exon-research
- 20 skills
- 0 followers
- 11 hours ago last updated
- ▌ Genomi · exon-research bundleUse this skill for genetics, genome source, variant, gene, phenotype, disease, screen, pharmacogenomics, and Genomi install/setup maintenance questions.
- ▌ Prs · exon-researchApply published polygenic scores from PGS Catalog to approved local personal DNA and return raw weighted score plus overlap QC.
- ▌ Genomi Decode · exon-researchActivate this skill for "/genomi decode", "decode my genome", "decode my DNA", "show me the dashboard", "the Genomi dashboard", "one-shot rundown", or any all-at-once request that asks Genomi to compose every capability's findings into a single artifact. This is the whole-genome dashboard kicker — it sweeps every relevant Genomi capability in one shot, not a per-target lookup. Composes evidence from every relevant Genomi capability into a single self-contained Genomi Dashboard.html and returns localhost serve metadata. Active genome required.
- ▌ Genomi Gnomad · exon-researchFetch reusable public population allele frequencies from gnomAD for a specific variant. Use when the user asks about allele frequency, MAF, population stratification, gnomAD numbers, or rarity of a specific allele.
- ▌ Clinvar · exon-researchBuild and inspect ClinVar exact-match evidence and candidate inventories. Use for clinical labels, VUS/conflict, carrier context, and drug-response rows.
- ▌ Journal · exon-researchMaintain agent-authored investigation memory over Genomi evidence links, reviewed source findings, decisions, contradictions, and unresolved questions.
- ▌ Ancestry · exon-researchUse local ancestry reference-panel tools for 1000 Genomes GRCh37/GRCh38 PCA projection, marker overlap QC, and qualitative reference-neighbor context.
- ▌ Sequence · exon-researchDeterministic sequence utilities for translation, ORFs, restriction sites, Kozak context, primer checks, and local FASTA record matching.
- ▌ Genomilab · exon-research bundleRun or continue patient-authorized, genome-informed GenomiLab investigations in the current Claude, Codex, or other MCP agent task. Use when a patient asks to open the Research Desk, investigate a condition against their active genome, review an existing investigation, supply follow-up information, revise a hypothesis, or publish a revised investigation response.
- ▌ Drug Targets · exon-researchCausal drug-target and mechanism gene prioritization from public source records, drugs, drug classes, mechanisms, and candidate gene lists.
- ▌ Gwas Catalog · exon-researchCompare candidate rsIDs against GWAS Catalog phenotype associations. Use association evidence with source and ancestry limitations.
- ▌ Nutrigenomics · exon-researchCurated single-marker evidence for declared nutrient-metabolism, food-tolerance, and taste-perception domains. Refuses diet prescriptions, supplement dosing, weight-loss prediction, methylation-cycle prescriptions, microbiome-mediated effects, and other out-of-scope nutrigenomic claims.
- ▌ Genomic Inquiry · exon-researchDefault entry for natural-language DNA questions. The host agent resolves intent, reads focused skills, calls narrow evidence tools, and adapts after inspecting tool output.
- ▌ Journal Source Research · exon-researchJournal sub-skill for focused public/source evidence review and reviewed finding write-back before interpretation or answer synthesis.
- ▌ Pharmacogenomics · exon-researchAnswer drug-response, medication, PharmGKB-style, PGxDB, ATC, DrugBank, gene-drug, and variant-drug questions using public PGx evidence plus local sample genotype support when an Active Genome Index is selected.
- ▌ Variant Evidence · exon-researchAnswer specific rsID, allele, gene, region, genotype, and absence/callability questions using explicit session context or public evidence.
- ▌ Active Genome Index · exon-researchRegister, parse, and digitize private genome source files into a local Active Genome Index and supporting evidence stores. Use when the session explicitly supplies a VCF/gVCF, BAM, genome.computer .genome/1.0 bundle, 23andMe raw genotype export, AncestryDNA raw genotype export, MyHeritage raw genotype export, FamilyTreeDNA Family Finder export, Living DNA autosomal export, supported source zip/tar, or known Active Genome Index.
- ▌ Functional Genomics · exon-researchCandidate gene evidence from perturbation, dependency, resistance, sensitivity, viability, or assay-context records.
- ▌ Rare Disease Cancer · exon-researchPlan rare disease, hereditary disease, cancer risk, carrier-relevance, and observed-condition source investigation from public targets or selected active genome evidence.
- ▌ Analytical Grounding · exon-researchRetrieve canonical pathway members, cell-type marker records, and genomic interval feature overlaps from declared analytical sources.