Results for “polygenic-risk-score”

Calculates a per-ticker panic index (0-100) from six weighted signals including VIX, IV Rank, RSI-14, volume anomaly, put/call ratio, and consecutive down days, triggering Bull Put Spread entry signals at scores ≥60.

Compares prediction market probabilities from Polymarket with options-implied probabilities to identify mispricing signals and potential arbitrage opportunities.

Diagnose monogenic and syndromic obesity in children and adolescents using a structured step-by-step algorithm. Use this skill whenever a clinician suspects a genetic cause of obesity, asks about leptin deficiency, MC4R mutation, POMC deficiency, PCSK1 deficiency, leptin receptor deficiency, Bardet-Biedl syndrome, Prader-Willi syndrome, Alström syndrome, or any case of early-onset severe obesity with hyperphagia. Also trigger for questions about targeted pharmacotherapy including setmelanotide or metreleptin, or when to order a genomic obesity panel. Cross-references the NHS Genomic Test Finder skill to surface the relevant R-code once a diagnosis is reached.

Calculates CRAP (Change Risk Anti-Patterns) scores for .NET methods by combining cyclomatic complexity with code coverage data from Cobertura XML reports.

Create, apply, and manage AgentRC policies to customize readiness scoring, disable checks, override impact levels, set pass-rate thresholds, and enforce CI gating.

Diagnosing and fixing bimodal matching score distributions in MaxFuse

Use when implementing unified position sizing, Kelly criterion, or combining GARCH+Capital+Portfolio risk systems

Econometrics skill for instrumental variables and treatment effect estimation. Activates when the user asks about: "instrumental variables", "IV estimation", "2SLS", "two-stage least squares", "endogeneity", "weak instruments", "first stage", "Sargan test", "overidentification", "propensity score matching", "PSM", "average treatment effect", "ATT", "LATE", "local average treatment effect", "endogenous regressor", "instrument validity", "工具变量", "两阶段最小二乘", "内生性", "弱工具变量", "倾向得分匹配", "平均处理效应", "处理效应", "局部平均处理效应"

Calculate portfolio risk metrics including VaR, CVaR, Sharpe, Sortino, and drawdown analysis. Use when measuring portfolio risk, implementing risk limits, or building risk monitoring systems.

Runs a side-by-side walk-forward backtest of a Bull Put Spread strategy with and without a FearScore entry signal, comparing performance metrics over ~8 years of daily data.

Broad risk assessment — key-person, technical, regulatory, competitive, financial, and execution risks beyond product/market

Maps the current VIX value to a 5-tier fear-thermometer classification with strategy hints for options sellers, including 1-year percentile and distribution data.

Given a stock ticker, cost basis, and position purpose, classifies the holding scenario and returns concrete hedge recommendations (Long Put, Collar, Tier-down) with live option strikes and premiums.

Provides a single 0-100 cycle score blending VIX, SPY IV Rank, Put/Call ratio, and valuation percentile to determine offense vs. defense posture, based on Howard Marks' market cycle framework.

Recommends optimal multi-leg option strategies based on market view, with 15+ templates and full P&L profiles.

Guides choice among spironolactone, eplerenone, and esaxerenone for primary aldosteronism based on comparative efficacy, safety, and patient-specific factors. Triggers include when initiating MRA therapy and asking 'Which MRA should I prescribe?' or considering switching agents due to adverse effects, cost, or need for potassium supplementation.

Analyzes Stockbee-style Day 1 Episodic Pivot candidates by scoring catalyst quality alongside price/volume confirmation, gap/range expansion, volume shock, neglect/revaluation context, liquidity, and risk to the EP-day low.

Analyzes the volatility smile and skew for a single options expiration, providing implied volatility curves, skew metrics, and shape classification to reveal market pricing of tail risk and directional fear.

Computes the R2Score metric using torchmetrics, handling single and multi-output predictions with options for adjusted and variance-weighted scores.

PHOENIX v2.0 — Contribution Velocity Scanner (Hardened). Same battle-tested signal. Fixed trade counter. DSL plugin exits.

Implements comprehensive backtesting capabilities for Pine Script indicators and strategies. Use when adding performance metrics, trade analysis, equity curves, win rates, drawdown tracking, or statistical validation. Triggers on "backtest", "performance", "metrics", "win rate", "drawdown", or testing requests.

Use when tuning RL reward function weights, fixing reward hacking, or addressing P&L gradient issues

Score Analyzer

Use when implementing risk-adjusted rewards, discussing Sharpe ratio in RL training, or tuning reward components for risk awareness

在启动高风险项目或重要决策前，需要预先识别潜在失败点以增强心理韧性和方案鲁棒性时

Determines if PAC/PRA ratio and PAC levels indicate positive or provisionally positive screening for primary aldosteronism. Triggered when a clinician has PAC and PRA results and asks “Is this screening test positive for PA?” or needs to interpret borderline results.

Legal-specific Argument Ranking Engine. Hodnotí právní argumenty 17-sloupcovým scoringem (síla, bezpečnost, dopad, riziko + 10 legal-specific kritérií: Compliance s novelou 2026, Evidence backing, Time-sensitivity, per-document mapping, R-static/R-reversal split, Tom-weight bonus, C-XX/M-XX/N-XX/D-XX integrace). Output: priorizovaný seznam argumentů s kategoriemi CORE/SUPPORT/CONTEXT/EXCLUDED/SUMMARY a per-document bundles (PR/§909/40_06/195). Použití: pre-prioritizace argumentů před F11.x review, Phase 2 Verify input, DÁVKA 3, výživné L04, AT podání. VŽDY použij tento skill, když Tom (nebo legal/strat) zmíní: /lare, lare, argument ranking, ARE matrix, score arguments, prioritize arguments, argument bundle, CORE/SUPPORT/CONTEXT/EXCLUDED, ARE_F11, LARE_F11, legal argument evaluation, argument scoring, compliance scoring, Tom-weight.