputs rather than vanity metrics.

30.2k repo stars
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Friedrich Nietzsche · k-dense-ai bundle
Applies the philosophical frameworks of Friedrich Nietzsche (19th-century German philosopher, author of Thus Spoke Zarathustra). Use this skill whenever the user is grappling with existential crises, seeking meaning, facing severe adversity, questioning traditional moral frameworks, or feeling trapped by societal expectations (the "herd"). Trigger this when discussing self-overcoming, creating personal values, analyzing power dynamics in relationships or institutions, dealing with envy, or breaking down dogmatic beliefs. It helps reframe suffering as a catalyst for growth and pushes the user to "become what they are" rather than settling for comfort and mediocrity.

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Hildegard Of Bingen · k-dense-ai bundle
This skill channels the holistic, interconnected reasoning of Hildegard of Bingen, medieval German Benedictine abbess, theologian, and philosopher. Use this skill whenever the user is dealing with ecological stewardship, holistic health, the intersection of spirituality and physical well-being, creative inspiration, or challenging rigid institutional rules with moral clarity. Trigger this when discussing the interconnectedness of systems (microcosm/macrocosm), finding balance and moderation, untwisting destructive habits, or seeking divine/creative inspiration without ego. Apply her frameworks to treat ailments holistically, view music and art as fundamental cosmic forces, and reframe human frailty as a vessel for profound truth.

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Kiran Mazumdar Shaw · k-dense-ai bundle
Applies the strategic thinking of Kiran Mazumdar-Shaw, founder of Biocon and pioneering Indian biopharmaceutical entrepreneur. Use this skill whenever you are advising on biotech startups, R&D innovation, global scaling, purpose-driven business, or navigating regulatory uncertainty. Trigger this skill when discussing affordable healthcare, balancing risk in long-gestation industries, breaking glass ceilings through credible success, or evaluating biotech sovereignty and AI. Reach for this skill even if the user doesn't name her, especially when they face career trade-offs, funding novel scientific ideas, or scaling manufacturing globally.

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Ludwig Wittgenstein · k-dense-ai bundle
Applies the analytical and therapeutic philosophy of Ludwig Wittgenstein, 20th-century philosopher of language (Tractatus / Philosophical Investigations). Use this skill when the user is stuck in conceptual confusion, debating semantics, trapped by abstract definitions, or trying to solve a problem that is actually just a linguistic misunderstanding. Trigger this for topics involving the limits of language, meaning as use, logical clarification, or when the user is over-theorizing instead of looking at practical applications. It helps dissolve 'fly-bottle' traps by examining how words are actually used in context.

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Mary Wollstonecraft · k-dense-ai bundle
Applies the reasoning of Mary Wollstonecraft (18th-century English philosopher and author of A Vindication of the Rights of Woman) to evaluate situations involving power dynamics, education, independence, gender roles, and systemic inequality. Use this skill whenever Claude encounters career trade-offs involving financial dependence, analyzing structural oppression, questioning societal norms, or balancing reason against emotion. It helps dismantle arbitrary hierarchies, prioritize rational capability over superficial elegance, and frame personal struggles as political realities.

30.2k repo stars
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Hypatia Of Alexandria · k-dense-ai bundle
Applies the Neoplatonic and mathematical reasoning of Hypatia of Alexandria. Use this skill whenever the user is grappling with the pursuit of truth, foundational logic, the hierarchy of knowledge, or the distraction of superficial and physical desires versus deeper intellectual pursuits. Trigger this when discussing mathematics as a foundation for higher understanding, astronomy, overcoming base impulses, or seeking the ultimate source of truth. It is highly relevant for questions about rigorous intellectual discipline, esoteric philosophy, and elevating one's mind above material distractions.

30.2k repo stars
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Plato · k-dense-ai bundle
Applies the philosophical frameworks of Plato (ancient Greek philosopher, Theory of Forms, founder of the Academy) to structural, ethical, and epistemological problems. Use this skill whenever the user is grappling with organizational design, leadership ethics, defining abstract concepts, aligning incentives, or uncovering the root essence of a problem. Trigger this when discussing justice, governance, the nature of knowledge, structural harmony, or when a user is trapped by superficial metrics (shadows) and needs to find fundamental truths (Forms). Do not wait for the user to name Plato; proactively apply his dialectical reasoning to cut through illusions.

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Socrates · k-dense-ai bundle
Applies the dialectical reasoning and intellectual humility of Socrates (ancient Greek philosopher, 470-399 BCE). Use this skill whenever the user is grappling with fundamental definitions, moral dilemmas, educational approaches, self-reflection, or making high-stakes ethical decisions. Trigger this skill when encountering topics like virtue, justice, the pursuit of truth, questioning assumptions, coaching, or when the user seems overly confident in unexamined beliefs. It helps dismantle false assumptions through probing questions and redirects focus toward the "care of the soul" and objective truth over external validation or material success.

30.2k repo stars
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Thai Lee · k-dense-ai bundle
Apply the strategic thinking of Thai Lee, CEO of SHI International. Use this skill when the user is navigating bootstrapping vs. venture capital, long-term career sequencing, building an egalitarian corporate culture, or scaling a customer-centric B2B sales organization. Trigger this skill for topics involving decade-by-decade life planning, empowering employees with extreme ownership, or turning personal disadvantages into fuel for preparation. Apply her frameworks whenever these themes arise, even if the user doesn't explicitly name her.

30.2k repo stars
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Aristotle · k-dense-ai bundle
Applies the frameworks of Aristotle (ancient Greek philosopher, logic, ethics, metaphysics, 384-322 BCE) to decision-making, ethics, and analysis. Use this skill whenever the user is grappling with moral dilemmas, character development, habit formation, finding balance (the Golden Mean), persuasive communication (rhetoric), or understanding the root causes and ultimate purpose (teleology) of a project or system. Reach for this skill even if the user doesn't name Aristotle, especially when discussing career fulfillment, long-term happiness (eudaimonia), balancing extremes, or structuring persuasive arguments.

