Results for “sui”

Knowledge-graph-augmented retrieval. Entity and triple extraction, graph construction (Neo4j, LlamaIndex PropertyGraphIndex), hierarchical community summarization (Microsoft GraphRAG), personalized PageRank (HippoRAG), multi-hop traversal retrieval, and hybrid graph + vector pipelines. USE WHEN: user mentions "GraphRAG", "HippoRAG", "knowledge graph RAG", "entity extraction", "multi-hop reasoning", "Neo4j RAG", "LlamaIndex property graph", "LangChain graph retriever", "triple extraction", "community summarization" DO NOT USE FOR: vanilla vector RAG - use `rag-patterns`; multimodal inputs - use `multimodal-rag`; production indexing ops - use `rag-production`; hallucination checks - use `rag-guardrails`

User-Mode Driver Framework v2 (UMDF). User-mode driver model that uses the same WDF object model as KMDF but runs in a host process (WUDFHost.exe) protected by the reflector. Required for some categories (Indirect Display Drivers, many sensor and camera drivers) and recommended for any driver that doesn't strictly need kernel mode. USE WHEN: user mentions "UMDF", "WUDFHost", "user-mode driver", "reflector", "IDD", "ISensor", "WDFHOST", "UMDF v2", "FX2" DO NOT USE FOR: KMDF (use `wdf-kmdf`), classic UMDF v1 (deprecated, COM-based)

Extract and preprocess tiles from whole-slide images (WSI) with histolab — OpenSlide-backed slide loading, tissue detection and masks, Random/Grid/Score tile extraction, and image/morphological filters for H&E preprocessing. Use when the user needs lightweight WSI slide preprocessing — building tile datasets for ML training, tissue segmentation, or quick tile-based inspection of histopathology slides. For end-to-end computational-pathology, deep-learning model training, nucleus segmentation, or multiplexed/spatial-proteomics (CODEX, Vectra) pipelines prefer alterlab-pathml instead. Part of the AlterLab Academic Skills suite.

Featurizes molecules for machine learning with molfeat (100+ featurizers) — ECFP/MACCS/MAP4 fingerprints, RDKit and Mordred physicochemical descriptors, and pretrained embeddings (ChemBERTa, ChemGPT, GIN) exposed as scikit-learn transformers that convert SMILES into feature vectors. Use when turning molecules into ML-ready feature matrices for QSAR/QSPR or virtual screening, or benchmarking fingerprint against descriptor and embedding representations; for training models and MoleculeNet benchmarks on those features prefer alterlab-deepchem, and for low-level fingerprint or descriptor primitives prefer alterlab-rdkit. Part of the AlterLab Academic Skills suite.

Create cross-platform agent skills from workflow descriptions. Activates when users ask to create an agent, automate a repetitive workflow, create a custom skill, or need advanced agent creation. Triggers on phrases like create agent for, automate workflow, create skill for, every day I have to, daily I need to, turn process into agent, need to automate, create a cross-platform skill, validate this skill, export this skill, migrate this skill. Supports single skills, multi-agent suites, transcript processing, template-based creation, interactive configuration, cross-platform export, and spec validation.

Run full computational-pathology workflows with PathML — whole-slide-image (WSI) analysis across 160+ slide formats, multiplexed immunofluorescence (CODEX, Vectra, MERFISH), nucleus segmentation/classification (HoVer-Net, HACTNet), tissue- and cell-graph construction, HDF5 dataset management, and deep-learning model training on pathology data. Use when the user builds end-to-end deep-learning pathology pipelines, analyzes multiplexed or spatial-proteomics slides, or segments nuclei. For lightweight H&E slide preprocessing, tissue masking, or plain Random/Grid/Score tile extraction prefer alterlab-histolab instead. Part of the AlterLab Academic Skills suite.

Predict biomolecular complexes with Chai-1, an open AlphaFold3-style model that folds multi-entity assemblies (proteins, ligands, nucleic acids) from a single typed FASTA — strong on antibody–antigen and protein–ligand complexes, with optional MSA and restraint inputs. Use when predicting an antibody–antigen complex, folding a mixed protein/ligand/nucleic-acid assembly described in one FASTA, or generating a complex with experimental restraints. For binding-affinity prediction or a ligand-focused co-fold prefer alterlab-boltz; for protein-only or protein–protein folding prefer alterlab-alphafold; to dock into a fixed receptor prefer alterlab-diffdock. Part of the AlterLab Academic Skills suite.

Co-fold biomolecular complexes with Boltz-2, an open AlphaFold3-style model — predict protein + ligand (SMILES/CCD), protein + nucleic-acid, and multi-chain structures in one pass, with binding-affinity prediction. Use when folding a protein together with a small-molecule ligand, predicting a holo (ligand-bound) complex or its binding affinity, or co-folding protein–DNA/RNA assemblies. For protein-only or protein–protein folding without ligands prefer alterlab-alphafold; for antibody–antigen complexes prefer alterlab-chai; to dock a ligand into a FIXED receptor structure prefer alterlab-diffdock; to look up an existing structure prefer alterlab-pdb. Part of the AlterLab Academic Skills suite.

Predict genome-wide functional genomics tracks from DNA sequence with Borzoi (Linder 2025) — a sequence-to-function model outputting RNA-seq, CAGE, ATAC, and ChIP coverage across long context, used to score non-coding and regulatory variant effects. Use when predicting functional tracks from a DNA sequence, scoring a non-coding/regulatory variant's effect on expression or chromatin, or doing in-silico mutagenesis of a locus. To LOOK UP a variant's population frequency prefer alterlab-gnomad; for its clinical significance prefer alterlab-clinvar; for protein-structure effects prefer alterlab-alphafold; for single-cell foundation models prefer alterlab-scgpt. Part of the AlterLab Academic Skills suite.

Simulator.Company digital-twin & actor-agent specialist — talk to an agent AS an agent and delegate work to it. An agent is ANY actor whose `description` holds an "# Agent" competency profile (what it does, what it knows, whether it fits a task). The common case is a person: every workspace user has a 1:1 twin actor (`systemObjType="user"`) carrying that profile. But any actor can be an agent — a service/bot twin, a team or department, an organization, a process. This skill discovers the agent (`findAgent`), loads its profile (`getAgent`), adopts it as the persona, then either does the task, finds a better-suited agent, or hands the decision to the user (for a person: a task or a p2p message; for a non-person: propose another executor or run/trigger it as an actor). It is the actor-analog of `simulator-skills` (the `Skills`-form registry), but the registry is the workspace's agent actors. Use when the user wants to "delegate", "assign this to <someone/something>", "can <X> do this", "who/what should do this",