Product & Planning

lyndonkl Bundle

Designs structured interview guides, survey instruments, and JTBD probes to learn from users while avoiding common research biases (leading questions, confirmation bias, selection bias). Use when validating product assumptions before building, discovering unmet user needs, understanding customer problems and workflows, testing concepts or positioning, researching target markets, identifying jobs-to-be-done and hiring triggers, or uncovering pain points and workarounds.

lyndonkl Bundle

Creates explicit stakeholder alignment through negotiated working agreements, clear decision rights (RACI/DACI/RAPID), and conflict resolution protocols. Use when stakeholders need aligned working agreements, resolving decision authority ambiguity, navigating cross-functional conflicts, establishing governance frameworks, negotiating resource allocation, defining escalation paths, creating team norms, mediating trade-off disputes, or when user mentions stakeholder alignment, decision rights, working agreements, conflict resolution, governance model, or consensus building.

lyndonkl Bundle

Guides collaborative discovery of hidden symmetries in ML data through structured domain analysis, coordinate system examination, transformation testing, and physical constraint identification. No group theory knowledge required. Use when ML engineers need to identify symmetries in their data, when user mentions data symmetry, invariance discovery, what transformations matter, or needs help recognizing patterns their model should respect.

lyndonkl Bundle

Chains estimation, decision analysis, and storytelling to transform uncertain choices into clear, stakeholder-ready recommendations. Quantifies uncertain variables, applies expected value analysis to identify the best option, then packages the analysis into a persuasive narrative. Use when evaluating strategic options (build vs buy, market entry, resource allocation), quantifying tradeoffs, justifying investments, pitching to decision-makers, or when user mentions ROI analysis, expected value, business case, cost-benefit, or needs to combine estimation with persuasive communication.

rysweet Bundle

Aspire orchestration for cloud-native distributed applications in any language (C#, Python, Node.js, Go). Handles dependency management, local dev with Docker, Azure deployment, service discovery, and observability dashboards. Use when setting up microservices, containerized apps, or polyglot distributed systems.

rysweet Bundle

Expert project manager orchestrating backlog-curator, work-delegator, workstream-coordinator, and roadmap-strategist sub-skills. Coordinates complex software projects through delegation and strategic oversight. Activates when managing projects, coordinating work, or tracking overall progress.

thelobbi Skill

Jira project management including issues, sprints, boards, and workflows. Activate for Jira tickets, sprint planning, backlog management, and Atlassian integration.

thelobbi Skill

.NET Aspire for cloud-native app orchestration, service discovery, telemetry, and component integrations

thelobbi Skill

This skill should be used when designing the tool surface behind an agent UI — action-oriented naming, descriptions that drive correct model selection, input and output schemas, structuredContent vs content vs _meta, safety annotations, tool visibility, and the discovery metadata that decides whether the app ever gets invoked.

thelobbi Skill

This skill should be used when shipping an MCP app into Microsoft 365 Copilot as a declarative agent — prerequisites, the widget host CORS URL, OAuth 2.1 and Entra SSO redirect URIs, Agents Toolkit sideloading, dynamic tool discovery, and the Copilot-specific capability gaps to design around.

thelobbi Skill

This skill should be used when running many parallel coding agents against a Linear backlog — conductor/worker dispatch, exclusive claims, workspace isolation, retry and stall handling. Activates on "swarm", "parallel agents", "conductor", "fan out issues", "symphony", "worktree isolation", "delegation ledger".

mims-harvard Bundle

Comprehensive drug-target intelligence — tissue expression (GTEx, HPA), pathways, protein interactions (STRING), variant landscape (ClinVar, gnomAD), druggability (DGIdb, ChEMBL approved drugs). 9 parallel research paths with citations. Use for full target profile reports, target characterization for drug discovery, and 'tell me about target X' queries.

mims-harvard Skill

Aging biology, cellular senescence, and longevity research. Covers senescence markers (p16/CDKN2A, SASP, SA-beta-gal), aging hallmarks, senolytic drug discovery (dasatinib+quercetin, fisetin, navitoclax), epigenetic clocks, telomere biology, and longevity GWAS. Use for senescence-pathway analysis, age-related disease genetics, senolytic-target discovery, and centenarian-genetics queries. Distinguishes correlative vs causal evidence (knockout, intervention).

mims-harvard Bundle

Discover novel small-molecule binders for protein targets using structure-based and ligand-based screening. Covers druggability assessment, known-ligand mining (ChEMBL, BindingDB), similarity expansion, ADMET filtering, and synthesis feasibility. Use for hit identification, virtual screening, target-to-compounds workflows, and lead-finding before commit-to-medchem.

