Product & Planning

bg-szy Bundle

Produce first drafts that match a writer's authentic voice using their Voice DNA Document. Consumes DNA documents from writing-dna-discovery skill. Generates 2 meaningfully different drafts with headlines, confidence assessment, decision notes, and DNA refinement suggestions. Collaborative partner that evaluates, pushes back, and advocates for quality. Handles blog posts, essays, newsletters, and more.

bg-szy Skill

Designs and deploys custom agent teams for specific business workflows. Interactive discovery of business processes, then generates complete team configurations with specialized agent roles, tool access, communication protocols, and handoff rules.

bg-szy Skill

AI-powered analysis of long-read sequencing data (PacBio, ONT) for structural variant detection, isoform discovery, epigenetic modifications, and de novo assembly.

bg-szy Skill

AI-powered time-resolved cryo-EM analysis for capturing protein dynamics, drug-binding kinetics, and conformational transitions for dynamics-based drug discovery.

bg-szy Skill

Comprehensive AI-powered tumor microenvironment immune profiling integrating bulk deconvolution, single-cell analysis, and spatial transcriptomics for immunotherapy biomarker discovery.

bg-szy Skill

Capture a writer's voice DNA through collaborative interview and sample analysis. Use when someone wants to document their writing voice for use with a ghost writer skill. Produces a Voice DNA Document with patterns, anti-patterns, and actionable guidance. Handles one register/mode per session, supports refinement over time.

bg-szy Skill

AI-powered pan-cancer analysis integrating genomic, transcriptomic, proteomic, and epigenomic data for cancer subtyping, driver identification, and cross-cancer pattern discovery.

bg-szy Skill

AI-powered analysis of patient-derived organoid (PDO) drug screening for personalized oncology treatment selection and biomarker discovery.

bg-szy Skill

AI-powered molecular glue discovery for targeted protein degradation, enabling neo-substrate recruitment and undruggable target degradation through E3 ligase interface modulation.

bg-szy Skill

Therapeutics Data Commons (TDC) AI-ready drug discovery datasets. Curated ADME, toxicity, DTI, DDI with scaffold/cold splits, standardized metrics, molecular oracles, and ADMET benchmarks for therapeutic ML and property prediction. For chemical database queries use chembl-database-bioactivity; for featurization use molfeat.

bg-szy Bundle

End-to-end biomarker discovery workflow from expression data to validated biomarker panels. Covers feature selection with Boruta/LASSO, classifier training with nested CV, and SHAP interpretation. Use when building and validating diagnostic or prognostic biomarker signatures from omics data.

bg-szy Bundle

Align RNA-seq reads with STAR (Spliced Transcripts Alignment to a Reference). Supports two-pass mode for novel splice junction discovery. Use when aligning RNA-seq data requiring splice-aware alignment.

bg-szy Bundle

End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immunogenicity scoring. Use when identifying tumor neoantigens for personalized vaccine design or checkpoint biomarkers.

bg-szy Bundle

Discover novel miRNAs and quantify known miRNAs using miRDeep2 de novo prediction from small RNA-seq data. Use when identifying new miRNAs or performing comprehensive miRNA profiling with discovery.

bg-szy Skill

Surface ebook ideas you didn't know you had. Use when ready to discover what ebooks might be hiding in your content, expertise, or thinking. Supports both content-rich creators (blog posts, videos, newsletters) and those with unpublished expertise. Produces a curated list of ebook candidates ready for Concept Development. Handles multi-session discovery with living documents.

bg-szy Bundle

Use the AgentD workflow to mine evidence, design molecules, and rank candidates with SAR plus ADMET annotations for early drug discovery tasks.

nota-america Bundle

This skill should be used when the user asks to "create a plugin", "scaffold a plugin", "understand plugin structure", "organize plugin components", "set up plugin.json", "use ${CLAUDE_PLUGIN_ROOT}", "add commands/agents/skills/hooks", "configure auto-discovery", or needs guidance on plugin directory layout, manifest configuration, component organization, file naming conventions, or Claude Code plugin architecture best practices.

nota-america Skill

Write a feature spec or PRD from a problem statement or feature idea. Use when turning a vague idea or user request into a structured document, scoping a feature with goals and non-goals, defining success metrics and acceptance criteria, or breaking a big ask into a phased spec.

nota-america Skill

Update, create, or reprioritize your product roadmap. Use when adding a new initiative and deciding what moves to make room, shifting priorities after new information comes in, moving timelines due to a dependency slip, or building a Now/Next/Later view from scratch.

