Latest Agent Skills

Standard single-cell RNA-seq analysis pipeline. Use for QC, normalization, dimensionality reduction (PCA/UMAP/t-SNE), clustering, differential expression, and visualization. Best for exploratory scRNA-seq analysis with established workflows. For deep learning models use scvi-tools; for data format questions use anndata.

Cloud GPU processing via RunPod serverless. Use when setting up RunPod endpoints, deploying Docker images, managing GPU resources, troubleshooting endpoint issues, or understanding costs. Covers all 5 toolkit images (qwen-edit, realesrgan, propainter, sadtalker, qwen3-tts).

When the user wants help with revenue operations, lead lifecycle management, or marketing-to-sales handoff processes. Also use when the user mentions 'RevOps,' 'revenue operations,' 'lead scoring,' 'lead routing,' 'MQL,' 'SQL,' 'pipeline stages,' 'deal desk,' 'CRM automation,' 'marketing-to-sales handoff,' 'data hygiene,' 'leads aren't getting to sales,' 'pipeline management,' 'lead qualification,' or 'when should marketing hand off to sales.' Use this for anything involving the systems and processes that connect marketing to revenue. For cold outreach emails, see cold-email. For email drip campaigns, see email-sequence. For pricing decisions, see pricing-strategy.

Analyze auto-memory for promotion candidates, stale entries, consolidation opportunities, and health metrics.

Resume a paused experiment. Checkout the experiment branch, read results history, continue iterating.

Generate test report. Use when user says "test report", "results summary", "test status", "show results", "test dashboard", or "how did tests go".

Upload, sync, and manage files across cloud storage providers using rclone. Use when uploading files (images, videos, documents) to S3, Cloudflare R2, Backblaze B2, Google Drive, Dropbox, or any S3-compatible storage. Triggers on "upload to S3", "sync to cloud", "rclone", "backup files", "upload video/image to bucket", or requests to transfer files to remote storage.

IBM quantum computing framework. Use when targeting IBM Quantum hardware, working with Qiskit Runtime for production workloads, or needing IBM optimization tools. Best for IBM hardware execution, quantum error mitigation, and enterprise quantum computing. For Google hardware use cirq; for gradient-based quantum ML use pennylane; for open quantum system simulations use qutip.

Provides Qdrant vector database integration patterns with LangChain4j. Handles embedding storage, similarity search, and vector management for Java applications. Use when implementing vector-based retrieval for RAG systems, semantic search, or recommendation engines.

Python programming patterns and best practices

Fast in-memory DataFrame library for datasets that fit in RAM. Use when pandas is too slow but data still fits in memory. Lazy evaluation, parallel execution, Apache Arrow backend. Best for 1-100GB datasets, ETL pipelines, faster pandas replacement. For larger-than-RAM data use dask or vaex.

Interactive visualization library. Use when you need hover info, zoom, pan, or web-embeddable charts. Best for dashboards, exploratory analysis, and presentations. For static publication figures use matplotlib or scientific-visualization.

Full-featured computational pathology toolkit. Use for advanced WSI analysis including multiplexed immunofluorescence (CODEX, Vectra), nucleus segmentation, tissue graph construction, and ML model training on pathology data. Supports 160+ slide formats. For simple tile extraction from H&E slides, histolab may be simpler.

Provides comprehensive NestJS framework patterns with Drizzle ORM integration. Use when building NestJS applications, setting up APIs, implementing authentication, working with databases, or integrating Drizzle ORM. Covers controllers, providers, modules, middleware, guards, interceptors, testing, microservices, GraphQL, and database patterns.

Mobile development with React Native, Flutter, and native patterns

MATLAB and GNU Octave numerical computing for matrix operations, data analysis, visualization, and scientific computing. Use when writing MATLAB/Octave scripts for linear algebra, signal processing, image processing, differential equations, optimization, statistics, or creating scientific visualizations. Also use when the user needs help with MATLAB syntax, functions, or wants to convert between MATLAB and Python code. Scripts can be executed with MATLAB or the open-source GNU Octave interpreter.

LibAFL is a modular fuzzing library for building custom fuzzers. Use for advanced fuzzing needs, custom mutators, or non-standard fuzzing targets.

This skill should be used when working with genomic interval data (BED files) for machine learning tasks. Use for training region embeddings (Region2Vec, BEDspace), single-cell ATAC-seq analysis (scEmbed), building consensus peaks (universes), or any ML-based analysis of genomic regions. Applies to BED file collections, scATAC-seq data, chromatin accessibility datasets, and region-based genomic feature learning.