mims-harvard Skill

Find and evaluate research datasets for any scientific question. Maps research questions to required study designs (longitudinal vs cross-sectional, observational vs experimental, single-cohort vs multi-cohort). Use when the user asks 'find data about X', 'where can I get data on Y', or needs a specific cohort/survey/repository. Covers GEO, ArrayExpress, dbGaP, NHANES, UK Biobank, ClinicalTrials.gov, GWAS Catalog, and 30+ scientific repositories.

mims-harvard Skill

KEGG-based disease-drug-variant network research. Connects diseases to causal genes, drugs to molecular targets, and variants to pathways using KEGG's editorially curated databases (KEGG Disease, Drug, Network, Variant, Pathway). Use for drug repurposing via shared pathways, mechanistic disease-gene-drug networks, and pathway-based target discovery. Distinguishes direct (binding) vs indirect (pathway co-membership) drug-target relationships.

mims-harvard Bundle

Biological sequence analysis — gene/protein sequence retrieval (NCBI, Ensembl, UniProt), nucleotide/protein search, ortholog discovery, and FASTQ QC + alignment workflows (Trimmomatic, BWA, samtools, coverage depth). Use for sequence retrieval, sequence comparison, FASTQ QC analysis, and read alignment pre-processing.

mims-harvard Bundle

Transform GWAS signals into drug targets and repurposing opportunities. Connects GWAS-significant loci to causal genes via fine-mapping/eQTL, then to druggable proteins via DGIdb/OpenTargets, then to existing drugs via ChEMBL. Use for GWAS-to-target hypothesis generation, druggable-fraction analysis of disease loci, and human-genetics-validated drug-repurposing prioritization.

mims-harvard Skill

Microbiome research using MGnify, GTDB, ENA, OLS (ENVO biomes), and EuropePMC. Covers study discovery, taxonomic profiling, host-microbe interaction analysis, and biome-by-condition queries. Use for microbiome study selection, organism-environment associations, and clinical-microbiome literature review. Distinct from analytical workflow (use tooluniverse-metagenomics-analysis for that).

mims-harvard Skill

TCGA/GDC cancer genomics analysis — cohort construction, clinical metadata retrieval, somatic mutation frequencies, survival analysis, and multi-omics integration. Use for TCGA-BRCA-style cohort studies, mutation prevalence by cancer type, survival-by-mutation analysis, and pan-cancer driver discovery. Always cancer-type-specific (don't use pan-cancer counts without cohort context).

mims-harvard Bundle

Compound-target-disease network construction and analysis for drug repurposing, polypharmacology discovery, and multi-target drug design. Uses STRING, BioGRID, ChEMBL, DGIdb, OMIM, OpenTargets. Use for off-target effect prediction, network-based drug repurposing, and identifying molecules with desired multi-target profile.

mims-harvard Skill

Histone-modification ChIP-seq, ATAC-seq accessibility, chromatin state, and TF binding analysis from ENCODE, Roadmap Epigenomics, ChIP-Atlas. Use for chromatin-state-by-tissue queries, TF-binding-by-region, regulatory landscape mapping, and ENCODE-cCRE annotations. For DNA methylation use tooluniverse-epigenomics; for RNA-seq use tooluniverse-rnaseq-deseq2.

mims-harvard Bundle

Analyze NIH grant portfolios and funding history using the OpenNIH FY1985-present corpus, then connect grants to investigators, institutions, publications, clinical trials, patents, targets, or drugs with ToolUniverse. Use for NIH grant discovery, topic or Institute/Center trends, PI and institution profiles, activity-code or mechanism analysis, funding growth and concentration, grant-writing landscape research, SBIR/STTR landscapes, research-policy analysis, expert discovery, funding-to-output translational impact studies, or public-facing NIH explainers for patients, advocates, local and national journalists, trainees, applicants, institutions, entrepreneurs, and taxpayers.

mims-harvard Skill

Rare disease genomics — disease identification (Orphanet), causative gene discovery, gene-disease validity (GenCC), variant interpretation (ClinVar), and translational research (ClinicalTrials.gov, drug repurposing for orphans). Use for rare-disease-gene curation, novel-gene-discovery analysis, and rare-disease drug-development support.

mims-harvard Bundle

Analyze CRISPR-Cas9 genetic screens — MAGeCK gene-level scores, sgRNA count QC, replicate correlation, hit prioritization, and pathway GSEA on screen output. Use for genome-wide essentiality screens, synthetic-lethality discovery, dropout vs positive-selection screen analysis, target identification, and resistance-screen interpretation. Includes screen-QC and statistical thresholds.

