Latest Agent Skills

Molecular machine learning toolkit. Property prediction (ADMET, toxicity), GNNs (GCN, MPNN), MoleculeNet benchmarks, pretrained models, featurization, for drug discovery ML.

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Query, stage, and apply configuration changes for Railway environments. Use for ANY variable or env var operations, service configuration (source, build settings, deploy settings), lifecycle (delete service), and applying changes. Prefer over railway-status skill for any configuration or variable queries.

Implements the NOWAIT technique for efficient reasoning in R1-style LLMs. Use when optimizing inference of reasoning models (QwQ, DeepSeek-R1, Phi4-Reasoning, Qwen3, Kimi-VL, QvQ), reducing chain-of-thought token usage by 27-51% while preserving accuracy. Triggers on "optimize reasoning", "reduce thinking tokens", "efficient inference", "suppress reflection tokens", or when working with verbose CoT outputs.

Manage issues, projects & team workflows in Linear. Use when the user wants to read, create or updates tickets in Linear.

Guide for continuous improvement, error proofing, and standardization. Use this skill when the user wants to improve code quality, refactor, or discuss process improvements.

Server-side JavaScript hooks for PocketBase (pb_hooks). Use when writing custom routes, event hooks, cron jobs, sending emails, making HTTP requests, querying the database, or extending PocketBase with server-side logic. Covers the goja ES5 runtime, routing, middleware, all event hooks, DB queries, record operations, and global APIs.

Write idiomatic PHP code with generators, iterators, SPL data structures, and modern OOP features. Use PROACTIVELY for high-performance PHP applications.

GraphQL gives clients exactly the data they need - no more, no less. One endpoint, typed schema, introspection. But the flexibility that makes it powerful also makes it dangerous. Without proper controls, clients can craft queries that bring down your server. This skill covers schema design, resolvers, DataLoader for N+1 prevention, federation for microservices, and client integration with Apollo/urql. Key insight: GraphQL is a contract. The schema is the API documentation. Design it carefully.

Write idiomatic C++ code with modern features, RAII, smart pointers, and STL algorithms. Handles templates, move semantics, and performance optimization.

Modern Angular (v20+) expert with deep knowledge of Signals, Standalone Components, Zoneless applications, SSR/Hydration, and reactive patterns.

Guides and best practices for working with Neon Serverless Postgres. Covers getting started, local development with Neon, choosing a connection method, Neon features, authentication (@neondatabase/auth), PostgREST-style data API (@neondatabase/neon-js), Neon CLI, and Neon's Platform API/SDKs. Use for any Neon-related questions.

Design a PostgreSQL-specific schema. Covers best-practices, data types, indexing, constraints, performance patterns, and advanced features

LLM Operations -- RAG, embeddings, vector databases, fine-tuning, prompt engineering avancado, custos de LLM, evals de qualidade e arquiteturas de IA para producao.

Creates detailed, sectionized implementation plans through research, stakeholder interviews, and multi-LLM review. Use when planning features that need thorough pre-implementation analysis.

Create and manage persistent markdown planning files for structured task execution. Use when the user asks to "create a plan", "track progress", "start a research project", or when a task requires more than 5 tool calls and needs structured phase tracking to stay focused and avoid goal drift.

Crawl entire websites using Cloudflare Browser Rendering /crawl API. Initiates async crawl jobs, polls for completion, and saves results as markdown files. Useful for ingesting documentation sites, knowledge bases, or any web content into your project context. Requires CLOUDFLARE_ACCOUNT_ID and CLOUDFLARE_API_TOKEN environment variables.

Perform code reviews following Sentry engineering practices. Use when reviewing pull requests, examining code changes, or providing feedback on code quality. Covers security, performance, testing, and design review.

Statistical visualization. Scatter, box, violin, heatmaps, pair plots, regression, correlation matrices, KDE, faceted plots, for exploratory analysis and publication figures.

Python library for working with DICOM (Digital Imaging and Communications in Medicine) files. Use this skill when reading, writing, or modifying medical imaging data in DICOM format, extracting pixel data from medical images (CT, MRI, X-ray, ultrasound), anonymizing DICOM files, working with DICOM metadata and tags, converting DICOM images to other formats, handling compressed DICOM data, or processing medical imaging datasets. Applies to tasks involving medical image analysis, PACS systems, radiology workflows, and healthcare imaging applications.

Molecular featurization for ML (100+ featurizers). ECFP, MACCS, descriptors, pretrained models (ChemBERTa), convert SMILES to features, for QSAR and molecular ML.

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.

Mass spectrometry analysis. Process mzML/MGF/MSP, spectral similarity (cosine, modified cosine), metadata harmonization, compound ID, for metabolomics and MS data processing.

This skill should be used when working with LaminDB, an open-source data framework for biology that makes data queryable, traceable, reproducible, and FAIR. Use when managing biological datasets (scRNA-seq, spatial, flow cytometry, etc.), tracking computational workflows, curating and validating data with biological ontologies, building data lakehouses, or ensuring data lineage and reproducibility in biological research. Covers data management, annotation, ontologies (genes, cell types, diseases, tissues), schema validation, integrations with workflow managers (Nextflow, Snakemake) and MLOps platforms (W&B, MLflow), and deployment strategies.