Provides Gemini CLI delegation workflows for large-context analysis tasks, including English prompt formulation, execution flags, and safe result handling. Use when the user explicitly asks to use Gemini for a specific task such as broad codebase analysis or long-document processing. Triggers on "use gemini", "delegate to gemini", "run gemini cli", "ask gemini", "use gemini for this task".

Parse FCS (Flow Cytometry Standard) files v2.0-3.1. Extract events as NumPy arrays, read metadata/channels, convert to CSV/DataFrame, for flow cytometry data preprocessing.

Video and audio processing with FFmpeg. Use for format conversion, resizing, compression, audio extraction, and preparing assets for Remotion. Triggers include converting GIF to MP4, resizing video, extracting audio, compressing files, or any media transformation task.

Fetch meetings, transcripts, summaries, and action items from Fathom API. Use when user asks to get Fathom recordings, sync meeting transcripts, or fetch recent calls.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.

Scans a codebase for security vulnerabilities using CodeQL's interprocedural data flow and taint tracking analysis. Triggers on "run codeql", "codeql scan", "codeql analysis", "build codeql database", or "find vulnerabilities with codeql". Supports "run all" (security-and-quality suite) and "important only" (high-precision security findings) scan modes. Also handles creating data extension models and processing CodeQL SARIF output.

When the user wants to optimize content for AI search engines, get cited by LLMs, or appear in AI-generated answers. Also use when the user mentions 'AI SEO,' 'AEO,' 'GEO,' 'LLMO,' 'answer engine optimization,' 'generative engine optimization,' 'LLM optimization,' 'AI Overviews,' 'optimize for ChatGPT,' 'optimize for Perplexity,' 'AI citations,' 'AI visibility,' 'zero-click search,' 'how do I show up in AI answers,' 'LLM mentions,' or 'optimize for Claude/Gemini.' Use this whenever someone wants their content to be cited or surfaced by AI assistants and AI search engines. For traditional technical and on-page SEO audits, see seo-audit. For structured data implementation, see schema-markup.

Use this skill when working with symbolic mathematics in Python. This skill should be used for symbolic computation tasks including solving equations algebraically, performing calculus operations (derivatives, integrals, limits), manipulating algebraic expressions, working with matrices symbolically, physics calculations, number theory problems, geometry computations, and generating executable code from mathematical expressions. Apply this skill when the user needs exact symbolic results rather than numerical approximations, or when working with mathematical formulas that contain variables and parameters.

Swift programming patterns for iOS and macOS

Process-based discrete-event simulation framework in Python. Use this skill when building simulations of systems with processes, queues, resources, and time-based events such as manufacturing systems, service operations, network traffic, logistics, or any system where entities interact with shared resources over time.

Set up a new autoresearch experiment interactively. Collects domain, target file, eval command, metric, direction, and evaluator.

Ruzzy is a coverage-guided Ruby fuzzer by Trail of Bits. Use for fuzzing pure Ruby code and Ruby C extensions.

Cloud-based quantum chemistry platform with Python API. Preferred for computational chemistry workflows including pKa prediction, geometry optimization, conformer searching, molecular property calculations, protein-ligand docking (AutoDock Vina), and AI protein cofolding (Chai-1, Boltz-1/2). Use when tasks involve quantum chemistry calculations, molecular property prediction, DFT or semiempirical methods, neural network potentials (AIMNet2), protein-ligand binding predictions, or automated computational chemistry pipelines. Provides cloud compute resources with no local setup required.

Retro

Cheminformatics toolkit for fine-grained molecular control. SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D generation, similarity, reactions. For standard workflows with simpler interface, use datamol (wrapper around RDKit). Use rdkit for advanced control, custom sanitization, specialized algorithms.

Quantum physics simulation library for open quantum systems. Use when studying master equations, Lindblad dynamics, decoherence, quantum optics, or cavity QED. Best for physics research, open system dynamics, and educational simulations. NOT for circuit-based quantum computing—use qiskit, cirq, or pennylane for quantum algorithms and hardware execution.

Therapeutics Data Commons. AI-ready drug discovery datasets (ADME, toxicity, DTI), benchmarks, scaffold splits, molecular oracles, for therapeutic ML and pharmacological prediction.

Genomic file toolkit. Read/write SAM/BAM/CRAM alignments, VCF/BCF variants, FASTA/FASTQ sequences, extract regions, calculate coverage, for NGS data processing pipelines.

Multi-objective optimization framework. NSGA-II, NSGA-III, MOEA/D, Pareto fronts, constraint handling, benchmarks (ZDT, DTLZ), for engineering design and optimization problems.

Run Python code in the cloud with serverless containers, GPUs, and autoscaling. Use when deploying ML models, running batch processing jobs, scheduling compute-intensive tasks, or serving APIs that require GPU acceleration or dynamic scaling.

