Latest Agent Skills

Expert NIST Cybersecurity Framework (CSF) advisor covering CSF 2.0 and CSF 1.1. Use this skill whenever a user asks about NIST CSF, cybersecurity risk management, the six CSF functions (Govern, Identify, Protect, Detect, Respond, Recover), CSF profiles, implementation tiers, gap assessments, organizational profiles, community profiles, CSF core subcategories, informative references, or mapping to other frameworks (NIST SP 800-53, ISO 27001, CIS Controls, COBIT). Also trigger for questions like "how do I implement NIST CSF?", "what does CSF 2.0 change?", "help me build a CSF profile", "how do I assess my cybersecurity posture?", or any request involving organizational cybersecurity risk strategy or framework alignment.

Expert GDPR compliance assistant covering all four core workflows: (1) auditing code and systems for GDPR violations, (2) drafting GDPR-compliant documents such as privacy policies, Data Processing Agreements (DPAs), and consent notices, (3) answering GDPR compliance questions with authoritative article citations, and (4) reviewing data flows and PII handling practices. Use this skill whenever the user mentions GDPR, data protection, privacy compliance, lawful basis, data subject rights, DPA, privacy notices, consent management, data breaches, DPIAs, controller/ processor relationships, cross-border data transfers, or any EU/UK data privacy topic. Also trigger for questions like "is this GDPR compliant?", "how do I handle personal data?", "what does a privacy policy need?", or any request involving PII, personal data, or data retention in a regulatory context.

Expert ISO 42001 AI Management System (AIMS) compliance advisor. Use this skill whenever a user asks about ISO/IEC 42001:2023, AI governance, AI management systems, AI risk assessment, AI system impact assessment, Annex A controls for AI, Statement of Applicability for AI systems, AI policy, responsible AI, AI lifecycle management, AI incident management, AI transparency, AI bias, AI certification readiness, or any topic related to implementing or auditing an AI Management System. Also trigger for questions like "how do I become ISO 42001 certified?", "what controls does ISO 42001 require?", "how do I assess AI risk under 42001?", "what is an AIMS?", or any request involving organisational governance of AI systems, responsible AI frameworks, or AI regulatory compliance aligned to an ISO standard.

Expert guidance for FedRAMP certification and compliance. Use this skill whenever a user asks about FedRAMP authorization, ATO (Authority to Operate), cloud security for federal government, NIST SP 800-53 controls, CSP compliance, or any of the core FedRAMP document types: SSP, SAP, SAR, POA&M, CIS/CRM workbooks. Also trigger for questions about FedRAMP impact levels (Low, Moderate, High, LI-SaaS), FedRAMP 20x, OSCAL, 3PAO assessments, continuous monitoring (ConMon), gap assessments, system boundary definition, FedRAMP readiness, or architecture reviews for federal cloud. When in doubt, use this skill — it covers the full FedRAMP lifecycle from readiness through continuous monitoring.

Expert India Digital Personal Data Protection Act, 2023 (DPDPA) compliance advisor. Use this skill whenever a user asks about the DPDPA, DPDP Act, DPDP Rules 2025, India data privacy law, Data Fiduciary obligations, Data Principal rights, Significant Data Fiduciary, Data Protection Board of India, consent under DPDPA, notice requirements, breach notification India, children's data India, cross-border data transfer India, India privacy compliance, DPDPA gap analysis, DPDPA vs GDPR, or any obligation under India's personal data protection framework. Also trigger for: "Section 6 consent", "Section 7 legitimate uses", "Section 9 children's data", "Section 10 SDF", "Section 16 cross-border", "Rule 6 breach notification", "Rule 13 SDF obligations", "Data Protection Board complaint", "verifiable parental consent India", "DPDPA compliance roadmap", or "India privacy law global company".