mims-harvard Bundle

Multi-omics integration — orchestrate per-layer analysis (transcriptomics, proteomics, epigenomics, genomics, metabolomics) then perform cross-omics correlation, multi-omics clustering, and pathway-level integration. Use for integrative systems-biology analysis, multi-modal disease characterization, and cross-omics biomarker discovery.

mims-harvard Skill

Small molecule identification, characterization, and procurement — PubChem, ChEMBL, BindingDB, ADMET-AI, SwissADME, eMolecules, Enamine. Covers compound name to structure to activity to ADMET properties to commercial sourcing. Use for chemical biology, lead identification, probe selection, and the full small-molecule discovery pipeline.

mims-harvard Skill

GPCR receptor pharmacology — agonist/antagonist/inverse-agonist/biased-agonist classification, GPCRdb structural data, receptor-ligand binding analysis, antibody-target interface (SAbDab). Use for GPCR drug discovery, biased-agonism analysis, receptor subtype selectivity questions, and orthosteric vs allosteric pocket characterization.

mims-harvard Bundle

Dereplicate a putative natural product and assign its chemical taxonomy. Use to answer "is [compound] a known natural product", "what microbe/organism produces [compound]", "what chemical class is [compound]", "dereplicate this metabolite (by formula/exact mass/InChIKey/SMILES)", or "classify this molecule into ChemOnt". Searches NPAtlas for known microbial natural products (producing organism + literature reference), assigns the ChemOnt kingdom→superclass→class→subclass hierarchy via ClassyFire, resolves systematic IUPAC names to structure via OPSIN, and cross-references identity in PubChem. NOT for general drug/compound identity or ADMET (use tooluniverse-chemical-compound-retrieval / tooluniverse-small-molecule-discovery) and NOT for metabolomics pathway/enrichment analysis (use tooluniverse-metabolomics skills).

mims-harvard Bundle

Genome-ASSEMBLY discovery, QC, and replicon mapping for any organism (bacteria, archaea, fungi, and beyond) using NCBI Datasets. Resolves an organism name or taxid to assemblies, picks the reference/representative or best-quality assembly, pulls assembly QC metrics (total length, contig/scaffold N50, contig count, GC%, assembly level, RefSeq category), enumerates chromosomes and plasmids via per-replicon sequence reports, and compares candidate assemblies on quality. Use for "what genomes are available for [organism]", "assembly stats / N50 / GC content for [GCF_/GCA_ accession]", "how many plasmids does [strain] have", "compare assemblies for [species]", "find the reference genome for [taxon]", "is this assembly Complete Genome or just contigs". NOT for gene-level orthology/synteny (use tooluniverse-comparative-genomics), plant gene structure (use tooluniverse-plant-genomics), de novo assembly from raw reads (no tool exists), or taxonomy-only name/lineage lookups.

terminalskills Bundle

Use fff (Fast File Finder) — a blazing-fast file search tool built in Rust with Node.js bindings, optimized for AI agents and Neovim integration. Supports fuzzy matching, regex, gitignore-aware filtering, and sub-millisecond search across large codebases. Use when tasks involve fast file discovery, AI agent tooling, or Neovim file navigation.

terminalskills Bundle

Meta-skill for discovering and invoking the right agent skill for any task. Use when starting a session, when unsure which skill applies, or when you need to understand the development lifecycle and how skills chain together. Covers skill discovery, core operating behaviors, and failure modes to avoid.

membranedev Skill

Backlog integration. Manage Projects. Use when the user wants to interact with Backlog data.

benedictking-exa-search Bundle

Semantic search skill using Exa API for embeddings-based search, similar content discovery, and structured research. Use when you need semantic search, find similar pages, or category-specific searches. Triggers: exa, semantic search, find similar, research paper, github search, 语义搜索, 相似内容

dstn2000 Bundle

Comprehensive Unreal Engine C++ and Blueprint development assistant with deep project structure understanding. Use when helping with Unreal Engine projects, including: C++ gameplay programming, Blueprint development, input system configuration (Enhanced Input), Gameplay Ability System (GAS), project structure navigation, asset discovery and referencing, plugin integration (experimental/beta), API lookups for underdocumented features, and debugging. Triggers on any Unreal Engine development question, especially when working within a .uproject directory.

fhidalgodev Bundle

Universal Odoo development skill based on strict OCA standards, covering versions 14-19. Includes agents for code review, upgrade analysis, and pattern discovery.