nota-america Skill

Plan a sprint — scope work, estimate capacity, set goals, and draft a sprint plan. Use when kicking off a new sprint, sizing a backlog against team availability (accounting for PTO and meetings), deciding what's P0 vs. stretch, or handling carryover from the last sprint.

bg-szy Bundle

Implements nested cross-validation and stratified splits for unbiased model evaluation on biomedical datasets. Prevents data leakage and overfitting in biomarker discovery. Use when validating classifiers or optimizing hyperparameters on omics data.

bg-szy Bundle

Preprocess small RNA sequencing data with adapter trimming and size selection optimized for miRNA, piRNA, and other small RNAs. Use when preparing small RNA-seq reads for downstream quantification or discovery analysis.

bg-szy Bundle

Perform in silico gene knockout analysis and synthetic lethality screens using COBRApy single and double deletions. Predict essential genes and identify synthetic lethal pairs for drug target discovery. Use when identifying essential genes or finding synthetic lethal drug targets.

bg-szy Bundle

Selects informative features for biomarker discovery using Boruta all-relevant selection, mRMR minimum redundancy, and LASSO regularization. Use when identifying biomarkers from high-dimensional omics data.

bg-szy Skill

Multi-omic biomarker discovery studio that ingests expression + metadata, performs QC, multi-strategy feature selection, nested CV model training, survival analysis hooks, and SHAP-based interpretation. Use to design translational biomarker panels with documented evidence.

bg-szy Skill

Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.

bg-szy Bundle

AI video generation for agents through Luxin's zero-setup hosted creative runtime. Use when a prompt should become a durable hosted video without provider credentials, OAuth, local runtime, or per-provider billing. Start with the no-spend guide, choose a video model, and keep model discovery, jobs, costs, URLs, JSON recovery, payments, and feedback in one loop.

tuyv Bundle

Generates a Product Requirements Document from a natural language app description. Asks clarifying questions, researches similar apps, defines scope, stack, architecture, and produces a structured PRD that Archon can decompose into a campaign.

tuyv Bundle

Semantic file discovery via `vexor`. Use whenever locating where something is implemented/loaded/defined in a medium or large repo, or when the file location is unclear. Prefer this over manual browsing.

tuyv Bundle

Search, install, and wire registry blocks and components into HyperFrames compositions. Use BEFORE hand-building any named visual — whenever a brief, a user, or a storyboard names a look, effect, treatment, or transition such as CRT scanlines, glitch, chromatic aberration, film grain, a shimmer sweep, a chart, a code or terminal window, a map, or a confetti burst — because roughly 400 hosted items already cover many of them and the search ranks all of them with nothing installed, no project, and no account. Also use when running hyperframes add or hyperframes catalog, installing one item or every block matching a tag, wiring an installed item into index.html, or working with hyperframes.json. Covers discovery, install locations, block sub-composition wiring, component snippet merging, and authoring a new block or component to contribute upstream (idea → scaffold → validate → PR).

tuyv Bundle

Identify and suppress globally unsubscribed contacts to ensure legal compliance and reduce billing. Hybrid approach: API for discovery and audit, manual UI for suppression (hs_marketable_status is read-only).

tuyv Bundle

Map every stakeholder before engaging anyone. Use when launching an initiative, scoping discovery, or building an engagement plan from scratch.

tuyv Bundle

Suede-affiliated Amazon money-recovery audit for restocking fees, short or denied refunds, and Amazon-billed subscriptions. Use when the user mentions a restocking fee, a short or denied Amazon refund, or a forgotten Prime Video Channel, Audible, Kindle Unlimited, or Prime charge, or asks whether Amazon still owes or bills them. Read-only discovery; no chat, cancellation, or dispute without the account owner's per-item confirmation, and never a promise of recovery. Requires an authenticated Claude in Chrome session. NOT FOR: bank chargebacks, marketplace A-to-z seller claims, price-protection claims, or subscriptions billed outside Amazon (use subscription-recovery).

tuyv Bundle

Plan engagement for a specific stakeholder. Use when preparing an outreach, navigating resistance, or aligning a critical relationship before a key milestone.

tuyv Bundle

Given a PRD, produces an implementation architecture: file tree, component breakdown, data model, and a phased build plan with end conditions that Archon can execute directly. Multi-candidate evaluation for key decisions.

tuyv Bundle

Multi-repo campaign coordinator. Same lifecycle as fleet -- scope claims, discovery relay, wave-based execution -- but the unit of work is a repo, not a file. Coordinates campaigns across repositories with shared context.