Expert SOC 2 compliance assistant covering all five Trust Services Criteria (Security/CC, Availability/A, Confidentiality/C, Processing Integrity/PI, Privacy/P). Use this skill whenever a user mentions SOC 2, Trust Services Criteria, SOC 2 Type 1 or Type 2, audit readiness, compliance gaps, control documentation, evidence collection, vendor risk questionnaires, or anything related to AICPA service organization controls. Trigger even for adjacent topics like "we need to get audited", "a customer asked for our security report", "writing an information security policy", or "preparing for an audit". Covers gap analysis, policy writing, control documentation, audit evidence preparation, and vendor risk reviews for organizations at any maturity level — from first-time startups to seasoned compliance teams.

Expert DORA (Regulation (EU) 2022/2554 — Digital Operational Resilience Act) compliance advisor for EU financial entities. Use this skill whenever a user asks about DORA compliance, ICT risk management frameworks, ICT incident classification or reporting, threat-led penetration testing (TLPT), ICT third-party risk management, Register of Information, contractual provisions with ICT providers, ICT concentration risk, oversight of critical ICT third-party service providers (CTPPs), or any DORA RTS/ITS obligation. Also trigger for: "DORA gap analysis", "DORA readiness", "Art. 6 ICT risk framework", "Art. 17 incident reporting", "Art. 26 TLPT", "Art. 28 third-party policy", "Art. 30 contractual provisions", "Register of Information CIR 2024/2956", "critical TPSP designation", "DORA vs NIS2", "DORA simplified framework", or EBA/ESMA/EIOPA digital resilience guidance.

Use when collecting sorted UID lists from EDirect query sources such as PubMed queries, explicit IDs, WebEnv history state, or input files.

Use when working with NCBI ASN.1 module files, schema exports, or ASN.1/XML conversion tasks that require the `datatool` command.

Use when you need to remove adapter sequences from high-throughput sequencing reads, trim low-quality bases, or filter reads by length. Supports single-end and paired-end FASTQ/FASTA input with error-tolerant adapter matching.

Use when performing multiple sequence alignments on protein or nucleotide sequences, generating phylogenetic trees, or producing alignment output in various formats.

Use when resolving structured citation fields or citation XML into candidate PubMed IDs with EDirect matching modes.

Use when performing genome arithmetic on interval files (BED, BAM, BEDGRAPH), including intersection, merging, coverage, format conversion, or sequence extraction.

Use when working with VCF/BCF variant files for indexing, manipulation, analysis, or variant calling.

Use when searching a local NCBI EDirect archive/postings index with Boolean, title, word, or pair queries inside the `x*` local-cache workflow.

Use when extracting INSDSeq XML feature tables into tab-delimited text for downstream parsing or annotation review.

Use when converting NCBI XML sequence records to FASTA format, typically after fetching data with efetch from the Entrez Direct toolkit.

Use when filtering a UID stream against a local postings index with a query expression in the `x*` local-archive toolchain.

Use when searching nucleotide sequences against a nucleotide database using translated protein comparison. Useful for detecting distant evolutionary relationships between nucleotide sequences.

Use when searching protein query sequences against a translated nucleotide database to identify protein-coding regions or homologs in genomic data.

Use when converting tabular text into XML for downstream EDirect or XML-based processing.

Use when you need to annotate BAM alignments with a two-character tag based on overlaps with BED, GFF, or VCF annotation files, such as labeling reads by feature class or interval source.

Use when aligning long FASTQ reads to a reference genome with Subread's long-read aligner, optionally in RNA-seq mode.

Use when aligning RNA-seq reads to a reference genome with junction detection, including exon-exon junctions and gene fusions.

Use when converting NCBI dbSNP docsum XML into flat tabular rows through the bundled `snp2hgvs | hgvs2spdi | spdi2tbl` pipeline.

Use when converting SCN-format records into XML for downstream EDirect or XML-based processing.

Use when turning `bcftools roh` output plus a VCF/BCF into an interactive HTML visualization of ROH segments and homozygosity rates.

Use when visualizing RNA secondary structures from dot-bracket notation or Stockholm alignments, generating structure diagrams, or creating annotated consensus structure plots.