30.2k repo stars
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Confucius · k-dense-ai bundle
Applies the philosophical frameworks of Confucius (ancient Chinese philosopher, 551-479 BCE) to modern problems. Reach for this skill whenever the user is dealing with leadership, governance, team harmony, organizational culture, moral dilemmas, mentorship, or personal self-cultivation. It triggers on topics like building trust without micromanaging, resolving hierarchical conflicts, aligning actions with values, and creating systems based on virtue rather than strict punitive rules. Use this skill to evaluate character, design educational approaches, and foster long-term social harmony.

30.2k repo stars
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Elon Musk · k-dense-ai bundle
This skill applies the first-principles engineering and capital allocation frameworks of Elon Musk (CEO of Tesla and SpaceX, founder of X.com / PayPal). Reach for this skill whenever the user is facing complex manufacturing bottlenecks, evaluating existential risks, debating free speech vs. censorship, dealing with bureaucratic overregulation, or trying to accelerate ambitious technical timelines. It is highly effective for situations involving hardware production, AI symbiosis, radical innovation, and aggressive execution. Use this skill proactively when discussing multi-planetary expansion, government efficiency, or scaling prototypes to mass production, even if the user doesn't explicitly name him.

30.2k repo stars
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Aviv Regev · k-dense-ai bundle
Applies the computational biology and AI-driven reasoning of Aviv Regev (computational biologist, Genentech, single-cell genomics). Use this skill whenever the user is dealing with experimental design, high-dimensional data analysis, integrating AI into scientific workflows, scaling biological research, or navigating noisy, complex systems. Trigger this for topics like single-cell genomics, drug discovery, biological atlases, interdisciplinary research strategy, or when deciding between depth vs. breadth in data collection.

30.2k repo stars
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Bill Gates · k-dense-ai bundle
Apply the mental models of Bill Gates, co-founder of Microsoft and philanthropist. Use this skill whenever you are evaluating climate change solutions, global health interventions, philanthropic resource allocation, software platform economics, or the paradigm-shifting impacts of AI. Trigger this skill when the user is facing decisions about maximizing ROI on charitable giving, assessing clean energy technologies (like calculating the "Green Premium"), building winner-take-all software ecosystems, or using data to drive large-scale institutional progress. Channel his "impatient optimism" to prioritize innovation that multiplies by zero rather than settling for incremental efficiency.

30.2k repo stars
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David Hume · k-dense-ai bundle
Applies the empiricist, skeptical, and practical reasoning of David Hume, 18th-century Scottish philosopher. Use this skill whenever you encounter questions about epistemology, causality, human nature, moral philosophy, political authority, or the limits of rational knowledge. Trigger this skill when the user is grappling with abstract theories that need grounding, evaluating causal claims, discussing the role of emotion vs. reason in decision-making, or questioning the legitimacy of institutions. Even if the user doesn't name Hume, apply his frameworks (like Hume's Fork or the Impression Test) to cut through metaphysical speculation, ground arguments in observable experience, and recognize that reason is ultimately guided by human sentiment.

30.2k repo stars
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Frank B Hu · k-dense-ai bundle
Applies the nutritional epidemiology and public health frameworks of Frank B. Hu (nutrition epidemiologist, Harvard University). Use this skill whenever reasoning about diet quality, public health policy, planetary health, cardiometabolic disease prevention, or evaluating nutritional studies. Trigger this when the user asks about plant-based diets, macronutrient trade-offs ("compared to what?"), the impact of the food environment, or lifestyle factors for longevity. It shifts the AI's focus from single-nutrient reductionism to overall dietary patterns, emphasizing that "zip code is more important than genetic code" and that human health is inextricably linked to planetary health.

30.2k repo stars
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Henry Ford · k-dense-ai bundle
Use this skill whenever reasoning about manufacturing, scaling production, pricing strategies, operational efficiency, vertical integration, or labor compensation. Trigger this skill for situations involving hardware development, supply chain optimization, mass-market economics, or when a founder is deciding between outside investment and bootstrapping. Apply Henry Ford's principles of absolute operational control, continuous manufacturing improvement, and treating efficiency as a service to the consumer. Reach for this whenever a user is building physical products, scaling a business for the 'great multitude', or trying to eliminate operational waste.

30.2k repo stars
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Steve Jobs · k-dense-ai bundle
Applies the product philosophy and leadership frameworks of Steve Jobs, co-founder and CEO of Apple Inc. Reach for this skill whenever the user is navigating product design, customer experience, innovation, hiring top-tier talent, or defining corporate culture. Trigger this skill for questions about finding product-market fit, making career trade-offs, building hardware/software ecosystems, or establishing brand values. Use this to push back against feature creep, committee-driven decisions, and technology-first thinking. Apply Jobs's mental models to help users simplify complex systems, focus on craftsmanship, and build products that sit at the intersection of technology and the liberal arts.

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Zhenan Bao · k-dense-ai bundle
Applies the reasoning, materials design principles, and research philosophy of Zhenan Bao (chemical engineer, Stanford University, flexible electronics). Use this skill whenever you are advising on hardware innovation, materials science, wearable/implantable technology, bioelectronics, or deep-tech research strategy. Trigger this when users face engineering bottlenecks requiring biological inspiration, trade-offs between mechanical and electronic performance, scaling lab fabrication to commercial manufacturing, or managing long-term academic research and mentorship. Apply her frameworks to shift from reactive problem-solving to proactive, integrated design.

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Walt Disney · k-dense-ai bundle
This skill channels the strategic thinking of Walt Disney, co-founder of The Walt Disney Company and animation pioneer. Use this skill whenever you are advising users on creative control, intellectual property, brand building, storytelling, or balancing quality with profit. It is highly effective for situations involving product diversification, media synergy, adapting classic works for mainstream audiences, or designing ambitious, future-proof prototypes (like urban planning or platform ecosystems). Trigger this skill when users face pressure to repeat past successes (sequels), deal with middlemen, or need to elevate a team's creative output through constructive feedback.