Multiagent AI system for scientific research assistance that automates research workflows from data analysis to publication. This skill should be used when generating research ideas from datasets, developing research methodologies, executing computational experiments, performing literature searches, or generating publication-ready papers in LaTeX format. Supports end-to-end research pipelines with customizable agent orchestration.

Pythonic wrapper around RDKit with simplified interface and sensible defaults. Preferred for standard drug discovery: SMILES parsing, standardization, descriptors, fingerprints, clustering, 3D conformers, parallel processing. Returns native rdkit.Chem.Mol objects. For advanced control or custom parameters, use rdkit directly.

Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.

Comprehensive Python library for astronomy and astrophysics. This skill should be used when working with astronomical data including celestial coordinates, physical units, FITS files, cosmological calculations, time systems, tables, world coordinate systems (WCS), and astronomical data analysis. Use when tasks involve coordinate transformations, unit conversions, FITS file manipulation, cosmological distance calculations, time scale conversions, or astronomical data processing.

This skill should be used when working with annotated data matrices in Python, particularly for single-cell genomics analysis, managing experimental measurements with metadata, or handling large-scale biological datasets. Use when tasks involve AnnData objects, h5ad files, single-cell RNA-seq data, or integration with scanpy/scverse tools.

Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.

Manage Railway deployments - view logs, redeploy, restart, or remove deployments. Use for deployment lifecycle (remove, stop, redeploy, restart), deployment visibility (list, status, history), and troubleshooting (logs, errors, failures, crashes). NOT for deleting services - use railway-environment skill with isDeleted for that.

Reviews a product document (PRD, spec, design brief) BEFORE implementation to surface holes — undefined edge cases, missing states, policy gaps — by attacking what the document is SILENT about (things unwritten, and things written only for the happy path). Acts as a strict "sign-off manager," ruling Approve / Conditional / Reject and producing a polite, forwardable question list. Works for planners/PMs (self-review before sharing), engineers (blocking questions before coding), and designers (screen states with no mockup). Use whenever the user wants a spec/PRD/plan/brief checked for readiness or gaps, or says "review this spec", "find holes in this PRD", "poke holes in this", "is this plan good to build?", "can I start implementing this?", "what states/edge cases am I missing?", "what should I ask the PM before coding?", "run devil", or pastes/links a planning document and asks whether it's ready to act on. Do NOT use it to: write or draft a new spec, summarize or translate a document, estimate/break down tic

Convex reactive backend expert: schema design, TypeScript functions, real-time subscriptions, auth, file storage, scheduling, and deployment.

Use when the user asks to run Gemini CLI for code review, plan review, or big context (>200k) processing. Ideal for comprehensive analysis requiring large context windows. Uses Gemini 3 Pro by default for state-of-the-art reasoning and coding.

Expert in CrewAI - the leading role-based multi-agent framework used by 60% of Fortune 500 companies. Covers agent design with roles and goals, task definition, crew orchestration, process types (sequential, hierarchical, parallel), memory systems, and flows for complex workflows. Essential for building collaborative AI agent teams. Use when: crewai, multi-agent team, agent roles, crew of agents, role-based agents.

Iterate on a PR until CI passes. Use when you need to fix CI failures, address review feedback, or continuously push fixes until all checks are green. Automates the feedback-fix-push-wait cycle.

Single-cell RNA-seq analysis. Load .h5ad/10X data, QC, normalization, PCA/UMAP/t-SNE, Leiden clustering, marker genes, cell type annotation, trajectory, for scRNA-seq analysis.

Comprehensive quantum computing toolkit for building, optimizing, and executing quantum circuits. Use when working with quantum algorithms, simulations, or quantum hardware including (1) Building quantum circuits with gates and measurements, (2) Running quantum algorithms (VQE, QAOA, Grover), (3) Transpiling/optimizing circuits for hardware, (4) Executing on IBM Quantum or other providers, (5) Quantum chemistry and materials science, (6) Quantum machine learning, (7) Visualizing circuits and results, or (8) Any quantum computing development task.

Fast DataFrame library (Apache Arrow). Select, filter, group_by, joins, lazy evaluation, CSV/Parquet I/O, expression API, for high-performance data analysis workflows.

Interactive scientific and statistical data visualization library for Python. Use when creating charts, plots, or visualizations including scatter plots, line charts, bar charts, heatmaps, 3D plots, geographic maps, statistical distributions, financial charts, and dashboards. Supports both quick visualizations (Plotly Express) and fine-grained customization (graph objects). Outputs interactive HTML or static images (PNG, PDF, SVG).

