Results for “protein”

12 skills

alterlab-string-db

Query the STRING API for protein-protein interactions (59M proteins, 20B interactions across 5000+ species), building interaction networks, discovering functional partners, and running GO/KEGG/Pfam enrichment on protein lists. Use when constructing a protein-protein interaction network, expanding from seed proteins to functional partners, or running PPI-based enrichment for systems biology; for curated metabolic pathway maps and reactions prefer alterlab-kegg, and for protein sequences, annotations, or accession ID mapping prefer alterlab-uniprot instead. Part of the AlterLab Academic Skills suite.

Conjunto abrangente de ferramentas para modelos de linguagem de proteínas, incluindo ESM3 (design multimodal generativo de proteínas em sequência, estrutura e função) e ESM C (embeddings e representações eficientes de proteínas). Use essa skill ao trabalhar com sequências de proteínas, estruturas ou predição de função; designing de proteínas inovadoras; geração de embeddings de proteínas; inverse folding; ou tarefas de engenharia de proteínas. Suporta tanto uso local de modelos quanto Forge API baseada em nuvem para inferência escalável.

Plataforma de laboratório em nuvem para testes e validação automatizados de proteínas. Use ao projetar proteínas e precisar de validação experimental incluindo ensaios de ligação, testes de expressão, medições de estabilidade térmica, ensaios de atividade enzimática ou otimização de sequências de proteínas. Use também para submeter experimentos via API, rastrear status de experimentos, baixar resultados, otimizar sequências de proteínas para melhor expressão usando ferramentas computacionais (NetSolP, SoluProt, SolubleMPNN, ESM), ou gerenciar workflows de design de proteínas com validação em laboratório úmido.

alterlab-uniprot

Provide direct REST API access to UniProt (Swiss-Prot/TrEMBL) for protein sequence searches, FASTA retrieval, functional annotations (GO terms, domains), and cross-database ID mapping. Use when looking up a protein entry, fetching a protein FASTA sequence, or mapping accessions between databases over raw HTTP/REST; for EXPERIMENTAL 3D structures prefer alterlab-pdb, for AI-PREDICTED 3D structures prefer alterlab-alphafold-db, for protein-protein interaction networks prefer alterlab-string-db, and for Python workflows spanning many databases prefer bioservices instead. Part of the AlterLab Academic Skills suite.

alterlab-interpro

Query the EMBL-EBI InterPro REST API for protein family, domain, and functional-site annotations integrated from member databases (Pfam, PANTHER, PRINTS, SMART, SUPERFAMILY, CDD, ProSite, NCBIfam, and others). Use when predicting protein function, analyzing or comparing domain architecture, classifying a protein by family or homologous superfamily, resolving a Pfam/InterPro accession, or mapping a protein's signatures to GO terms. Not for raw UniProt entry/FASTA retrieval or AlphaFold 3D structures. Part of the AlterLab Academic Skills suite.

More results

Submit protein sequences to the Adaptyv Bio Foundry for experimental characterization (binding, thermostability, expression, fluorescence) and retrieve results using the REST API or Python SDK.

Submit protein sequences to the Adaptyv Bio Foundry for experimental characterization (binding, thermostability, expression, fluorescence) and retrieve results via API or Python SDK.

30.2k · bundle

Primary Python tool for 40+ bioinformatics services. Preferred for multi-database workflows: UniProt, KEGG, ChEMBL, PubChem, Reactome, QuickGO. Unified API for queries, ID mapping, pathway analysis. For direct REST control, use individual database skills (uniprot-database, kegg-database).

cross-modal-normalization

Scale alignment for RNA-protein cross-modal integration - BOTH modalities must be z-scored

Provide direct REST API access to KEGG (academic use only) for pathway analysis, gene-to-pathway and compound-to-pathway mapping, metabolic reactions, KEGG Orthology (KO), drug-drug interactions, and ID conversion. Use when querying KEGG pathways, mapping genes/compounds to metabolic maps, or running KEGG pathway enrichment via raw HTTP/REST; for protein-protein interaction networks prefer alterlab-string-db, for protein sequences and annotations prefer alterlab-uniprot, and for Python workflows spanning many databases prefer bioservices instead. Part of the AlterLab Academic Skills suite.

alterlab-bindingdb

Query BindingDB for measured protein-ligand binding affinities (Ki, Kd, IC50, EC50) via its keyless REST API or the full TSV download, searching by target (UniProt ID), compound (SMILES), or pathogen. Use when looking up experimental binding constants, profiling inhibitors of a protein target, doing lead optimization, polypharmacology analysis, or structure-activity relationship (SAR) studies; for curated bioactivity mining or drug-like compound library screening at scale prefer alterlab-chembl instead. Part of the AlterLab Academic Skills suite.

Runs NCBI BLAST+ 2.17.0 sequence searches from the command line: makeblastdb (with -parse_seqids), blastn/blastp/blastx/tblastn with tabular -outfmt 6/7 for parsing, correct -task choice (megablast vs blastn vs blastn-short), -taxids/-negative_taxids taxonomic scoping, and -mt_mode multithreading; plus a DIAMOND blastp --ultra-sensitive path for large protein searches. Warns that -max_target_seqs is a heuristic keep-count, not a top-N best-hits filter. Use when the user wants command-line BLAST, makeblastdb, a local BLAST database, blastn/blastp/blastx/tblastn searches, or DIAMOND protein search. For the Bio.Blast web NCBIWWW API prefer alterlab-biopython; for quick one-liner database lookups prefer alterlab-gget. Part of the AlterLab Academic Skills suite.