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Iris Murdoch · k-dense-ai bundle
Applies the moral philosophy and literary frameworks of Iris Murdoch (British moral philosopher and novelist). Use this skill whenever you are helping a user navigate ethical dilemmas, interpersonal conflicts, creative writing, literary critique, or the struggle against ego and selfishness. Trigger this skill for topics involving moral psychology, the nature of love, attention, objective morality, the separation of philosophy and literature, or overcoming personal fantasy. Murdoch's approach is essential when users are stuck in self-centered thinking, trying to force a decision through sheer willpower, or struggling to see the reality of other people clearly.

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Kay Tee Khaw · k-dense-ai bundle
Use this skill whenever you need to reason about public health, epidemiology, preventive medicine, healthy aging, longevity, lifestyle vs. genetics, or dietary patterns. Kay-Tee Khaw, an epidemiologist at the University of Cambridge, focuses on population health and how modest lifestyle changes impact chronic disease. Trigger this skill when evaluating health interventions, discussing longevity, analyzing real-world health data, or giving advice on diet and lifestyle. Apply her frameworks to shift focus from extreme interventions and isolated nutrients toward whole-food patterns, population-level risk shifts, and the compression of morbidity.

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Mary Midgley · k-dense-ai bundle
Applies the philosophical reasoning of Mary Midgley (British moral philosopher). Use this skill when analyzing ethical dilemmas involving animals, environmental policy, the limits of science (scientism/reductionism), or when users are trapped by unhelpful metaphors (like 'the selfish gene' or 'humans as machines'). Trigger this whenever evaluating the intersection of biology and human nature, resolving irreconcilable viewpoints, or diagnosing systemic conceptual blockages in society or organizations. Midgley's approach emphasizes holism, emotional fellowship, and viewing philosophy as practical 'plumbing' rather than abstract logic.

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Sara Blakely · k-dense-ai bundle
Apply this skill whenever the user is navigating early-stage startups, bootstrapping, product innovation, branding, or overcoming the fear of failure. Sara Blakely, founder of Spanx and self-made billionaire, approaches business by leveraging 'the outsider advantage,' relying on intuition, and obsessing over consumer empathy. Trigger this skill for discussions about funding trade-offs (bootstrapping vs. VC), naming products, dealing with imposter syndrome, entering an industry with zero experience, or building an authentic, vulnerability-driven company culture. Reach for her mental models when users are tempted to share fragile ideas too early, fear embarrassment, or need to rethink how they approach product-market fit.

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Shizuo Akira · k-dense-ai bundle
Use this skill whenever reasoning about immunology, host-pathogen interactions, innate immunity, Toll-like receptors (TLRs), or experimental design in molecular biology. It is also highly relevant for scientific career strategy, particularly when discussing independence, pivoting research domains, or using reverse genetics (like knockout mice) for discovery. Channel Shizuo Akira, immunologist and pioneer of pattern-recognition receptors, to apply rigorous experimental standards (e.g., demanding chemically synthesized mimics over purified extracts) and to view innate immunity as a highly specific, compartmentalized system rather than a primitive defense.

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Albert Hofman · k-dense-ai bundle
Applies the epidemiological reasoning and population-health frameworks of Albert Hofman (Harvard epidemiologist, Rotterdam Study). Trigger this skill whenever you are analyzing public health strategies, preventive medicine, cohort study design, cardiovascular or neurodegenerative disease risks, or healthy aging. Use it when evaluating whether to use population-wide interventions versus individual screening, assessing risk factors in elderly populations, or tracing adult chronic diseases back to early-life or fetal origins.

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Anne Wojcicki · k-dense-ai bundle
Applies the strategic frameworks and mental models of Anne Wojcicki, co-founder and CEO of 23andMe. Reach for this skill when advising on consumer empowerment, navigating heavily regulated industries, preventative healthcare, data privacy, or disrupting entrenched systems. Use this when the user is dealing with misaligned industry incentives, facing regulatory hurdles, building a consumer-research flywheel, or managing a team through a post-launch 'trough of sorrow'. Apply her principles of 'speaking with data', treating users as partners, and pushing for decade-long systemic change from the outside.

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Eric S Lander · k-dense-ai bundle
Use this skill whenever you are reasoning about large-scale scientific projects, genomics, bioethics, data infrastructure, or long-term medical translation. Eric S. Lander (geneticist, Broad Institute, Human Genome Project) provides a framework for hypothesis-free discovery, structuring "big science," and treating biology as an information science. Reach for this when the user is discussing open science, collaborative ecosystems, CRISPR/gene editing ethics, managing massive datasets, or setting realistic timelines for technological breakthroughs. Apply his principles to avoid the "lone genius" myth, prevent overpromising, and build foundational infrastructure that serves the broader community.

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Hannah Arendt · k-dense-ai bundle
This skill channels the reasoning of Hannah Arendt, 20th-century political theorist and author of 'The Origins of Totalitarianism'. Use this skill whenever you are evaluating moral responsibility, analyzing systemic evil, distinguishing between power and violence, or assessing the nature of political action and freedom. Trigger it when discussing bureaucracy, thoughtlessness, the public vs. private realm, truth in politics, or when a user faces unprecedented moral dilemmas requiring 'thinking without a banister'. Apply her frameworks to critique historical determinism, defend factual truth, and analyze human plurality, even if the user does not explicitly name her.

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Immanuel Kant · k-dense-ai bundle
Applies the rigorous deontological ethics, transcendental idealism, and political philosophy of Immanuel Kant (18th-century German philosopher, Critique of Pure Reason). Reach for this skill whenever the user is facing moral dilemmas, questions of duty, truth-telling, evaluating the limits of human knowledge, balancing civic obedience with free speech, or designing systems for global governance and peace. Use this skill to evaluate actions based on universalizability and human dignity rather than consequences, even if the user doesn't explicitly name Kant.

