Target Intelligence Tools
Use this skill when the user wants an integrated target brief rather than isolated API hits.
Typical triggers:
- build a quick dossier for a therapeutic target
- summarize what is known about a gene or protein target
- collect disease evidence, known drugs, pathways, and interaction partners in one report
- prepare a target-validation snapshot before docking, screening, or literature deepening
Environment Check
which python3 || true
python3 - <<'PY'
mods = ["requests"]
for name in mods:
try:
__import__(name)
print(f"{name}: ok")
except Exception as exc:
print(f"{name}: missing ({exc})")
PY
If outbound network access is blocked, say so explicitly before claiming the dossier ran.
Bundled Asset
templates/target_dossier.py
Preferred Workflow
- Start from the clearest target identifier available.
- Resolve the target to stable IDs first.
- Pull disease associations, known drugs, pathways, and interaction partners into one markdown dossier.
- Keep the output compact and explicit about missing data.
- Treat the dossier as a research briefing artifact, not a validated decision report.
Quick Start
python3 templates/target_dossier.py \
--query EGFR \
--output targets/egfr_dossier.md \
--summary targets/egfr_dossier.json \
--detail-json targets/egfr_dossier.detail.json
Output Expectations
Good answers should mention:
- the exact identifier or query used
- which stable IDs were resolved
- how many disease, drug, pathway, and interaction rows were found
- whether ClinVar or gnomAD constraint signals were available
- where the markdown dossier and summary JSON were written
Related Skills
For raw UniProt, PDB, ClinVar, gnomAD, Reactome, STRING, or OpenTargets queries, activate bio-db-tools.
For public compound and regulatory APIs such as ChEMBL, BindingDB, openFDA, ClinicalTrials.gov, or OpenAlex, activate pharma-db-tools.
For local variant-callset summarization before target interpretation, activate variant-analysis-tools.
1---2name: target-intelligence-tools3description: Target research workflow guide for building compact drug-target dossiers across protein identity, disease evidence, known drugs, interaction partners, pathways, and variant constraint signals. Use when the user asks for a target brief, target validation snapshot, or a one-file summary of what is known about a gene or protein target.4---56# Target Intelligence Tools78Use this skill when the user wants an integrated target brief rather than isolated API hits.910Typical triggers:11- build a quick dossier for a therapeutic target12- summarize what is known about a gene or protein target13- collect disease evidence, known drugs, pathways, and interaction partners in one report14- prepare a target-validation snapshot before docking, screening, or literature deepening1516## Environment Check1718```bash19which python3 || true20python3 - <<'PY'21mods = ["requests"]22for name in mods:23 try:24 __import__(name)25 print(f"{name}: ok")26 except Exception as exc:27 print(f"{name}: missing ({exc})")28PY29```3031If outbound network access is blocked, say so explicitly before claiming the dossier ran.3233## Bundled Asset3435- `templates/target_dossier.py`3637## Preferred Workflow38391. Start from the clearest target identifier available.402. Resolve the target to stable IDs first.413. Pull disease associations, known drugs, pathways, and interaction partners into one markdown dossier.424. Keep the output compact and explicit about missing data.435. Treat the dossier as a research briefing artifact, not a validated decision report.4445## Quick Start4647```bash48python3 templates/target_dossier.py \49 --query EGFR \50 --output targets/egfr_dossier.md \51 --summary targets/egfr_dossier.json \52 --detail-json targets/egfr_dossier.detail.json53```5455## Output Expectations5657Good answers should mention:58- the exact identifier or query used59- which stable IDs were resolved60- how many disease, drug, pathway, and interaction rows were found61- whether ClinVar or gnomAD constraint signals were available62- where the markdown dossier and summary JSON were written6364## Related Skills6566For raw UniProt, PDB, ClinVar, gnomAD, Reactome, STRING, or OpenTargets queries, activate `bio-db-tools`.67For public compound and regulatory APIs such as ChEMBL, BindingDB, openFDA, ClinicalTrials.gov, or OpenAlex, activate `pharma-db-tools`.68For local variant-callset summarization before target interpretation, activate `variant-analysis-tools`.
drugclaw