High-performance toolkit for genomic interval analysis in Rust with Python bindings. Use when working with genomic regions, BED files, coverage tracks, overlap detection, tokenization for ML models, or fragment analysis in computational genomics and machine learning applications.

This skill should be used when searching, fetching, or downloading emails from Gmail. Use for queries like "search Gmail for...", "find emails from John", "show unread emails", "emails about project X", or "download attachment from email".

Flame Engine 2D 遊戲開發完整指南 - 核心、系統、模板、部署

Provides Codex CLI delegation workflows for complex code generation and development tasks using OpenAI's GPT-5.3-codex models, including English prompt formulation, execution flags, sandbox modes, and safe result handling. Use when the user explicitly asks to use Codex for complex programming tasks such as code generation, refactoring, or architectural analysis. Triggers on "use codex", "delegate to codex", "run codex cli", "ask codex", "codex exec", "codex review".

AFL++ is a fork of AFL with better fuzzing performance and advanced features. Use for multi-core fuzzing of C/C++ projects.

Create and manage Zoom meetings and access cloud recordings via the Zoom API. Use for queries like "create a Zoom meeting", "list my Zoom meetings", "show my Zoom recordings", or "schedule a meeting for tomorrow".

Comprehensive spreadsheet creation, editing, and analysis with support for formulas, formatting, data analysis, and visualization. When Claude needs to work with spreadsheets (.xlsx, .xlsm, .csv, .tsv, etc) for: (1) Creating new spreadsheets with formulas and formatting, (2) Reading or analyzing data, (3) Modify existing spreadsheets while preserving formulas, (4) Data analysis and visualization in spreadsheets, or (5) Recalculating formulas

Use this skill for processing and analyzing large tabular datasets (billions of rows) that exceed available RAM. Vaex excels at out-of-core DataFrame operations, lazy evaluation, fast aggregations, efficient visualization of big data, and machine learning on large datasets. Apply when users need to work with large CSV/HDF5/Arrow/Parquet files, perform fast statistics on massive datasets, create visualizations of big data, or build ML pipelines that do not fit in memory.

Model interpretability and explainability using SHAP (SHapley Additive exPlanations). Use this skill when explaining machine learning model predictions, computing feature importance, generating SHAP plots (waterfall, beeswarm, bar, scatter, force, heatmap), debugging models, analyzing model bias or fairness, comparing models, or implementing explainable AI. Works with tree-based models (XGBoost, LightGBM, Random Forest), deep learning (TensorFlow, PyTorch), linear models, and any black-box model.

Rust programming patterns and ownership concepts

Ruby programming patterns and idioms

Rice

Bayesian modeling with PyMC. Build hierarchical models, MCMC (NUTS), variational inference, LOO/WAIC comparison, posterior checks, for probabilistic programming and inference.

Presentation creation, editing, and analysis. When Claude needs to work with presentations (.pptx files) for: (1) Creating new presentations, (2) Modifying or editing content, (3) Working with layouts, (4) Adding comments or speaker notes, or any other presentation tasks

Execute Claude Code commands in the telegram_agent project directory. Use when the user wants to work on the telegram agent itself, fix bugs, add features, or modify the bot code. This is a COMMAND HANDLER, not a script executor.

Start an autonomous experiment loop with user-selected interval (10min, 1h, daily, weekly, monthly). Uses CronCreate for scheduling.

Use this agent when you need to run linting and code quality checks on Ruby and ERB files. Run before pushing to origin.

Set up Playwright in a project. Use when user says "set up playwright", "add e2e tests", "configure playwright", "testing setup", "init playwright", or "add test infrastructure".

Fast CLI/Python queries to 20+ bioinformatics databases. Use for quick lookups: gene info, BLAST searches, AlphaFold structures, enrichment analysis. Best for interactive exploration, simple queries. For batch processing or advanced BLAST use biopython; for multi-database Python workflows use bioservices.

Comprehensive document creation, editing, and analysis with support for tracked changes, comments, formatting preservation, and text extraction. When Claude needs to work with professional documents (.docx files) for: (1) Creating new documents, (2) Modifying or editing content, (3) Working with tracked changes, (4) Adding comments, or any other document tasks

Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code beyond memory or across clusters. Best for parallel file processing, distributed ML, integration with existing pandas code. For out-of-core analytics on single machine use vaex; for in-memory speed use polars.

Google quantum computing framework. Use when targeting Google Quantum AI hardware, designing noise-aware circuits, or running quantum characterization experiments. Best for Google hardware, noise modeling, and low-level circuit design. For IBM hardware use qiskit; for quantum ML with autodiff use pennylane; for physics simulations use qutip.