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Judith Butler · k-dense-ai bundle
Use this skill to apply the analytical lens of Judith Butler (American philosopher, gender theory, Gender Trouble). Trigger this skill whenever the user is discussing gender performativity, identity politics, right-wing populism, anti-gender movements, queer theory, bodily autonomy, or the intersection of democracy and marginalized lives. Reach for it when analyzing systemic power, social construction, collective vulnerability, or authoritarian rhetoric. It helps deconstruct essentialist assumptions, reframe anxieties about identity, and build ethical frameworks based on material interdependence rather than mere sympathy.

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Judy Faulkner · k-dense-ai bundle
Applies the reasoning style of Judy Faulkner, founder and CEO of Epic Systems, to decisions around corporate governance, healthcare technology, and unconventional leadership. Use this skill whenever Claude is asked for advice on going public vs. staying private, M&A strategy (acquisitions), budgeting, reducing software-driven burnout, data privacy, or interoperability. Faulkner's thinking is highly independent, fiercely protective of long-term mission over short-term profits, and deeply skeptical of traditional corporate playbooks (like MBAs, strict budgets, and venture capital). Trigger this skill to channel her focus on organic growth, customer empathy, and treating software as 'mental clay'.

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Lynda Resnick · k-dense-ai bundle
This skill channels the strategic marketing and philanthropic reasoning of Lynda Resnick, co-owner of The Wonderful Company, agriculture and consumer brands. Reach for this skill whenever you are advising on transforming commodities into premium brands, identifying a product's Unique Selling Proposition (USP), or designing corporate social responsibility (CSR) and community empowerment programs. Trigger this automatically for queries involving "hands-on philanthropy," "test and roll" marketing, finding intrinsic product value rather than relying on gimmicks, or when a user is navigating the intersection of business leverage and local community investment.

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Marian Ilitch · k-dense-ai bundle
Applies the pragmatic, financially-grounded reasoning of Marian Ilitch (co-founder of Little Caesars Pizza). Use this skill whenever the user is discussing business partnerships, balancing visionary marketing with financial due diligence, franchise unit economics, family business dynamics, or hands-on financial management. Trigger this when users face trade-offs between rapid growth and profitability, need to enforce unit-level accountability, or are paralyzed by the fear of making mistakes. Apply her principles to ground lofty ideas in tactile, common-sense financial reality.

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Oprah Winfrey · k-dense-ai bundle
Applies the reasoning, principles, and mental models of Oprah Winfrey (media mogul, founder of Harpo Productions and OWN network). Use this skill whenever the user is facing career trade-offs, seeking life purpose, struggling with failure or adversity, navigating difficult human connections, or making high-stakes decisions where intuition and intention matter. Trigger this for queries about finding one's calling, overcoming self-doubt, managing personal responsibility, or seeking authentic leadership advice. Channel her focus on intention, inner voice, and turning wounds into wisdom.

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Robert Langer · k-dense-ai bundle
Use this skill when reasoning about deep tech commercialization, biomedical engineering, drug delivery, material design, or overcoming institutional skepticism. Robert Langer, MIT professor and pioneer of drug delivery systems, approaches problems through first-principles engineering, interdisciplinary convergence, and relentless perseverance against consensus. Trigger this skill whenever the user is evaluating high-risk/high-reward research, deciding between incremental vs. paradigm-shifting impact, spinning out academic discoveries into startups, or designing physical/biological systems from scratch. Apply his frameworks to navigate patenting, funding, and translating lab science into real-world impact.

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Thomas Edison · k-dense-ai bundle
Applies the practical, systems-level, and commercially-driven reasoning of Thomas Edison (founder of General Electric, inventor and industrialist). Use this skill whenever the user is navigating product commercialization, systems engineering, R&D strategy, scaling new technologies, evaluating patent decisions, or struggling with repeated iterative failures. Edison's approach shifts the focus from isolated 'genius' inventions to building entire profitable ecosystems, treating failure as a necessary process of elimination, and prioritizing relentless execution over pure theory.

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Joann E Manson · k-dense-ai bundle
Use this skill to reason like JoAnn E. Manson, epidemiologist at Harvard Medical School and women's health expert. Trigger this skill whenever you are evaluating hormone replacement therapy (HRT), menopause management, nutritional epidemiology, dietary supplements, or clinical trial methodology. Apply her frameworks when users ask about the risks and benefits of HRT, bioidentical hormones, or targeted supplementation. Reach for this skill to differentiate between symptom management and chronic disease prevention, or when assessing observational data versus randomized clinical trials (RCTs) in public health contexts.

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Julie E Buring · k-dense-ai bundle
Use this skill to apply the rigorous epidemiological reasoning of Julie E. Buring (epidemiologist and women's health trialist) to study design, clinical trial critiques, cardiovascular risk assessment, and evidence-based integrative medicine. Trigger this skill whenever you are evaluating medical literature, designing cohort studies or RCTs, assessing conflicting research findings, or analyzing cardiovascular risk factors (especially in women). Reach for this when users ask about the validity of supplements, the discrepancy between observational and randomized data, or how to future-proof a clinical registry.

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Rene Descartes · k-dense-ai bundle
Applies the foundationalist reasoning and methodological doubt of René Descartes (17th-century French rationalist philosopher). Use this skill whenever the user is questioning fundamental assumptions, seeking absolute certainty in a decision, dismantling flawed systems, or trying to rebuild a project from first principles. Trigger this skill for topics involving epistemology, rationalism, radical doubt, systemic reconstruction, or separating objective truth from sensory illusion. Reach for this whenever a user needs to cut through probabilities and consensus to find an indubitable 'Archimedean point' to build upon.

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Stacey Gabriel · k-dense-ai bundle
Applies the operational and scientific frameworks of Stacey Gabriel (genomicist and sequencing platform leader at the Broad Institute). Use this skill whenever the user is designing large-scale biomedical research, operationalizing lab workflows, standardizing data governance, or transitioning from bespoke academic experiments to industrial-scale science. It is highly relevant for queries involving genomics, precision medicine, multiomics, cellular perturbation pipelines, or building massive datasets to fuel AI. Trigger this skill to shift the user's focus from 'hand-to-hand combat' one-off studies to systematic, standardized, and scalable data generation.

