Results for “polygenic-risk-score”

Computes evidence-aware polygenic risk scores from local VCF or WGS files using the just-prs engine and a pinned local MCP server, with honest interpretation and model comparison.

Takes raw whole-genome sequencing FASTQ files or a pre-existing VCF through variant calling, quality control, and polygenic risk score computation using the PGS Catalog.

Calculates a per-ticker panic index (0-100) from six weighted signals including VIX, IV Rank, RSI-14, volume anomaly, put/call ratio, and consecutive down days, triggering Bull Put Spread entry signals at scores ≥60.

Score and rank options contracts for any ticker using a multi-factor model covering liquidity, IV attractiveness, Greeks balance, and risk/reward. Returns scored option chains with the best contracts highlighted.

Assigns behavioral trust grades (A–F) to MCP servers by running probes for prompt injection, permission overreach, data leaks, and adversarial-input handling, and publishes reproducible onchain attestations.

Provides a structured risk scoring methodology for Data Protection Impact Assessments aligned with ENISA threat taxonomy and ISO 29134. Covers likelihood and severity assessment, risk matrix construction, inherent vs residual risk calculation, and risk appetite thresholds per EDPB WP248rev.01 guidance. Keywords: risk scoring, DPIA risk matrix, likelihood, severity, ENISA, ISO 29134, residual risk, risk appetite.

Compares prediction market probabilities from Polymarket with options-implied probabilities to identify mispricing signals and potential arbitrage opportunities.

Diagnose monogenic and syndromic obesity in children and adolescents using a structured step-by-step algorithm. Use this skill whenever a clinician suspects a genetic cause of obesity, asks about leptin deficiency, MC4R mutation, POMC deficiency, PCSK1 deficiency, leptin receptor deficiency, Bardet-Biedl syndrome, Prader-Willi syndrome, Alström syndrome, or any case of early-onset severe obesity with hyperphagia. Also trigger for questions about targeted pharmacotherapy including setmelanotide or metreleptin, or when to order a genomic obesity panel. Cross-references the NHS Genomic Test Finder skill to surface the relevant R-code once a diagnosis is reached.

Calculates CRAP (Change Risk Anti-Patterns) scores for .NET methods by combining cyclomatic complexity with code coverage data from Cobertura XML reports.

Create, apply, and manage AgentRC policies to customize readiness scoring, disable checks, override impact levels, set pass-rate thresholds, and enforce CI gating.

Diagnosing and fixing bimodal matching score distributions in MaxFuse

Use when implementing unified position sizing, Kelly criterion, or combining GARCH+Capital+Portfolio risk systems

Econometrics skill for instrumental variables and treatment effect estimation. Activates when the user asks about: "instrumental variables", "IV estimation", "2SLS", "two-stage least squares", "endogeneity", "weak instruments", "first stage", "Sargan test", "overidentification", "propensity score matching", "PSM", "average treatment effect", "ATT", "LATE", "local average treatment effect", "endogenous regressor", "instrument validity", "工具变量", "两阶段最小二乘", "内生性", "弱工具变量", "倾向得分匹配", "平均处理效应", "处理效应", "局部平均处理效应"

Calculate portfolio risk metrics including VaR, CVaR, Sharpe, Sortino, and drawdown analysis. Use when measuring portfolio risk, implementing risk limits, or building risk monitoring systems.

Econometrics skill for instrumental variables and treatment effect estimation. Activates when the user asks about: "instrumental variables", "IV estimation", "2SLS", "two-stage least squares", "endogeneity", "weak instruments", "first stage", "Sargan test", "overidentification", "propensity score matching", "PSM", "average treatment effect", "ATT", "LATE", "local average treatment effect", "endogenous regressor", "instrument validity", "工具变量", "两阶段最小二乘", "内生性", "弱工具变量", "倾向得分匹配", "平均处理效应", "处理效应", "局部平均处理效应"

Queries prediction market data from Polymarket's public API and provides market analysis with risk management guidance.

Runs a side-by-side walk-forward backtest of a Bull Put Spread strategy with and without a FearScore entry signal, comparing performance metrics over ~8 years of daily data.

Broad risk assessment — key-person, technical, regulatory, competitive, financial, and execution risks beyond product/market

Maps the current VIX value to a 5-tier fear-thermometer classification with strategy hints for options sellers, including 1-year percentile and distribution data.

Integrate FIRST's Exploit Prediction Scoring System (EPSS) API to prioritize vulnerability remediation based on real-world exploitation probability within 30 days.

Detects whether current market conditions match David Tepper's historic panic-buy signal by combining VIX, FearScore, and a quality filter.

VS-Enhanced Literature Review Strategist - Comprehensive support for multiple review methodologies Full VS 5-Phase process: Prevents Mode Collapse and presents creative search strategies Supports: Systematic Review (PRISMA 2020), Scoping Review (JBI/PRISMA-ScR), Meta-Synthesis, Realist Synthesis, Narrative Review, Rapid Review Use when: conducting any type of literature review, systematic reviews, meta-analyses, scoping reviews, finding prior research Triggers: literature review, PRISMA, systematic review, scoping review, meta-synthesis, realist synthesis, narrative review, rapid review

Given a stock ticker, cost basis, and position purpose, classifies the holding scenario and returns concrete hedge recommendations (Long Put, Collar, Tier-down) with live option strikes and premiums.

Provides a single 0-100 cycle score blending VIX, SPY IV Rank, Put/Call ratio, and valuation percentile to determine offense vs. defense posture, based on Howard Marks' market cycle framework.

Recommends optimal multi-leg option strategies based on market view, with 15+ templates and full P&L profiles.

Evidence-based health research using tiered trusted sources with GRADE-inspired evidence ratings. Integrates Apple Health data for personalized context. Use when user asks health, nutrition, exercise, sleep, or wellness questions.

Guides choice among spironolactone, eplerenone, and esaxerenone for primary aldosteronism based on comparative efficacy, safety, and patient-specific factors. Triggers include when initiating MRA therapy and asking 'Which MRA should I prescribe?' or considering switching agents due to adverse effects, cost, or need for potassium supplementation.

Composite skill — full security pass across secrets, dependencies, code paths, and OWASP risks. Chains security-audit (broad) + socket-audit (npm supply chain) + semgrep (pattern scan) + code-security (code review for vulns) in parallel, reconciles into one severity-ranked report with remediation plan. Use quarterly per active repo or before any release of security-sensitive code.

Audit a Supabase/Postgres project for Row-Level Security and access-control gaps, then produce a phased remediation plan. Use when "RLS", "is my Supabase secure", "anyone can read my data", "lock down my tables". App-layer session/route gates → audit-auth-flows.

Analyzes Stockbee-style Day 1 Episodic Pivot candidates by scoring catalyst quality alongside price/volume confirmation, gap/range expansion, volume shock, neglect/revaluation context, liquidity, and risk to the EP-day low.

Analyzes the volatility smile and skew for a single options expiration, providing implied volatility curves, skew metrics, and shape classification to reveal market pricing of tail risk and directional fear.

Computes the R2Score metric using torchmetrics, handling single and multi-output predictions with options for adjusted and variance-weighted scores.

Scale alignment for RNA-protein cross-modal integration - BOTH modalities must be z-scored

PHOENIX v2.0 — Contribution Velocity Scanner (Hardened). Same battle-tested signal. Fixed trade counter. DSL plugin exits.