Results for “pharmgkb”

Queries the ClinPGx REST API for pharmacogenomic gene-drug data, clinical annotations, CPIC guidelines, and FDA drug labels, generating markdown reports with CSV tables.

Audits a research knowledge base for stale profiles, thesis drift, and orphan pages, returning a 0-100 health score with actionable recommendations.

Build and manage company research profiles in a personal knowledge base, tracking fundamentals, valuation bands, red flags, and events with auto-refresh.

Searches UK Biobank's 12,000+ data fields and publications by natural language query, returning ranked field IDs and descriptions for research questions.

Access ClinPGx pharmacogenomics data (the successor to PharmGKB) to query gene-drug interactions, CPIC/DPWG dosing guidelines, drug labels, and pharmacogene records. Use when interpreting pharmacogenes (CYP2D6, CYP2C19, TPMT, DPYD, SLCO1B1), looking up genotype-guided drug dosing, checking PGx drug-safety associations (e.g. HLA-B*57:01 and abacavir), or supporting precision medicine and clinical pharmacogenomics decisions. For star-allele definitions/frequencies see PharmVar; for germline/somatic variant pathogenicity see alterlab-clinvar. Part of the AlterLab Academic Skills suite.

Record buy rationale and structured sell conditions for stock positions, with automatic monitoring to detect when exit triggers fire.

Documents MariaDB-specific GRANT behavior, including privilege scope levels, implicit account creation, MariaDB-only privileges, roles, proxy grants, resource limits, and TLS options, to help write accurate GRANT statements.

Esta habilidade deve ser usada ao trabalhar com LaminDB, um framework de dados de código aberto para biologia que torna dados consultáveis, rastreáveis, reproduzíveis e FAIR. Use ao gerenciar datasets biológicos (scRNA-seq, espacial, citometria de fluxo, etc.), rastrear workflows computacionais, curar e validar dados com ontologias biológicas, construir data lakehouses, ou garantir linhagem de dados e reprodutibilidade em pesquisa biológica. Aborda gerenciamento de dados, anotação, ontologias (genes, tipos de célula, doenças, tecidos), validação de esquema, integrações com orquestradores de workflow (Nextflow, Snakemake) e plataformas MLOps (W&B, MLflow), e estratégias de deployment.

Complete bedside prescribing reference for Mirago (mirabegron, beta-3 adrenoceptor agonist) for overactive bladder — covering contraindications, safety screening, drug interactions, dose selection in special populations, titration, and administration. Use when a clinician asks how to start mirabegron, what dose to use in renal or hepatic impairment, is mirabegron safe in this patient, mirabegron drug interactions, or Mirago for OAB.

Search scientific papers via the BGPT MCP server and retrieve structured experimental data — methods, results, conclusions, quality scores, and 25+ metadata fields per paper.

Prüft KG- und Personengesellschaften-Fälle in Großkanzlei Corporate/M&A-Mandaten: Frist, Form, Zuständigkeit, Rechtsweg und Sofortmaßnahmen; liefert eine Fristen- und Risikoampel mit Sofortschritten.

Query the Open Targets Platform GraphQL API for target-disease associations, tractability and safety data, genetics/omics evidence, and known drugs. Use when identifying or prioritizing therapeutic drug targets, assessing target druggability/safety, or gathering target-disease evidence for drug discovery. Part of the AlterLab Academic Skills suite.

Bulk-load text files into MariaDB tables using the mariadb-import client, covering table-name-from-filename rules, TAB defaults, --local vs server-side reads, duplicate handling, and parallel loads.

Diagnose and fix retention problems using the Fogg Behavior Model (B=MAP), covering motivation, ability, prompts, and tiny habits.

Calculates a per-ticker panic index (0-100) from six weighted signals including VIX, IV Rank, RSI-14, volume anomaly, put/call ratio, and consecutive down days, triggering Bull Put Spread entry signals at scores ≥60.

Maintains a PARA-structured knowledge base on disk for persistent project context, decisions, and architecture records across agent sessions.

Assess pharmacotherapy eligibility based on BMI/comorbidity

Query the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biological data including genes, drugs, diseases, phenotypes, and more.