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Warren Buffett · k-dense-ai bundle
Applies the reasoning, mental models, and capital allocation frameworks of Warren Buffett, CEO of Berkshire Hathaway and value investor. Use this skill whenever the user is evaluating investments, making capital allocation decisions, structuring management and governance, assessing business economics (moats, intrinsic value), navigating market volatility, or making long-term career and partnership choices. Trigger this skill for topics involving value investing, corporate finance, decentralization, and long-term strategic thinking, even if the user doesn't explicitly name Buffett.

30.2k repo stars
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Zhong Lin Wang · k-dense-ai bundle
Applies the reasoning of Zhong Lin Wang (nanotechnology pioneer, Georgia Tech) to problems involving energy harvesting, IoT power scaling, sensor networks, and fundamental physics applications. Reach for this skill whenever the user is discussing self-powered systems, scaling distributed hardware, overcoming battery bottlenecks, or translating fundamental scientific phenomena (like static electricity or mechanical strain) into novel engineering applications. It is highly relevant for hardware roadmapping, optoelectronics, piezotronics, and challenging established scientific assumptions (like classical Maxwell's equations) to model dynamic systems.

30.2k repo stars
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Andrew Carnegie · k-dense-ai bundle
Applies the strategic, philanthropic, and operational frameworks of Andrew Carnegie, founder of Carnegie Steel. Use this skill whenever you are advising on wealth distribution, large-scale philanthropy, operational efficiency, cost control, legacy planning, or organizational leadership. Trigger this skill when users face decisions about charitable giving, managing inherited wealth, optimizing business costs in commodity markets, or structuring trusts and foundations. Apply his ruthless focus on cost-cutting, his belief in empowering self-improvement over direct handouts, and his philosophy that surplus wealth is a public trust.

30.2k repo stars
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Diane Hendricks · k-dense-ai bundle
Reach for this skill whenever Claude encounters situations involving supply chain innovation, B2B customer respect, community revitalization, vocational education, or navigating massive business crises. Apply the mental models of Diane Hendricks, co-founder of ABC Supply and building supplies billionaire, when users face decisions about strategic acquisitions, counter-cyclical expansion, or treating blue-collar workers as respected entrepreneurs. Use this skill to channel her 'fight or fold' resilience, her strict financial responsibility hierarchy, and her focus on solving the exact pain points you faced as a customer.

30.2k repo stars
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Mark Zuckerberg · k-dense-ai bundle
This skill channels the strategic thinking of Mark Zuckerberg, co-founder and CEO of Meta. Reach for this skill whenever the user is navigating rapid product iteration, scaling social platforms, open-source AI strategy, content moderation trade-offs, or long-term organizational management. It is highly effective for scenarios involving "The Hacker Way" (rapid prototyping), building community, handling intense public criticism, or deciding between open vs. closed ecosystems. Use this skill to apply his frameworks on decentralized testing, small group context sharing, and progressive AI integration, even if the user doesn't explicitly mention his name.

30.2k repo stars
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Martha Nussbaum · k-dense-ai bundle
Applies the philosophical frameworks of Martha Nussbaum (American philosopher, capabilities approach, University of Chicago) to evaluate justice, human welfare, and ethical dilemmas. Use this skill whenever the user is discussing measuring societal well-being, educational curricula, animal rights, the role of emotions (like anger or disgust) in law and public life, or navigating human vulnerability and tragedy. Reach for this skill whenever evaluating policy impacts, responding to injustice, or questioning purely economic metrics like GDP. It shifts the focus to what people are actually able to do and be.

30.2k repo stars
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Meir J Stampfer · k-dense-ai bundle
Use this skill whenever you are reasoning about nutritional epidemiology, dietary guidelines, chronic disease prevention, or public health policy. It channels the thinking of Meir J. Stampfer, epidemiologist and nutrition expert at Harvard University. Trigger this skill when evaluating lifestyle factors, comparing observational data versus randomized controlled trials (RCTs), analyzing macronutrient substitutions, or assessing long-term health outcomes. Stampfer's approach is essential when users ask about "good" vs. "bad" foods, seek longevity advice, or need to interpret complex, population-level dietary data without falling for the "magic bullet" fallacy.

30.2k repo stars
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Tamara B Harris · k-dense-ai bundle
Applies the epidemiological and aging research frameworks of Tamara B. Harris (epidemiologist, National Institutes of Health). Use this skill whenever analyzing health metrics in older populations, designing longitudinal studies, evaluating body composition (muscle quality vs. mass), assessing dementia risk factors, or interpreting paradoxical risk factors in geriatrics. Trigger this skill when the user asks about aging, longevity, functional decline, socioeconomic health disparities, or when evaluating clinical trial data where reverse causation or subgroup stratification might skew results.

30.2k repo stars
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Dorret Boomsma · k-dense-ai bundle
Applies the behavioral genetics and twin-study methodologies of Dorret I. Boomsma (behavior geneticist, Vrije Universiteit Amsterdam). Use this skill when reasoning about heritability, genetic epidemiology, nature vs. nurture debates, psychiatric genetics, or longitudinal phenotyping. Trigger this whenever the user asks about the genetic basis of intelligence, lifestyle factors, educational attainment, or psychopathology, or when designing epidemiological studies. It helps deconfound environmental and genetic variables using extended family designs and discordant twin models.

30.2k repo stars
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Graham A Colditz · k-dense-ai bundle
Use this skill whenever you are reasoning about public health policy, cancer prevention, epidemiological study design, clinical risk models, or weight management advice. This skill channels the thinking of Graham A. Colditz, epidemiologist at Washington University in St. Louis. Reach for this when evaluating lifestyle interventions, designing disease prevention programs, critiquing clinical prediction tools (e.g., AUC vs. clinical utility), or analyzing life-course risk accumulation. Apply his frameworks to bridge the "implementation gap" between scientific knowledge and societal action, prioritizing prevention over treatment and attainable weight maintenance over drastic weight loss.

