Results for “pharmgkb”

24 skills

Alterlab Clinpgx

Access ClinPGx pharmacogenomics data (the successor to PharmGKB) to query gene-drug interactions, CPIC/DPWG dosing guidelines, drug labels, and pharmacogene records. Use when interpreting pharmacogenes (CYP2D6, CYP2C19, TPMT, DPYD, SLCO1B1), looking up genotype-guided drug dosing, checking PGx drug-safety associations (e.g. HLA-B*57:01 and abacavir), or supporting precision medicine and clinical pharmacogenomics decisions. For star-allele definitions/frequencies see PharmVar; for germline/somatic variant pathogenicity see alterlab-clinvar. Part of the AlterLab Academic Skills suite.

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Alphagbm Investment Thesis

Record buy rationale and structured sell conditions for stock positions, with automatic monitoring to detect when exit triggers fire.

mariadb-corporation

Documents MariaDB-specific GRANT behavior, including privilege scope levels, implicit account creation, MariaDB-only privileges, roles, proxy grants, resource limits, and TLS options, to help write accurate GRANT statements.

Mirago Prescribing Guide

Complete bedside prescribing reference for Mirago (mirabegron, beta-3 adrenoceptor agonist) for overactive bladder — covering contraindications, safety screening, drug interactions, dose selection in special populations, titration, and administration. Use when a clinician asks how to start mirabegron, what dose to use in renal or hepatic impairment, is mirabegron safe in this patient, mirabegron drug interactions, or Mirago for OAB.

Alphagbm Fear Score

Calculates a per-ticker panic index (0-100) from six weighted signals including VIX, IV Rank, RSI-14, volume anomaly, put/call ratio, and consecutive down days, triggering Bull Put Spread entry signals at scores ≥60.

Endo Pharmaco Eligibility

Assess pharmacotherapy eligibility based on BMI/comorbidity

Query the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biological data including genes, drugs, diseases, phenotypes, and more.

30.2k · bundle

Alphagbm Options Strategy

Recommends optimal multi-leg option strategies based on market view, with 15+ templates and full P&L profiles.

Alterlab Matchms

Computes mass-spectral similarity and identifies compounds for metabolomics with matchms — comparing mass spectra, scoring similarity (cosine, modified cosine), and searching spectral libraries to annotate unknowns. Use when matching MS/MS spectra, identifying metabolites, or library searching; for full LC-MS/MS proteomics pipelines use pyopenms. Part of the AlterLab Academic Skills suite.

Use when running HMMER master or worker daemon services that front `phmmer`, `hmmsearch`, and `hmmscan` against cached databases.

Alphagbm Pnl Simulator

Simulates profit and loss for option positions across underlying price, implied volatility, and time to expiration, generating diagrams, breakeven analysis, and probability distributions.

Gdb reference tool. Use when working with gdb in devtools contexts.

Set price, IV rank, unusual activity, earnings, and VRP alerts with contextual notifications and management commands.

Comprehensive guide to bohb. Master the concepts, implementation, best practices, and real-world applications of bohb in professional environments.

Exploiting Bgp Hijacking Vulnerabilities

Simulates BGP hijacking attacks in isolated lab environments to test RPKI deployment, route origin validation, and BGP monitoring defenses against prefix hijacking and route leak attacks.

24.6k · bundle

mariadb-corporation

Mariadb Connector J Usage

Explains MariaDB Connector/J JDBC driver behavior: auto-registration, URL schemes, prepared statement handling, batch inserts, transactions, fetch sizes, pooling, and failover. Use when writing or reviewing Java code that talks to MariaDB with the mariadb-java-client driver.

mariadb-corporation

Covers MariaDB-specific behavior of the mariadb command-line client, including batch mode output, delimiter handling, safe-updates, charset detection, and TLS defaults, for writing or reviewing shell commands and scripts.

Alterlab Chembl

Query ChEMBL via the chembl_webresource_client Python client for curated bioactive molecules and drug-like compound libraries at scale — search compounds by structure or physicochemical properties, retrieve bioactivity measurements (IC50, Ki, EC50), and find inhibitors of a target. Use when screening chemical libraries, mining curated bioactivity for a protein, running SAR studies, or sourcing medicinal-chemistry data; for measured protein-ligand binding affinities (Ki/Kd/IC50) prefer alterlab-bindingdb instead. Part of the AlterLab Academic Skills suite.

Comprehensive guide to bark. Master the concepts, implementation, best practices, and real-world applications of bark in professional environments.

Cnb Plugin Market

搜索 CNB 插件市场并生成流水线配置。

Filtros de química medicinal. Aplique regras de similaridade a fármacos (Lipinski, Veber), filtros PAINS, alertas estruturais, métricas de complexidade, para priorização de compostos e filtragem de bibliotecas.

T2dm Comorbidity Medicine Selector

Guides comorbidity-stratified selection of initial and further glucose-lowering medicines for adults with type 2 diabetes using the NICE NG28 (2026) framework, covering six clinical profiles: no relevant comorbidity, heart failure, atherosclerotic cardiovascular disease, early onset, obesity, chronic kidney disease, and frailty.

Alterlab Primekg

Queries the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biomedical relationships across genes, drugs, diseases, phenotypes, pathways, and biological processes. Use when exploring drug-disease or gene-disease links, building disease-centric knowledge subgraphs, or sourcing relations for drug repurposing and precision-medicine analyses. Part of the AlterLab Academic Skills suite.

mariadb-corporation

Explains MariaDB-specific REVOKE syntax and behavior, including the five grammar forms, privilege requirements, error semantics, and role/proxy revocation nuances.