Use when screening a small query RNA against longer target RNA sequences for inter-molecular hybridization sites, especially when optional RNAplfold accessibility profiles should influence the ranking.

Use when performing pairwise structural alignments of RNA sequences that incorporate both sequence and structure information through base pair propensity vectors.

Use when computing RNA specific heat profiles from sequence data to analyze melting behavior and thermal stability across temperature ranges.

Use when predicting RNA secondary structures, calculating minimum free energy (MFE) folds, or computing partition functions and base pairing probabilities for RNA sequences.

Use when evaluating the free energy (kcal/mol) of an RNA secondary structure, calculating co-folding energies for two RNA strands, or analyzing consensus structures from multiple sequence alignments.

Use when converting `PubmedArticle` XML into `Pubmed-entry` ASN.1 text, or into the intermediate XML form used before final ASN.1 emission.

Use when converting `PubmedArticle` XML from EDirect into APA-style citation text or APA-structured XML for downstream parsing.

Use when profiling nucleotide content (AT/GC percentages, base counts) of genomic intervals against a FASTA reference.

Use when you need to aggregate quality control reports from multiple bioinformatics tools into a single HTML report

Use when you need to apply aggregation functions (sum, mean, count, etc.) to values from overlapping intervals in one file and map them onto intervals from another file.

Use when simulating stochastic folding kinetics of single-stranded nucleic acids, computing first passage times between structures, or analyzing RNA/DNA folding trajectories.

Use when inferring maximum-likelihood phylogenetic trees, selecting substitution models, running bootstrap support analyses, or performing partitioned phylogenetic analyses on sequence alignments.

Use when converting INI-style configuration files into XML for downstream EDirect or XML-based processing.

Use when you need to identify, view, or copy HTS-format files (BAM, CRAM, VCF, BCF). Use for inspecting file headers or viewing textual representations of binary HTS files.

Use when you need to inspect and summarize statistics for HMM (profile hidden Markov model) files from the HMMER suite.

Use when searching protein sequences against profile hidden Markov models (HMMs) such as Pfam or other HMM databases.

Use when running HMMER master or worker daemon services that front `phmmer`, `hmmsearch`, and `hmmscan` against cached databases.

Use when extracting per-position residue-height and indel-rate data from a profile HMM for sequence-logo visualization.

Use when sampling synthetic sequences, alignments, or consensus sequences from one or more profile HMMs.

Use when converting BLASTN mRNA alignment XML into segmented interval reports and strand-overlap summaries in EDirect pipelines.

Use when converting GFF or GFF3 feature annotations into structured XML for downstream EDirect-style processing.

Use when a GFF file needs bcftools/csq-compatible gene and transcript attributes before consequence annotation.

Use when converting GenBank flatfiles into XML for downstream EDirect or XML-based sequence annotation workflows.

Use when converting GenBank format files to table format as part of the Entrez Direct toolkit from bioconda.

Use when working with GenBank format files and need to create reference indexers for sequence data retrieval or processing within the Entrez Direct toolkit.

Use when converting GenBank format (.gbf) files to FASTA format (.fsa) as part of sequence data preprocessing

Use when converting FASTA sequence records into XML for downstream EDirect or XML-based sequence processing.

Use when annotating VCF files with flanking sequence information (INFO/FS tag) or masking regions/variants in flanking sequences.

Use when filling ancestral alleles into the INFO column of VCF files using ancestral alignment data from 1000 Genomes or similar sources.

Use when searching NCBI Entrez databases (pubmed, gene, protein, nuccore, snp, geoprofiles) with query strings and field qualifiers to retrieve record UIDs for downstream processing.

Use when printing canned sample NCBI XML, JSON, flatfile, or GFF documents for testing, parser development, or xtract query prototyping.

Use when filtering Entrez search results by date, organism, publication type, sequence features, or other database-specific criteria in bioinformatics pipelines.