30.2k repo stars
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Martin Heidegger · k-dense-ai bundle
Use this skill to reason like Martin Heidegger, 20th-century German philosopher and author of Being and Time. Reach for this skill whenever you encounter discussions about the existential impact of technology, human meaning-making, mortality, or the limits of purely scientific and data-driven worldviews. Trigger this skill even if the user doesn't name Heidegger, especially when they are trapped in instrumental thinking, treating themselves or others as mere resources, or struggling with authenticity and societal expectations. Apply his frameworks to shift the AI's perspective from detached, objective observation to embedded, practical engagement with the world.

30.2k repo stars
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Ronald C Kessler · k-dense-ai bundle
This skill applies the analytical frameworks of Ronald C. Kessler, psychiatric epidemiologist at Harvard University, to problems in precision psychiatry, clinical trial design, and healthcare machine learning. Use this skill whenever you are designing clinical trials, evaluating mental health interventions, analyzing epidemiological survey data, or building clinical decision support algorithms. It is highly relevant when the user asks about sample sizes, treatment matching, patient attrition, suicide prevention, or predictive modeling in healthcare. Trigger this skill to prioritize massive observational data, tiered predictive models, and human-in-the-loop AI over underpowered randomized trials and expensive, unscalable biomarkers.

30.2k repo stars
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Scientific Writing 2 · k-dense-ai bundle
Draft, revise, and audit scientific manuscripts or reports with explicit evidence provenance, reporting-guideline coverage, authorship accountability, confidentiality controls, and local consistency checks. Use for manuscript sections, references, declarations, tables, figures, or submission preparation when scientific accuracy and traceability matter.

30.2k repo stars
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Citation Management 2 · k-dense-ai bundle
Comprehensive citation management for academic research. Search Google Scholar and PubMed for papers, extract accurate metadata, validate citations, and generate properly formatted BibTeX entries. This skill should be used when you need to find papers, verify citation information, convert DOIs to BibTeX, or ensure reference accuracy in scientific writing.

30.2k repo stars
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Literature Review 3 · k-dense-ai bundle
Conduct comprehensive, systematic literature reviews using multiple academic databases (PubMed, arXiv, bioRxiv, Semantic Scholar, etc.). This skill should be used when conducting systematic literature reviews, meta-analyses, research synthesis, or comprehensive literature searches across biomedical, scientific, and technical domains. Creates professionally formatted markdown documents and PDFs with verified citations in multiple citation styles (APA, Nature, Vancouver, etc.).

30.2k repo stars
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Pytorch Lightning 2 · k-dense-ai bundle
Deep learning framework (PyTorch Lightning / lightning package). Organize PyTorch code into LightningModules, configure Trainers for multi-GPU/TPU, implement data pipelines, callbacks, logging (W&B, TensorBoard, MLflow), distributed training (DDP, FSDP, DeepSpeed), for scalable neural network training.

30.2k repo stars
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Scholar Evaluation 3 · k-dense-ai bundle
Provide qualitative-first, evidence-traceable developmental review of scholarly works and audit low-stakes research-assessment rubrics with optional local quality controls. Never use for ranking people or consequential decisions.

30.2k repo stars
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Statsmodels 2 · k-dense-ai bundle
Statistical models library for Python. Use when you need specific model classes (OLS, GLM, mixed models, ARIMA) with detailed diagnostics, residuals, and inference. Best for econometrics, time series, rigorous inference with coefficient tables. For guided statistical test selection with APA reporting use statistical-analysis.

30.2k repo stars
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Scikit Learn 2 · k-dense-ai bundle
Machine learning in Python with scikit-learn. Use when working with supervised learning (classification, regression), unsupervised learning (clustering, dimensionality reduction), model evaluation, hyperparameter tuning, preprocessing, or building ML pipelines. Provides comprehensive reference documentation for algorithms, preprocessing techniques, pipelines, and best practices.

30.2k repo stars
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Generate Image 2 · k-dense-ai bundle
Generate or edit images with AI models through the OpenRouter Image API (Gemini, FLUX, Seedream, Recraft, GPT-Image). Use for photos, illustrations, artwork, concept art, visual assets, logos, and image editing or compositing from reference images. For flowcharts, circuits, pathways, and other technical diagrams, use the scientific-schematics skill instead.

30.2k repo stars
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Seaborn 2 · k-dense-ai bundle
Statistical visualization with pandas integration. Use for quick exploration of distributions, relationships, and categorical comparisons with attractive defaults. Best for box plots, violin plots, pair plots, heatmaps. Built on matplotlib. For interactive plots use plotly; for publication styling use scientific-visualization.

30.2k repo stars
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Scanpy 2 · k-dense-ai bundle
Standard single-cell RNA-seq analysis pipeline. Use for QC, normalization, dimensionality reduction (PCA/UMAP/t-SNE), clustering, differential expression, visualization, and converting R-friendly single-cell formats such as Seurat or SingleCellExperiment RDS files into h5ad for Scanpy. Best for exploratory scRNA-seq analysis with established workflows. For deep learning models use scvi-tools; for data format questions use anndata.

30.2k repo stars
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Exa Search 4 · k-dense-ai bundle
Web toolkit powered by Exa, tuned for scientific and technical content. Use this skill when the user needs to search the web or fetch/extract URL content. Covers: web search (semantic lookups, research, current info — with optional research-paper category and academic domain filtering) and URL extraction (fetching pages, articles, academic PDFs in batch). Use this skill for web-related tasks when the user wants high-quality search or scholarly filtering via category=research paper. Triggers on requests to search, look up, fetch a page, or extract an article.

30.2k repo stars
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Peer Review 2 · k-dense-ai bundle
Prepare evidence-bounded, constructive peer-review drafts and structured manuscript assessments. Use for authorized review of scientific manuscripts, protocols, preprints, or research proposals; reporting-guideline selection; claim–evidence checks; methods, statistics, reproducibility, ethics, figure/table, and citation critique; or revision-response planning.

30.2k repo stars
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Qiskit 2 · k-dense-ai bundle
Build, simulate, transpile, and execute quantum circuits with Qiskit and IBM Quantum Runtime. Use for Qiskit 2.x circuits and operators, V2 Sampler or Estimator primitives, target-aware transpilation, local or noisy simulation, IBM QPU execution, Runtime sessions or batches, error mitigation, and Qiskit ecosystem packages.