Explains MariaDB Connector/Python's DB API 2.0 behavior, including qmark placeholders, autocommit, prepared statements, buffered cursors, connection pooling, and error handling, for writing and reviewing Python code that uses the mariadb module.

Recommends optimal multi-leg option strategies based on market view, with 15+ templates and full P&L profiles.

Query the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biological data including genes, drugs, diseases, phenotypes, and more.

Computes mass-spectral similarity and identifies compounds for metabolomics with matchms — comparing mass spectra, scoring similarity (cosine, modified cosine), and searching spectral libraries to annotate unknowns. Use when matching MS/MS spectra, identifying metabolites, or library searching; for full LC-MS/MS proteomics pipelines use pyopenms. Part of the AlterLab Academic Skills suite.

Runs NCBI BLAST+ 2.17.0 sequence searches from the command line: makeblastdb (with -parse_seqids), blastn/blastp/blastx/tblastn with tabular -outfmt 6/7 for parsing, correct -task choice (megablast vs blastn vs blastn-short), -taxids/-negative_taxids taxonomic scoping, and -mt_mode multithreading; plus a DIAMOND blastp --ultra-sensitive path for large protein searches. Warns that -max_target_seqs is a heuristic keep-count, not a top-N best-hits filter. Use when the user wants command-line BLAST, makeblastdb, a local BLAST database, blastn/blastp/blastx/tblastn searches, or DIAMOND protein search. For the Bio.Blast web NCBIWWW API prefer alterlab-biopython; for quick one-liner database lookups prefer alterlab-gget. Part of the AlterLab Academic Skills suite.

Use when running HMMER master or worker daemon services that front `phmmer`, `hmmsearch`, and `hmmscan` against cached databases.

MongoDB - NoSQL document database with flexible schema design, aggregation pipelines, indexing strategies, and Spring Data integration

Simulates profit and loss for option positions across underlying price, implied volatility, and time to expiration, generating diagrams, breakeven analysis, and probability distributions.

Gdb reference tool. Use when working with gdb in devtools contexts.

Set price, IV rank, unusual activity, earnings, and VRP alerts with contextual notifications and management commands.

Make sure to use this skill whenever the user mentions anything related to job searching on Akademikernes Jobbank, jobbank.dk, or looking for academic or highly educated positions in Denmark — even if they don't mention jobbank.dk explicitly. Also invoke this skill for questions about Danish job listings, graduate trainee positions, Ph.d. jobs, or finding work in specific industries or regions in Denmark. Trigger phrases include: jobbank, akademikernes jobbank, jobs denmark, academic jobs denmark, find job denmark, highly educated jobs, graduate job denmark, trainee position denmark, ph.d. position denmark, postdoc denmark, studiejob, fuldtidsjob, deltidsjob, vikariat, freelance job, praktikplads, job søgning, jobsøgning, søg job, ledige stillinger, nye jobs, it jobs denmark, engineering jobs denmark, marketing jobs denmark, finance jobs denmark, healthcare jobs denmark, remote job denmark, fjernarbejde, job københavn, job aarhus, job odense, nyuddannede job, job til nyuddannede, international job denmark, jo

Prüft Frist, Form, Zuständigkeit, Rechtsweg und Sofortmaßnahmen im Betreuungsrecht und liefert eine Fristen- und Risikoampel mit Sofortschritten.

Ordnet Akteninhalte, Belege, Lücken und Nachforderungen für B2B-Shops und Unternehmernachweise im E-Commerce-Recht; liefert ein direkt nutzbares Arbeitsprodukt mit Prüfpunkten, Risiken und nächstem Schritt.

Fintech Algérie — Banque d'Algérie, CIB, Edahabia, BaridiMob, réglementation bancaire DZ

Graph-based drug discovery toolkit. Molecular property prediction (ADMET), protein modeling, knowledge graph reasoning, molecular generation, retrosynthesis, GNNs (GIN, GAT, SchNet), 40+ datasets, for PyTorch-based ML on molecules, proteins, and biomedical graphs.

Comprehensive guide to bohb. Master the concepts, implementation, best practices, and real-world applications of bohb in professional environments.

Simulates BGP hijacking attacks in isolated lab environments to test RPKI deployment, route origin validation, and BGP monitoring defenses against prefix hijacking and route leak attacks.