Computational pathology toolkit for analyzing whole-slide images (WSI) and multiparametric imaging data. Use this skill when working with histopathology slides, H&E stained images, multiplex immunofluorescence (CODEX, Vectra), spatial proteomics, nucleus detection/segmentation, tissue graph construction, or training ML models on pathology data. Supports 160+ slide formats including Aperio SVS, NDPI, DICOM, OME-TIFF for digital pathology workflows.

This skill should be used when working with genomic interval data (BED files) for machine learning tasks. Use for training region embeddings (Region2Vec, BEDspace), single-cell ATAC-seq analysis (scEmbed), building consensus peaks (universes), or any ML-based analysis of genomic regions. Applies to BED file collections, scATAC-seq data, chromatin accessibility datasets, and region-based genomic feature learning.

Parse FCS (Flow Cytometry Standard) files v2.0-3.1. Extract events as NumPy arrays, read metadata/channels, convert to CSV/DataFrame, for flow cytometry data preprocessing.

Autonomous biomedical AI agent framework for executing complex research tasks across genomics, drug discovery, molecular biology, and clinical analysis. Use this skill when conducting multi-step biomedical research including CRISPR screening design, single-cell RNA-seq analysis, ADMET prediction, GWAS interpretation, rare disease diagnosis, or lab protocol optimization. Leverages LLM reasoning with code execution and integrated biomedical databases.

Search and deploy services from Railway's template marketplace. Use when user wants to add a service from a template, find templates for a specific use case, or deploy tools like Ghost, Strapi, n8n, Minio, Uptime Kuma, etc. For databases (Postgres, Redis, MySQL, MongoDB), prefer the railway-database skill.

JavaScript SDK usage for PocketBase client applications. Use when calling PocketBase from frontend or Node.js, authenticating users, subscribing to realtime events, uploading files, or working with the PocketBase JS/TS SDK. Covers CRUD, auth flows, authStore, realtime SSE, file handling, batch operations, and query syntax.

Use when the user asks to run Codex CLI (codex exec, codex resume) or references OpenAI Codex for code analysis, refactoring, or automated editing. Uses GPT-5.2 by default for state-of-the-art software engineering.

Write efficient C code with proper memory management, pointer

Find bugs, security vulnerabilities, and code quality issues in local branch changes. Use when asked to review changes, find bugs, security review, or audit code on the current branch.

Create pull requests following Sentry conventions. Use when opening PRs, writing PR descriptions, or preparing changes for review. Follows Sentry's code review guidelines.

Use this skill when working with symbolic mathematics in Python. This skill should be used for symbolic computation tasks including solving equations algebraically, performing calculus operations (derivatives, integrals, limits), manipulating algebraic expressions, working with matrices symbolically, physics calculations, number theory problems, geometry computations, and generating executable code from mathematical expressions. Apply this skill when the user needs exact symbolic results rather than numerical approximations, or when working with mathematical formulas that contain variables and parameters.

Process-based discrete-event simulation framework in Python. Use this skill when building simulations of systems with processes, queues, resources, and time-based events such as manufacturing systems, service operations, network traffic, logistics, or any system where entities interact with shared resources over time.

Cheminformatics toolkit for fine-grained molecular control. SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D generation, similarity, reactions. For standard workflows with simpler interface, use datamol (wrapper around RDKit). Use rdkit for advanced control, custom sanitization, specialized algorithms.

Quantum mechanics simulations and analysis using QuTiP (Quantum Toolbox in Python). Use when working with quantum systems including: (1) quantum states (kets, bras, density matrices), (2) quantum operators and gates, (3) time evolution and dynamics (Schrödinger, master equations, Monte Carlo), (4) open quantum systems with dissipation, (5) quantum measurements and entanglement, (6) visualization (Bloch sphere, Wigner functions), (7) steady states and correlation functions, or (8) advanced methods (Floquet theory, HEOM, stochastic solvers). Handles both closed and open quantum systems across various domains including quantum optics, quantum computing, and condensed matter physics.

Therapeutics Data Commons. AI-ready drug discovery datasets (ADME, toxicity, DTI), benchmarks, scaffold splits, molecular oracles, for therapeutic ML and pharmacological prediction.

Genomic file toolkit. Read/write SAM/BAM/CRAM alignments, VCF/BCF variants, FASTA/FASTQ sequences, extract regions, calculate coverage, for NGS data processing pipelines.

Multi-objective optimization framework. NSGA-II, NSGA-III, MOEA/D, Pareto fronts, constraint handling, benchmarks (ZDT, DTLZ), for engineering design and optimization problems.

Run Python code in the cloud with serverless containers, GPUs, and autoscaling. Use when deploying ML models, running batch processing jobs, scheduling compute-intensive tasks, or serving APIs that require GPU acceleration or dynamic scaling.

High-performance toolkit for genomic interval analysis in Rust with Python bindings. Use when working with genomic regions, BED files, coverage tracks, overlap detection, tokenization for ML models, or fragment analysis in computational genomics and machine learning applications.

List, switch, and configure Railway projects. Use when user wants to list all projects, switch projects, rename a project, enable/disable PR deploys, make a project public/private, or modify project settings.