30.2k repo stars
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Claude Scientific Skills · k-dense-ai
Scientific research and analysis skills

30.2k repo stars
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Genomic Coordinates · k-dense-ai bundle
Convert genomic intervals between coordinate conventions, normalise and compare variant representations, and detect assembly or contig-naming mismatches before they corrupt an analysis. Use whenever coordinates cross a format, tool, or assembly boundary - converting between BED, GFF/GTF, VCF, SAM/BAM, WIG, PSL, genePred, Picard interval_list, or region strings; reconciling 0-based half-open with 1-based inclusive; left-aligning or trimming indels; checking whether two variant records describe the same change; mapping genomic to transcript, CDS, or protein positions; auditing a BED/GTF/VCF for convention violations; or diagnosing GRCh37 vs hg19 vs GRCh38 vs T2T, chr-prefix, and liftover problems. Triggers include "off by one", "0-based", "1-based", "half-open", "coordinate system", "left-align", "normalize variant", "bcftools norm", "chr prefix", "wrong genome build", "liftover", "REF mismatch", and "HGVS".

30.2k repo stars
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Genomic Intelligence · k-dense-ai bundle
Predict regulatory features, gene structure, and expression directly from DNA sequence using Genomic Intelligence's hosted transformer DNA language models — no local GPU or model weights. Six tasks over a REST API and a hosted MCP server (keyless public demo): promoter regions, splice donor/acceptor sites, enhancer activity, chromatin state, sequence-to-expression (log TPM), and de-novo gene annotation, plus a composite find-genes-then-predict-expression workflow. Use when the user has a gene symbol, a genomic region, or a DNA/FASTA sequence and wants any of these predictions, mentions Genomic Intelligence, genomicintelligence.ai, api.genomicintelligence.ai, or mcp.genomicintelligence.ai.

30.2k repo stars
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Uncertainty And Units · k-dense-ai bundle
Track physical units and propagate measurement uncertainty in scientific calculations using pint and uncertainties. Use for unit conversion and dimensional checking, GUM uncertainty budgets, Type A and Type B evaluation, coverage factors and expanded uncertainty, Monte Carlo propagation, significant-figure and plus-minus reporting, error propagation through curve fits, CODATA constants, auditing Python code for stripped units or broken uncertainty propagation, and order-of-magnitude plausibility checks using dimensionless groups (Reynolds, Peclet, Damkohler, Knudsen, Biot, Womersley), characteristic scales such as diffusion time or Debye length, and observed magnitude ranges. Trigger on "is this number physically reasonable", "sanity check these units", "what regime is this flow in", or a result that looks off by orders of magnitude.

30.2k repo stars
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Iso Standards Readiness · k-dense-ai bundle
Prepares and structurally reviews readiness evidence for ISO management-system and laboratory-competence standards - ISO 13485 medical device QMS, ISO 14971 device risk management, ISO/IEC 17025 testing and calibration laboratories, and ISO 15189 medical laboratories. Use when organizing declared scope, controlled documents, risk-management files, scope of accreditation, traceability, CAPA, external-provider controls, or bounded local evidence manifests, and when separating ISO certification from laboratory accreditation, FDA QMSR inspection, CLIA certification, MDSAP, and EU MDR/IVDR evidence boundaries. Not for legal applicability, compliance, certification, or accreditation decisions; contains no clause text.

30.2k repo stars
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Ontology Term Resolution · k-dense-ai bundle
Resolve free-text scientific labels to ontology term IDs and validate existing CURIEs against the EBI Ontology Lookup Service (OLS4). Use whenever an ontology identifier must be produced or checked - annotating tissue, cell type, disease, phenotype, assay, chemical, organism, sex, or developmental stage fields; preparing metadata for GEO, ENA, BioSamples, CELLxGENE, HCA, or ISA-Tab submission; auditing a metadata table of term IDs; checking whether a term is obsolete and what replaced it; or mapping between ontologies. Triggers include "ontology term", "ontology ID", "CURIE", "controlled vocabulary", "UBERON", "CL:", "MONDO", "HPO", "EFO", "ChEBI", "NCBITaxon", "GO term", "PATO", "annotate this tissue/cell type/disease", and any request to emit or verify an identifier shaped like PREFIX:0001234.

30.2k repo stars
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Relsa Severity Assessment · k-dense-ai bundle
Multivariate severity assessment and humane endpoint prediction for laboratory animal studies using the RELSA (RELative Severity Assessment) score and ARIMA-based foRcast forecasting. Use when combining welfare readouts — body weight or weight loss, body temperature, clinical or nesting scores, biomarkers, activity, heart rate, burrowing, wheel running — into one severity score per animal per day, when asking which animals are at risk of reaching a humane endpoint or when one will be reached, when defining attention/danger zones or thresholds on a severity scale by kernel density estimation, or when reporting severity for a 3Rs, refinement, animal-welfare, or EU Directive 2010/63/EU severity-assessment context. Covers directionality ("turned" variables), baseline normalization, reference sets, RELSA weights, ARIMA prediction intervals, and RMSE/PICP/MPIW evaluation.

30.2k repo stars
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Analytical Method Validation · k-dense-ai bundle
Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.

30.2k repo stars
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Pathogen Variant Surveillance · k-dense-ai bundle
Query live pathogen genomic surveillance data through the GenSpectrum LAPIS API to find which viral lineages are circulating now, how fast they are growing, and what mutations they carry. Use whenever a question depends on the current state of a pathogen population rather than on remembered facts - which SARS-CoV-2 variant is dominant, whether a Pango lineage is still designated or has been withdrawn, what clade or genotype of H5N1 is in a host or region, whether a PCR primer or assay target still matches circulating sequence, or how a lineage's prevalence has moved week to week. Triggers include "variant surveillance", "genomic surveillance", "what variant is circulating", "dominant variant", "Pango lineage", "lineage prevalence", "growth advantage", "SARS-CoV-2 variant", "XFG", "clade 2.3.4.4b", "H5N1 genotype", "influenza clade", "RSV/mpox/measles/dengue lineage", "CoV-Spectrum", "LAPIS", "Nextclade", "pango-designation", and any request to report what a pathogen population looks like today.

30.2k repo stars
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Waypoint Bio · k-dense-ai bundle
Use when working with Outpost Bio's open microbiome foundation models - the Waypoint checkpoints (Waypoint-6m, Waypoint-45m, Waypoint-170m), the Atlas pretraining corpus, the Compass eight-task benchmark, or the `waypoint` CLI from the `waypoint-bio` package. Covers embedding microbiome samples, fine-tuning on taxonomic abundance data, benchmarking a checkpoint on Compass, pretraining a GPT-2 model on taxonomic abundance profiles, and converting MetaPhlAn, Kraken2, QIIME 2, or MGnify abundance tables into waypoint format.

30.2k repo stars
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Pkpd Modeling · k-dense-ai bundle
Pharmacokinetic and pharmacodynamic modelling and simulation - non-compartmental analysis, compartmental and population PK, PK/PD and exposure-response, TMDD, PBPK orientation, bioequivalence, allometric scaling and first-in-human dose, drug interaction prediction, and Bayesian therapeutic drug monitoring. Use when analysing concentration-time data, deriving exposure metrics, fitting PK or PD models, or evaluating dosing regimens. Triggers include "pharmacokinetics", "pharmacodynamics", "PK/PD", "NCA", "non-compartmental", "AUC", "Cmax", "lambda z", "half-life", "clearance", "volume of distribution", "compartmental model", "population PK", "popPK", "NONMEM", "nlmixr2", "Pharmpy", "Monolix", "exposure-response", "Emax", "EC50", "indirect response", "effect compartment", "TMDD", "PBPK", "bioequivalence", "RSABE", "ABEL", "allometric scaling", "first-in-human", "MABEL", "drug-drug interaction", "DDI", "ICH M12", "concentration-QTc", "therapeutic drug monitoring", "MIPD", and "dosing regimen".

30.2k repo stars
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Lab Hardware Cad · k-dense-ai bundle
Design custom laboratory hardware as parametric build123d models and export fabrication-ready STEP, STL, and DXF files - microfluidic chips and molds, optomechanical mounts and breadboard adapters, cuvette and microplate holders, tube racks, animal-behavior rigs, and 3D-printed instrument fixtures. Use when a research task needs a physical part that must mate with standardized labware, an optical table, a cage system, or a printer, CNC, or laser process.

30.2k repo stars
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Paperclip · k-dense-ai bundle
Search and read full-text biomedical papers, FDA/PMDA/EMA regulatory documents, clinical trial registries, and UniProt/PDB/ChEMBL entries with the Paperclip CLI from GXL. Covers installing and authenticating the `paperclip` binary with a PAPERCLIP_API_KEY, the read-only virtual filesystem under /papers, /fda, /trials, /proteins and /clipboard, source-scoped semantic search, corpus-wide grep, metadata lookup and SQL, map/reduce reading across many papers, figure vision analysis, opt-in paper repositories with claim verification, and line-pinned citations. Use when asked to install paperclip, run paperclip search/grep/map/reduce/sql/repo, find or read biomedical literature, regulatory filings or clinical trials through paperclip, or produce citations with line numbers.

30.2k repo stars
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Deepspot M · k-dense-ai bundle
Generate transcriptome-wide virtual spatial transcriptomics from H&E histology with DeepSpot-M. Use when you need spatial gene expression in log1p-CPM for 224x224 tiles at about 20x, want to query protein-coding genes by symbol instead of a fixed panel, or want to run prediction across a whole slide after tiling with histolab.

30.2k repo stars
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Ncats Arax · k-dense-ai bundle
Queries the NCATS Translator ARAX production API for bounded, typed, provenance-rich one-hop and endpoint-pinned two-hop biomedical knowledge-graph relationships. Use for Biolink-constrained RTX-KG2 lookup, explicit selected-provider ARAX federation, separate entity normalization, qualifier-aware graph traversal, and inspection of TRAPI edge bindings, publications, and knowledge-source provenance. Do not use for inference, ranking, open-ended pathfinding, clinical guidance, or sensitive queries.

30.2k repo stars
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Openpiv · k-dense-ai bundle
Particle Image Velocimetry (PIV) analysis with OpenPIV. Use when extracting velocity fields from PIV image pairs, analyzing fluid dynamics or flow visualization experiments, cross-correlating interrogation windows, validating and replacing spurious PIV vectors, or computing vorticity, strain rate, and turbulence statistics from measured velocity fields.

30.2k repo stars
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Neurokit2 · k-dense-ai bundle
Process and analyze physiological signals including ECG, EEG, EDA, RSP, PPG, EMG, and EOG using Python.

30.2k repo stars
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Optimize For Gpu · k-dense-ai bundle
GPU-accelerate Python code using CuPy, Numba CUDA, Warp, cuDF, cuML, cuGraph, and other RAPIDS libraries for dramatic speedups on numerical, data, ML, graph, and simulation workloads.

30.2k repo stars
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Pytorch Lightning · k-dense-ai bundle
Organize PyTorch code into LightningModules, configure Trainers for multi-GPU/TPU, implement data pipelines, callbacks, logging (W&B, TensorBoard, MLflow), and distributed training (DDP, FSDP, DeepSpeed) for scalable neural network training.

30.2k repo stars
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Scientific Slides · k-dense-ai bundle
Build visually engaging scientific slide decks for conferences, seminars, defenses, and research talks with structured planning, design templates, and automated image generation.

30.2k repo stars
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Stable Baselines3 · k-dense-ai bundle
Train reinforcement learning agents using PPO, SAC, DQN, TD3, DDPG, and A2C algorithms with a scikit-learn-like API. Supports custom Gymnasium environments, vectorized environments, callbacks, and model persistence.

30.2k repo stars

344 published skills · page 2 of 4